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Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer.
In this study, we chose hsa_circ_0000064 as a targeted circRNA to investigate its clinical significances in lung cancer patients. The result indicated that hsa_circ_0000064 was up-regulated in lung cancer tissues and lung cancer cell lines (A549 and H1229). Moreover, its aberrant expression was correlated with several clinical characteristics, including T stage, lymphatic metastasis, and TNM stage. Fluorescence in situ hybridization detected that hsa_circ_0000064 was mostly located in the cytoplasm in A549 and H1229 cells. In addition, knockdown of hsa_circ_0000064 with siRNA dramatically attenuated the proliferation, bloc...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 6, 2017 Category: Drugs & Pharmacology Authors: Luo YH, Zhu XZ, Huang KW, Zhang Q, Fan YX, Yan PW, Wen J Tags: Biomed Pharmacother Source Type: research

The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells.
Abstract The purpose of this study was to explore the role by which the DNA-dependent protein kinase complex catalytic subunit (DNA-PKcs) influences osteosarcoma MG-63 cell apoptosis, proliferation, migration and invasion. Osteosarcoma tissues and adjacent normal tissues were obtained from 57 osteosarcoma patients. Human osteosarcoma MG-63 cells were assigned into designated groups including the blank, siRNA-negative control (NC) and siRNA-DNA-PKcs groups. RT-qPCR and Western blotting methods were employed to evaluate the mRNA and protein expressions of DNA-PKcs. A cell counting kit-8 (CCK-8) assay was performed t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 1, 2017 Category: Drugs & Pharmacology Authors: Jin PY, Lu HJ, Tang Y, Fan SH, Zhang ZF, Wang Y, Li XN, Wu DM, Lu J, Zheng YL Tags: Biomed Pharmacother Source Type: research

Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling.
In conclusion, our results highlight the importance of CDKN3 in PC and provide new insights into diagnostics and therapeutics of the PC. PMID: 29196103 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 28, 2017 Category: Drugs & Pharmacology Authors: Yu C, Cao H, He X, Sun P, Feng Y, Chen L, Gong H Tags: Biomed Pharmacother Source Type: research

Activation of Epac alleviates inflammation and vascular leakage in LPS-induced acute murine lung injury.
In this study, we treated in vitro and in vivo models with the Epac activator 8CPT to determine the effect and related mechanisms of Epac. The in vitro results indicate that 8CPT inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) release from mouse macrophages (MH-S), whereas the protein kinase A (PKA) activator 6BnZ has no effect. Furthermore, Epac over-expression can significantly suppress TNF-α release from LPS induced MH-S cell, while Epac siRNA can slightly increase TNF-α release. Moreover, 8CPT reduces LPS-induced microvascular permeability in human pulmonary microvascular endothelial cells...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 23, 2017 Category: Drugs & Pharmacology Authors: Wang X, Song S, Hu Z, Zhang Z, Li Y, Yan C, Li Z, Tang H Tags: Biomed Pharmacother Source Type: research

Increase in renal erythropoietin receptors in diabetic rats is mainly mediated by hyperglycemia associated with the STAT3/GATA-1 signaling pathway.
Abstract Erythropoietin (EPO) produces cytoprotection in many tissues by activating the EPO receptor (EPOR); these effects include anti-oxidative stress and the inhibition of apoptosis in renal tubular cells. Moreover, EPO is clinically used in diabetic patients who suffer from chronic renal disease. However, the effect of hyperglycemia on renal EPOR expression remains unknown. Therefore, we determined the changes in renal EPOR expression in diabetic rats and investigated the role of potential factors using cultured cells. Streptozotocin-induced hyperglycemic rats (STZ rats) treated with insulin or phloridzin to c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 22, 2017 Category: Drugs & Pharmacology Authors: Kuo SC, Li Y, Cheng KC, Niu CS, Cheng JT, Niu HS Tags: Biomed Pharmacother Source Type: research

KIF3A knockdown sensitizes bronchial epithelia to apoptosis and aggravates airway inflammation in asthma.
CONCLUSION: KIF3A plays an important role in epithelium apoptosis and bronchial inflammation in asthma, and may be a potential target for asthma treatment. PMID: 29156524 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 15, 2017 Category: Drugs & Pharmacology Authors: Geng G, Du Y, Dai J, Tian D, Xia Y, Fu Z Tags: Biomed Pharmacother Source Type: research

Cancer-associated fibroblasts confer cisplatin resistance of tongue cancer via autophagy activation.
Abstract Cancer-associated fibroblasts (CAFs) play important roles in carcinogenesis and progression of tongue squamous cell carcinoma (TSCC). However, effect of CAFs on chemotherapy resistance of TSCC remains largely obscure. Here, we cultured the matched primary CAFs and normal fibroblasts (NFs) pairs and detected their roles in cisplatin sensitivity of TSCC, as well as autophagy-related protein LC3 and Beclin1 expressions. During exposure to cisplatin, TSCC with CAFs group exhibited significantly increased cell viability and IC50, but reduced apoptosis than that with NFs group. Meanwhile, cisplatin increased t...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 14, 2017 Category: Drugs & Pharmacology Authors: Liao JK, Zhou B, Zhuang XM, Zhuang PL, Zhang DM, Chen WL Tags: Biomed Pharmacother Source Type: research

Up-regulation of miR-299 suppressed the invasion and migration of HTR-8/SVneo trophoblast cells partly via targeting HDAC2 in pre-eclampsia.
Abstract Pre-eclampsia (PE), a pregnancy-associated disorder, is a major contributor to maternal mortality and morbidity worldwide. Recently, microRNAs (miRNAs) were found to be associated with the pathogenesis of PE. The present study investigated the function of miR-299 in HTR-8/SVneo trophoblast cells and explored its underlying mechanism in the pathogenesis of PE. The miR-299 and histone deacetylase 2 (HDAC2) mRNA expression levels were determined by quantitative real-time PCR. Transwell invasion and wound healing assays were used to measure cell invasive and migratory ability. Luciferase reporter assay was pe...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 13, 2017 Category: Drugs & Pharmacology Authors: Gao Y, She R, Wang Q, Li Y, Zhang H Tags: Biomed Pharmacother Source Type: research

Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway.
CONCLUSIONS: TMAO promotes the atherosclerosis in vivo and in vitro.CD36/MAPK/JNK pathway may play a crucial role in TMAO-induced formation of foam cells. PMID: 29136772 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 7, 2017 Category: Drugs & Pharmacology Authors: Geng J, Yang C, Wang B, Zhang X, Hu T, Gu Y, Li J Tags: Biomed Pharmacother Source Type: research

Hispidulin prevents sevoflurane- Induced memory dysfunction in aged rats.
CONCLUSION: As our study provides in vitro and in vivo evidence that hispidulin can offer protection against sevoflurane-induced neurological dysfunction, hispidulin has the potential to be a neuroprotective agent that can improve the cognitive and memory function of elderly patients undergoing anesthesia. PMID: 29091891 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 27, 2017 Category: Drugs & Pharmacology Authors: Huang L, Huang K, Ning H Tags: Biomed Pharmacother Source Type: research

RUNX3 inhibits the proliferation and metastasis of gastric cancer through regulating miR-182/HOXA9.
CONCLUSIONS: RUNX3 could impede the ability of GC cells proliferation, migration and invasion by modulating miR-182/HOXA9 pathway. PMID: 29054094 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 17, 2017 Category: Drugs & Pharmacology Authors: Yu J, Tian X, Chang J, Liu P, Zhang R Tags: Biomed Pharmacother Source Type: research

An analysis of suppressing migratory effect on human urinary bladder cancer cell line by silencing of snail-1.
CONCLUSION: These results propose that snail-1 plays a major role in the progression and migration of urinary bladder cancer, and can be a potential therapeutic target for target therapy of invasive urinary bladder cancer. PMID: 29032338 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 12, 2017 Category: Drugs & Pharmacology Authors: Salehi S, Mansoori B, Mohammadi A, Davoudian S, Musavi Shenas SMH, Shajari N, Majidi J, Baradaran B Tags: Biomed Pharmacother Source Type: research

Regulation of HOXA11-AS/miR-214-3p/EZH2 axis on the growth, migration and invasion of glioma cells.
CONCLUSIONS: We demonstrated that HOXA11-AS acted as an oncogenic lncRNA that promoted cell growth and metastasis of glioma through regulating miR-214-3p/EZH2 axis. These results suggested HOXA11-AS may serve as an efficient marker and a potential therapeutic target for glioma. PMID: 28946213 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 20, 2017 Category: Drugs & Pharmacology Authors: Xu C, He T, Li Z, Liu H, Ding B Tags: Biomed Pharmacother Source Type: research

MiR-337-3p promotes chondrocytes proliferation and inhibits apoptosis by regulating PTEN/AKT axis in osteoarthritis.
CONCLUSION: MiR-337-3p regulated OA chondrocytes proliferation through PTEN/AKT axis and thus involved in OA. PMID: 28931211 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2017 Category: Drugs & Pharmacology Authors: Huang Z, Zhang N, Ma W, Dai X, Liu J Tags: Biomed Pharmacother Source Type: research

IL-1 β-induced NF-κB activation down-regulates miR-506 expression to promotes osteosarcoma cell growth through JAG1.
IL-1β-induced NF-κB activation down-regulates miR-506 expression to promotes osteosarcoma cell growth through JAG1. Biomed Pharmacother. 2017 Sep 15;95:1147-1155 Authors: Hu M, Yuan X, Liu Y, Tang S, Miao J, Zhou Q, Chen S Abstract Nowadays, the role of miRNA in tumorigenesis has been largely reported. It was found that miR-506 might be associated with tumorigenesis of various cancers. The present study was aimed to investigate the character of miR-506 and some related factors in human osteosarcoma (OS) carcinogenesis. The expression level of miR-506 was downregulated in OS compared with the normal ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2017 Category: Drugs & Pharmacology Authors: Hu M, Yuan X, Liu Y, Tang S, Miao J, Zhou Q, Chen S Tags: Biomed Pharmacother Source Type: research

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