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Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie
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Total 256 results found since Jan 2013.
Induction of autophagy via the PI3K/Akt/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice
Biomed Pharmacother. 2022 Nov 13;157:114005. doi: 10.1016/j.biopha.2022.114005. Online ahead of print.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is the most common among lipid metabolism disorders. Autophagy plays an important role in lipid metabolism in NAFLD. Pueraria flavonoids, the main active ingredients of Pueraria lobata, exert antioxidant and anti-inflammatory effects. Herein, we report the potential lipid-lowering and anti-inflammatory effects of Pueraria flavonoids on NAFLD induced by a high-fat diet. In vivo and in vitro experiments showed that Pueraria flavonoids reduced intracellular lipid deposition by...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 16, 2022 Category: Drugs & Pharmacology Authors: Chunbin Sun Jin Zhang Jiong Hou Menglin Hui Hualong Qi Tong Lei Xiaoshuang Zhang Luxi Zhao Hongwu Du Source Type: research
SOX2 function in cancers: Association with growth, invasion, stemness and therapy response
Biomed Pharmacother. 2022 Oct 19;156:113860. doi: 10.1016/j.biopha.2022.113860. Online ahead of print.ABSTRACTCancer is a leading cause of death worldwide and around 10 million deaths in 2020 were related to cancer. There are a number of therapeutic modalities for cancer such as chemotherapy, radiotherapy and surgery. However, tumor cells have capacity of developing resistance to chemotherapy and radiotherapy. Genetic mutations participate in development and progression of cancer. The current review focuses on the role of SOX2 transcription factor in cancer. SOX2 has capacity of increasing growth and metastasis of cancer c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 22, 2022 Category: Drugs & Pharmacology Authors: Sepideh Mirzaei Mahshid Deldar Abad Paskeh Maliheh Entezari Seyed Reza Mirmazloomi Aria Hassanpoor Maryam Aboutalebi Shamin Rezaei Elahe Sadat Hejazi Amirabbas Kakavand Hajar Heidari Shokooh Salimimoghadam Afshin Taheriazam Mehrdad Hashemi Saeed Samarghan Source Type: research
Effects of Sedi Herba (Sedum sarmentosum) on attenuating cholestasis by the activation of the farnesoid x receptor (FXR)-mediated signaling
This study aimed to clarify the anti-cholestatic efficacy and the mechanism of S. sarmentosum ethyl acetate extract (SDEAE), as well as to screen the potential compounds with FXR activation. SDEAE effectively ameliorated ANIT-induced cholestasis in rats, as evidenced by the ameliorative histopathology of the liver and the significant decrease in biochemical markers (ALT, AST, ALP, GGT, TBIL, DBIL and TBA). The analysis of bile acid profile by LC-MS indicated that SDEAE decreased the toxic bile acid levels (TCA, TMCA and CA). Western blotting indicated that SDEAE activated FXR-associated pathway, thereby upregulating FXR, S...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 22, 2022 Category: Drugs & Pharmacology Authors: Zhenxiu Liu Die Liu Mingyun Chen Wei Zong Xiaoran Zhou Fancheng Meng Yunbin Jiang Min Chen Zhihua Liao Guowei Wang Source Type: research
SOX2 function in cancers: Association with growth, invasion, stemness and therapy response
Biomed Pharmacother. 2022 Oct 20;156:113860. doi: 10.1016/j.biopha.2022.113860. Online ahead of print.ABSTRACTCancer is a leading cause of death worldwide and around 10 million deaths in 2020 were related to cancer. There are a number of therapeutic modalities for cancer such as chemotherapy, radiotherapy and surgery. However, tumor cells have capacity of developing resistance to chemotherapy and radiotherapy. Genetic mutations participate in development and progression of cancer. The current review focuses on the role of SOX2 transcription factor in cancer. SOX2 has capacity of increasing growth and metastasis of cancer c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 22, 2022 Category: Drugs & Pharmacology Authors: Sepideh Mirzaei Mahshid Deldar Abad Paskeh Maliheh Entezari Seyed Reza Mirmazloomi Aria Hassanpoor Maryam Aboutalebi Shamin Rezaei Elahe Sadat Hejazi Amirabbas Kakavand Hajar Heidari Shokooh Salimimoghadam Afshin Taheriazam Mehrdad Hashemi Saeed Samarghan Source Type: research
Effects of Sedi Herba (Sedum sarmentosum) on attenuating cholestasis by the activation of the farnesoid x receptor (FXR)-mediated signaling
This study aimed to clarify the anti-cholestatic efficacy and the mechanism of S. sarmentosum ethyl acetate extract (SDEAE), as well as to screen the potential compounds with FXR activation. SDEAE effectively ameliorated ANIT-induced cholestasis in rats, as evidenced by the ameliorative histopathology of the liver and the significant decrease in biochemical markers (ALT, AST, ALP, GGT, TBIL, DBIL and TBA). The analysis of bile acid profile by LC-MS indicated that SDEAE decreased the toxic bile acid levels (TCA, TMCA and CA). Western blotting indicated that SDEAE activated FXR-associated pathway, thereby upregulating FXR, S...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - October 22, 2022 Category: Drugs & Pharmacology Authors: Zhenxiu Liu Die Liu Mingyun Chen Wei Zong Xiaoran Zhou Fancheng Meng Yunbin Jiang Min Chen Zhihua Liao Guowei Wang Source Type: research
A-kinase anchoring protein 5-ancored calcineurin regulates the remodeling of H9c2 cardiomyocytes exposed to hypoxia and reoxygenation
CONCLUSIONS: AKAP5 downregulation aggravated the remodeling of cardiomyocytes after H/R. AKAP5 may anchor CaN to form a complex, which in turn activates NFATc3 dephosphorylation and expression of hypertrophy-related proteins.PMID:36115111 | DOI:10.1016/j.biopha.2022.113689
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 17, 2022 Category: Drugs & Pharmacology Authors: Feng Zhu Chi Yuan Xu Zhang Zhi Wang Qiushu Wang Hegui Wang Source Type: research
Specific activation of hypoxia-inducible factor-2 α by propionate metabolism via a β-oxidation-like pathway stimulates MUC2 production in intestinal goblet cells
In this study, we investigated the mechanism of MUC2 expression by propionate, an SCFA, in intestinal goblet cells. The real time oxygen consumption rate (OCR) and ATPase activity were measured to investigate the induction of hypoxia by propionate. Using 2-dimensional electrophoresis (2-DE), microarray analysis, and siRNA-induced gene silencing, we found that propionate is metabolized via a β-oxidation-like pathway instead of the vitamin B12-dependent carboxylation pathway (also known as the methylmalonyl pathway). We verified the results by analyzing several intermediates in the pathway using LC-MS and GC-MS. Propionate ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 12, 2022 Category: Drugs & Pharmacology Authors: Seongho Ma Jiah Yeom Young-Hee Lim Source Type: research
Galanin N-terminal fragment (1-15) reduces alcohol seeking and alcohol relapse in rats: Involvement of mesocorticolimbic system
Biomed Pharmacother. 2022 Sep;153:113508. doi: 10.1016/j.biopha.2022.113508. Epub 2022 Aug 4.ABSTRACTAlcohol Use Disorder (AUD) is among the most prevalent mental illnesses, and due to the low efficacy of the current medication, it is essential to find new biological targets that could modulate alcohol consumption. Since Galanin (1-15) [GAL(1-15)] produces a loss of motivational behaviour by an artificial reinforcer and decreases the preference an alcohol consumption in a voluntary alcohol intake, we have studied the role of GAL(1-15) in alcohol-seeking behaviour and the involvement of the corticomesolimbic system as well ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 9, 2022 Category: Drugs & Pharmacology Authors: Noelia Cantero-Garc ía Antonio Flores-Burgess Juan Pedro Pineda-G ómez Laura Orio Antonia Serrano Zaida D íaz-Cabiale Carmelo Mill ón Source Type: research
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3 β/Nrf2 axis
In conclusion, Dex protects hearts against MIRI-induced ferroptosis via activation of Nrf2 through AMPK/GSK-3β signaling pathway.PMID:35988428 | DOI:10.1016/j.biopha.2022.113572
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 21, 2022 Category: Drugs & Pharmacology Authors: Zhuoran Wang Mengran Yao Leyu Jiang Lingyan Wang Yuqiao Yang Quan Wang Xi Qian Yu Zhao Jinqiao Qian Source Type: research
PPAR γ activation inhibits PDGF-induced pulmonary artery smooth muscle cell proliferation and migration by modulating TERT
This study aims to explore whether TERT mediates the proliferation and migration of PASMCs and the underlying molecular mechanism. Primary PASMCs from Sprague-Dawley (SD) rats were used in this experiment. Cell proliferation and migration were evaluated by Cell Counting Kit-8, EdU incorporation assay and transwell assay, respectively. Telomerase activity was assessed with a rat TE ELISA kit. Small interfering RNA (siRNA) transfection was conducted to silence c-MYC expression. The protein levels of p-Akt, c-MYC, PPARγ and TERT were determined through western blotting. Our work demonstrates that PDGF upregulated TERT expres...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 11, 2022 Category: Drugs & Pharmacology Authors: Qianqian Zhang Wei Feng Qingting Wang Jian Wang Limin Chai Yuqian Chen Yan Wang Jin Liu Manxiang Li Xinming Xie Source Type: research
Interleukin-6 neutralizing antibody attenuates the hypersecretion of airway mucus via inducing the nuclear translocation of Nrf2 in chronic obstructive pulmonary disease
Biomed Pharmacother. 2022 Jun 7;152:113244. doi: 10.1016/j.biopha.2022.113244. Online ahead of print.ABSTRACTAirway mucus hypersecretion is a vital pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients in which airflow limitation result, and it is key to strategizing in the management of COPD. To investigate the mechanisms underlying the action of interleukin-6 neutralizing antibody (IL-6 Ab) in attenuating airway mucus hypersecretion in COPD, human and mouse primary bronchial epithelial cells from COPD patients and mice were isolated, human organoid model of trachea was established and all trea...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 10, 2022 Category: Drugs & Pharmacology Authors: Yuan-Yuan Wei Da-Wei Zhang Jing-Jing Ye Qing-Xia Lan Shuang Ji Li Sun Fang Li Guang-He Fei Source Type: research
Molecular mechanism of the uptake and toxicity of EGF-LipoAgNPs in EGFR-overexpressing cancer cells
Biomed Pharmacother. 2022 Jun;150:113085. doi: 10.1016/j.biopha.2022.113085. Epub 2022 May 10.ABSTRACTThe surface of silver nanoparticles (AgNPs) is characterized by high reactivity resulting in prooxidative and cytotoxic properties. These effects are observed both in normal and in cancer cells, which overexpress the Epidermal Growth Factor Receptor (EGFR). In our previous paper, we have demonstrated that, with the use of liposomes labeled with the Epidermal Growth Factor (EGF), it is possible to direct the toxic effect of AgNPs in EGFR-overexpressing cells. Unfortunately, the mechanism of uptake and toxicity induction by ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 5, 2022 Category: Drugs & Pharmacology Authors: Bartosz Sk óra Konrad A Szychowski Source Type: research
