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Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie

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Total 256 results found since Jan 2013.

Reversal of chemoresistance with small interference RNA (siRNA) in etoposide resistant acute myeloid leukemia cells (HL-60).
CONCLUSIONS: Our results indicate that product of the ABCB1 gene have effective role in resistance to etoposide in acute myeloid leukemia cells. PMID: 26463638 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 1, 2015 Category: Drugs & Pharmacology Authors: Kachalaki S, Baradaran B, Majidi J, Yousefi M, Shanehbandi D, Mohammadinejad S, Mansoori B Tags: Biomed Pharmacother Source Type: research

Down-regulation of miR-186 contributes to podocytes apoptosis in membranous nephropathy.
CONCLUSIONS: We revealed that TLR4 is involved in the regulation of miR-186 expression, and the anti-apoptotic effect of miR-186 on podocytes is correlated with P2×7 regulation. PMID: 26382839 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 14, 2015 Category: Drugs & Pharmacology Authors: Sha WG, Shen L, Zhou L, Xu DY, Lu GY Tags: Biomed Pharmacother Source Type: research

Induction of cytosine arabinoside-resistant human myeloid leukemia cell death through autophagy regulation by hydroxychloroquine.
Abstract We investigated the effects of the autophagy inhibitor hydroxychloroquine (HCQ) on cell death of cytosine arabinoside (Ara-C)-resistant human acute myeloid leukemia (AML) cells. Ara-C-sensitive (U937, AML-2) and Ara-C-resistant (U937/AR, AML-2/AR) human AML cell lines were used to evaluate HCQ-regulated cytotoxicity, autophagy, and apoptosis as well as effects on cell death-related signaling pathways. We found that HCQ-induced dose- and time-dependent cell death in Ara-C-resistant cells compared to Ara-C-sensitive cell lines. The extent of cell death and features of HCQ-induced autophagic markers includin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 1, 2015 Category: Drugs & Pharmacology Authors: Kim Y, Eom JI, Jeung HK, Jang JE, Kim JS, Cheong JW, Kim YS, Min YH Tags: Biomed Pharmacother Source Type: research

The STAT3-regulated long non-coding RNA Lethe promote the HCV replication.
CONCLUSIONS: Based on our findings from Lethe knockdown, we have identified that Lethe, which was upregulated by activated STAT3, may promoting the replication of HCV through a negative regulatory mechanism of type I IFN response. PMID: 26054691 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2015 Category: Drugs & Pharmacology Authors: Xiong Y, Yuan J, Zhang C, Zhu Y, Kuang X, Lan L, Wang X Tags: Biomed Pharmacother Source Type: research

miR-892a regulated PPP2R2A expression and promoted cell proliferation of human colorectal cancer cells.
Abstract Colorectal cancer (CRC) is one of the most common malignancy cancers in the world. Aberrant microRNA expression is involved in human diseases including cancer. In the present study, we investigated the miR-892a's role in CRC cell proliferation. We found that miR-892a was frequently upregulated in human colorectal cancer tissues and cell lines compared with the matched tumor adjacent tissues and normal colonic cell line FHC. Overexpression of miR-892a promoted cell proliferation and colony formation of CRC. Bioinformatics analysis further revealed PPP2R2A was identified as a potential miR-892a. Overexpress...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2015 Category: Drugs & Pharmacology Authors: Liang WL, Cao J, Xu B, Yang P, Shen F, Sun Z, Li WL, Wang Q, Liu F Tags: Biomed Pharmacother Source Type: research

miR-20a mediates temozolomide-resistance in glioblastoma cells via negatively regulating LRIG1 expression.
Abstract AIMS: Resistance to temozolomide (TMZ) is a major obstacle in the treatment of glioblastoma multiforme (GBM). MiRNAs is considered as an important modulator of drug resistance in many cancers. Here, we aimed to elucidate the relationship between miR-20a, its predicted target genes leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) and TMZ resistance in GBM. MAIN METHODS: Real-time PCR or western blot was used to measure the levels of miR-20a and LRIG1. The cell viability was obtained to investigate the sensitivity of U251 cells and TMZ-resistant U251 (U251/TMZ) cells to TMZ. MiR-20a inhib...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 1, 2015 Category: Drugs & Pharmacology Authors: Wei J, Qi X, Zhan Q, Zhou D, Yan Q, Wang Y, Mo L, Wan Y, Xie D, Xie J, Yang S Tags: Biomed Pharmacother Source Type: research

miR-25 promotes glioma cell proliferation by targeting CDKN1C.
Abstract MicroRNAs (miRNA) have oncogenic or tumor-suppressive roles in the development and growth of human glioma. Glioma development is also associated with alteration in the activities and expression of cell cycle regulators, and miRNAs are emerging as important regulators of cell cycle progression. Here, we show that miR-25 is overexpressed in 91% of examined human glioma tissues and 4 out of 6 human glioma cell lines. MiR-25 increases cell proliferation in two independent glioma cell lines. Ectopic expression of miR-25 was found to reduce CDKN1C protein levels by directly targeting its 3'-untranslated region ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 1, 2015 Category: Drugs & Pharmacology Authors: Zhang J, Gong X, Tian K, Chen D, Sun J, Wang G, Guo M Tags: Biomed Pharmacother Source Type: research

Epigallocatechin-3-gallate attenuates transforming growth factor-β1 induced epithelial-mesenchymal transition via Nrf2 regulation in renal tubular epithelial cells.
This study aims to investigate whether EGCG prevents TGF-β1 induced EMT and whether this effect acts via the Nrf2-mediated suppression of TGF-β1 signaling. MTT was used for cytotoxicity of EGCG examination and Western blotting and immunofluorescence were used for protein expression analysis. Results showed that EGCG prevented TGF-β1 mediated EMT and Smad 2 and Smad 3 phosphorylation in a dose dependent manner in NRK-52E cells. In addition, EGCG increased Nrf2 nuclear accumulation. Overexpression of Nrf2 blocked the phosphorylation of Smad 2 and Smad 3 mediated by TGF-β1 and decreased protein expression of plasminogen a...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 1, 2015 Category: Drugs & Pharmacology Authors: Wang Y, Liu N, Su X, Zhou G, Sun G, Du F, Bian X, Wang B Tags: Biomed Pharmacother Source Type: research

Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma.
In conclusion, our results demonstrate that 12k has an inhibitory effect on growth of A549 cell by inducing cell cycle arrest and apoptosis. PMID: 25776505 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 1, 2015 Category: Drugs & Pharmacology Authors: Dai B, Wang W, Liu R, Wang H, Zhang Y Tags: Biomed Pharmacother Source Type: research

Smoothened activates breast cancer stem-like cell and promotes tumorigenesis and metastasis of breast cancer.
Abstract Smoothened (Smo) is a G protein-coupled receptor protein encoded by the Smo gene of the hedgehog signalling pathway, which is thought to play an important role in maintaining organ patterning, cell differentiation and self-renewal. The possible role of Smo in the process of tumorigenesis and metastasis of breast cancer still remains unclear. The present experiments were to investigate the effect of Smo on activating breast cancer stem-like CD44(+)CD24(-) cells and the tumorigenesis and metastasis of breast cancer. By injected CD44(+)CD24(-) cells (1×10(4)) into the cleared fat pad of NOD/SCID mice, it wa...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 3, 2014 Category: Drugs & Pharmacology Authors: Wang L, Duan W, Kang L, Mao J, Yu X, Fan S, Li L, Tao Y Tags: Biomed Pharmacother Source Type: research

Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma.
This study aims to find the key LncRNA associated with lung adenocarcinoma and to evaluate its biological role and clinical significance in tumor progression. Microarray analysis of 32,756 LncRNA was performed to screen the significantly different LncRNA between human lung adenocarcinoma tissues and adjacent non-cancerous lung tissues, which was named as LncRNA ZXF1. Expression of LncRNA ZXF1 was analyzed in 62 lung adenocarcinoma tissues and adjacent non-cancerous lung tissues by quantitative reverse-transcription PCR (qRT-PCR). Correlations between LncRNA ZXF1 expression and the clinicopathological features and prognosis...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 19, 2014 Category: Drugs & Pharmacology Authors: Zhang L, Zhou XF, Pan GF, Zhao JP Tags: Biomed Pharmacother Source Type: research

Vimentin silencing effect on invasive and migration characteristics of doxorubicin resistant MCF-7 cells.
In this study, MCF-7 cell line which is a model for human mammary carcinoma, and a doxorubicin resistant subline (MCF-7/Dox) were used. The resistant subline was previously obtained by stepwise selection in our laboratory. In the resistant cells, high levels of vimentin expression were observed. The main purpose of this study was to investigate changes in invasive and migration characteristics of MCF-7/Dox cell line, after transient silencing of vimentin gene by specific siRNA. PMID: 24612689 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 13, 2014 Category: Drugs & Pharmacology Authors: Tezcan O, Gündüz U Tags: Biomed Pharmacother Source Type: research

Down-regulation of ANXA7 decreases metastatic potential of human hepatocellular carcinoma cells in vitro.
We report for the first time the influence of ANXA7 gene on human hepatocellular carcinoma cells (HCC). We down-regulated ANXA7 in human HCC cell line (HepG2) using siRNA method. By Western Blot analysis, we confirmed about 70% down-regulation of the gene in the shRNA-ANXA7 transfected cells (shRNA-ANXA7-HepG2) compared to the non-specific sequence shRNA transfected cells (control-shRNA-HepG2) and the un-manipulated-HepG2 cells. We used CCK-8 cell proliferation kit and observed about 65% reduction in the shRNA-ANXA7-HepG2 cells where the two controls exhibited comparable cell proliferation rates. Also, by using PI staining...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2013 Category: Drugs & Pharmacology Authors: Ibrahim MM, Sun MZ, Huang Y, Jun M, Jin Y, Yue D, Jiasheng W, Zhang J, Qazi AS, Sagoe K, Tang J Tags: Biomed Pharmacother Source Type: research

Decitabine, a DNA methyltransferases inhibitor, induces cell cycle arrest at G2/M phase through p53-independent pathway in human cancer cells.
Abstract Decitabine (5-aza-2'-deoxycytidine), an inhibitor of DNA methyltransferases, has a wide range of anti-metabolic and anti-cancer activities. Decitabine also induces cell cycle arrest at G2/M phase and apoptosis in human cancer cells. However, the cellular and molecular mechanisms of this cell cycle arrest are poorly understood. In the present study, we investigated the roles of the tumor suppressor p53 and the cyclin-dependent kinase (Cdk) inhibitor p21 following decitabine-induced G2/M arrest in human cancer cells. DNA flow cytometric analyses indicated that decitabine induced a G2/M arrest in AGS gastric...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2013 Category: Drugs & Pharmacology Authors: Shin DY, Sung Kang H, Kim GY, Kim WJ, Yoo YH, Choi YH Tags: Biomed Pharmacother Source Type: research

Synergistic induction of TRAIL-mediated apoptosis by anisomycin in human hepatoma cells via the BH3-only protein Bid and c-Jun/AP-1 signaling pathway.
Abstract Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF super-family, and it has been shown that many human cancer cell lines are refractory to TRAIL-induced cell death. However, the molecular mechanisms underlying resistance are unclear. In the present study, we show that TRAIL-resistance is reversed in human hepatoma cells by anisomycin, which is known to inhibit protein synthesis and induce ribotoxic stress. Synergistic induction of apoptosis in cells treated with anisomycin plus TRAIL was associated with activation of caspases and cleavage of Bid, a pro-apoptotic B...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 1, 2013 Category: Drugs & Pharmacology Authors: Jin CY, Park C, Hong SH, Han MH, Jeong JW, Xu H, Liu H, Kim GY, Kim WJ, Yoo YH, Choi YH Tags: Biomed Pharmacother Source Type: research