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Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie
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Total 256 results found since Jan 2013.
Desmoglein 3 gene mediates epidermal growth factor/epidermal growth factor receptor signaling pathway involved in inflammatory response and immune function of anaphylactic rhinitis.
CONCLUSION: Silencing DSG3 gene can inhibit the activation of EGF signaling pathway, alleviate the inflammation of AR nasal mucosa, and enhance red blood cells immune adherence function.
PMID: 31382129 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 1, 2019 Category: Drugs & Pharmacology Authors: Ri H, Peiyan Z, Jianqi W, Yunteng Z, Gang L, Baoqing S Tags: Biomed Pharmacother Source Type: research
Astragalus polysaccharide ameliorates lipopolysaccharide-induced cell injury in ATDC5 cells via miR-92a/KLF4 mediation.
CONCLUSIONS: The present study reveals that APS protects ATDC5 cells against LPS induced-injury by regulation of miR-92a/KLF4 axis and suppressing NF-κB and p38MAPK signal pathways.
PMID: 31302422 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 10, 2019 Category: Drugs & Pharmacology Authors: Fan L, Li M, Cao FY, Zeng ZW, Li XB, Ma C, Ru JT, Wu XJ Tags: Biomed Pharmacother Source Type: research
The oncogenic role of CB2 in the progression of non-small-cell lung cancer.
CONCLUSION: Our data suggested that targeting CB2 may inhibit the growth and survival of NSCLC cells, which the Akt/mTOR/P70S6K pathway may be involved in. These results confer the pro-oncogenic role of CB2 in the progression of NSCLC, thus improving our understanding of CB2 in tumor progression.
PMID: 31176172 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 4, 2019 Category: Drugs & Pharmacology Authors: Xu S, Ma H, Bo Y, Shao M Tags: Biomed Pharmacother Source Type: research
Magnesium isoglycyrrhizinate ameliorates radiation-induced pulmonary fibrosis by inhibiting fibroblast differentiation via the p38MAPK/Akt/Nox4 pathway.
Abstract
Radiation-induced pulmonary fibrosis (RIPF) is a severe complication in patients treated with thoracic irradiation. Until now, there are no effective therapeutic drugs for RIPF. In the present study, we attempted to evaluate the effect of Magnesium isoglycyrrhizinate (MgIG) on RIPF, and to further explore the underlying mechanisms. We found that MgIG treatment markedly improved radiation-induced lung pathological changes, reduced collagen deposition, and decreased the transforming growth factor beta1 (TGF-β1) elevation induced by irradiation. In addition, MgIG treatment significantly relieved oxidative d...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 6, 2019 Category: Drugs & Pharmacology Authors: Yang Q, Zhang P, Liu T, Zhang X, Pan X, Cen Y, Liu Y, Zhang H, Chen X Tags: Biomed Pharmacother Source Type: research
Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling.
Abstract
Hepatocellular carcinoma (HCC) results in large amounts of deaths each year worldwide. To develop more effective treatments for HCC, it is very necessary to define the molecular mechanisms in hepatocarcinogenesis. Mixed lineage kinase (MLK)-4 is a member of the MLK family of mitogen-activated protein kinase kinase kinases, and modulates different cellular responses. However, its role in the meditation of HCC progression remains unclear. In the study, we found that MLK4 was over-expressed in tumor samples of HCC patients. High MLK4 expression was significantly associated with shorter overall survival in HC...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 5, 2019 Category: Drugs & Pharmacology Authors: Li Y, Zuo H, Wang H, Hu A Tags: Biomed Pharmacother Source Type: research
Involvement of miR-665 in protection effect of dexmedetomidine against Oxidative Stress Injury in myocardial cells via CB2 and CK1.
CONCLUSIONS: Dex precondition confers hearts protective effect against I/R injury by down-regulating expression of miR-665 and up-regulating expression of AK1 and Cnr2.
PMID: 31026731 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 22, 2019 Category: Drugs & Pharmacology Authors: Yu J, Yang W, Wang W, Wang Z, Pu Y, Chen H, Wang F, Qian J Tags: Biomed Pharmacother Source Type: research
Anti-tumor effect of LATS2 on liver cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/ β-catenin pathway.
Anti-tumor effect of LATS2 on liver cancer death: Role of DRP1-mediated mitochondrial division and the Wnt/β-catenin pathway.
Biomed Pharmacother. 2019 Apr 10;114:108825
Authors: Zhang L, Li S, Wang R, Chen C, Ma W, Cai H
Abstract
Large tumor suppressor 2 (LATS2), an important mediator of the cell apoptotic response pathway, has been linked to the progression of several cancers. Here, we described the molecular feature of LATS2 as a novel antitumor factor in liver cancer cells in vitro. Western blotting was used to detect the expression of LATS2 and its downstream factors. ELISA, immunofluorescence, ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 9, 2019 Category: Drugs & Pharmacology Authors: Zhang L, Li S, Wang R, Chen C, Ma W, Cai H Tags: Biomed Pharmacother Source Type: research
Yap-Hippo promotes A549 lung cancer cell death via modulating MIEF1-related mitochondrial stress and activating JNK pathway.
Abstract
Although the role of Yes-associated protein (Yap) has been described in the progression of lung cancer, the downstream effector of the Yap-Hippo pathway has not been identified. Accordingly, the aim of our study is to explore whether Yap modulates the activity of lung cancer by controlling mitochondrial elongation factor 1 (MIEF1)-related mitochondrial stress in a manner dependent on the JNK pathway. Cell viability was determined via MTT, LDH release and immunofluorescence assays. ATP production, the mitochondrial membrane potential, and caspase-9 activity were investigated to assess mitochondrial functio...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 11, 2019 Category: Drugs & Pharmacology Authors: Zhou J, Zhang S, Li Z, Chen Z, Xu Y, Ye W, He Z Tags: Biomed Pharmacother Source Type: research
MicroRNA-370 protects against myocardial ischemia/reperfusion injury in mice following sevoflurane anesthetic preconditioning through PLIN5-dependent PPAR signaling pathway.
This study aims to investigate the effects of microRNA (miR-370) targeting perilipin-5 (PLIN5) in mice following sevoflurane anesthetic preconditioning (SAP). A mouse model of left ventricular myocardial IRI was established, followed by the evaluation of myocardial infarction size and cardiac function to determine the effects of SAP. The underlying regulatory mechanisms of miR-370 were analyzed in concert with the treatment of miR-370 mimic, miR-370 inhibitor, or siRNA against PLIN5 in cardiomyocytes isolated from mice with IRI. Also, cardiomyocyte proliferation, cell cycle distribution and apoptosis were evaluated followi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 7, 2019 Category: Drugs & Pharmacology Authors: Zhao YB, Zhao J, Zhang LJ, Shan RG, Sun ZZ, Wang K, Chen JQ, Mu JX Tags: Biomed Pharmacother Source Type: research
SUMO protease SENP1 acts as a ceRNA for TGFBR2 and thus activates TGFBR2/Smad signaling responsible for LPS-induced sepsis.
This study aims to explore the roles and related mechanisms of SUMO protease SENP1 in sepsis. Here, RNA-sequencing assay showed that SENP1 was significantly increased in human umbilical vein endothelial cells (HUVECs) with LPS treatment. Gene set enrichment analysis (GSEA) of RNA-sequencing dataset revealed that a positive enrichment of inflammation signatures was observed in HUVECs with SENP1 3'UTR overexpression. Further functional annotation analysis revealed that SENP1 3'UTR overexpression was positively correlated with TGFBR2 signaling pathway. Mechanistically, TGFBR2 was identified as a ceRNA (competing endogenous RN...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 20, 2019 Category: Drugs & Pharmacology Authors: Zhang C, Li J, Qiu X, Chen Y, Zhang X Tags: Biomed Pharmacother Source Type: research
Lycium barbarum polysaccharide reduces hyperoxic acute lung injury in mice through Nrf2 pathway.
CONCLUSIONS: LBP improves hyperoxic ALI via Nrf2-dependent manner. The LBP-induced activation of Nrf2 is mediated, at least in part, by AMPK pathway.
PMID: 30611998 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 3, 2019 Category: Drugs & Pharmacology Authors: Zheng G, Ren H, Li H, Li X, Dong T, Xu S, Yan Y, Sun B, Bai J, Li Y Tags: Biomed Pharmacother Source Type: research
Kaempferol protects mice from d-GalN/LPS-induced acute liver failure by regulating the ER stress-Grp78-CHOP signaling pathway.
In conclusion, kaempferol inhibits hepatocyte apoptosis to protect mice from liver failure by regulating the ER stress-Grp78-CHOP signaling pathway. Therefore, kaempferol may be used to treat ALF.
PMID: 30594786 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - December 27, 2018 Category: Drugs & Pharmacology Authors: Wang H, Chen L, Zhang X, Xu L, Xie B, Shi H, Duan Z, Zhang H, Ren F Tags: Biomed Pharmacother Source Type: research
Baicalein stimulates fibroblast growth factor 21 expression by up-regulating retinoic acid receptor-related orphan receptor α in C2C12 myotubes.
Abstract
Retinoic acid receptor-related orphan receptor (ROR) α has been implicated in various physiological functions, including the immune system, inflammation, and circadian rhythms. In the present study, the synthetic RORα/γ agonist SR1078 stimulated the production and gene expression of fibroblast growth factor 21 (FGF21) in C2C12 myotubes. FGF21, a member of the FGF family, plays important roles in the regulation of peripheral glucose tolerance and lipid metabolism and improves metabolic health. The mRNA expression and secretion of FGF21 was significantly weaker in Rora-silenced cells than in cells transf...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 3, 2018 Category: Drugs & Pharmacology Authors: Hirai T, Nomura K, Ikai R, Nakashima KI, Inoue M Tags: Biomed Pharmacother Source Type: research
Farrerol attenuates β-amyloid-induced oxidative stress and inflammation through Nrf2/Keap1 pathway in a microglia cell line.
In conclusion, farrerol attenuated Aβ-induced oxidative stress and inflammation in BV-2 cells through enhancing the activation of Nrf2/Keap1 pathway. The findings indicated that farrerol could be considered as a therapeutic approach for the treatment of Alzheimer's disease (AD).
PMID: 30396067 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 2, 2018 Category: Drugs & Pharmacology Authors: Cui B, Zhang S, Wang Y, Guo Y Tags: Biomed Pharmacother Source Type: research
Role of high mobility group A1/nuclear factor-kappa B signaling in coronary microembolization-induced myocardial injury.
CONCLUSIONS: HMGA1/NF-κB signaling is involved in CME-induced myocardial inflammation. Inhibition of HMGA1/NF-κB signaling attenuated the CME-induced myocardial injury and improved cardiac function, suggesting a new potential target for the prevention and treatment of CME-induced myocardial injury.
PMID: 30021353 [PubMed - in process]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 21, 2018 Category: Drugs & Pharmacology Authors: Su Q, Lv X, Sun Y, Yang H, Ye Z, Li L Tags: Biomed Pharmacother Source Type: research
