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Total 42 results found since Jan 2013.

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and antioxidant response in mice.
This article is protected by copyright. All rights reserved. PMID: 27094017 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - April 19, 2016 Category: Physiology Authors: Merry TL, Ristow M Tags: J Physiol Source Type: research

Circulating “LncPPARδ” From Monocytes as a Novel Biomarker for Coronary Artery Diseases
Abstract: To investigate long noncoding RNA NONHSAT112178 (LncPPARδ) as a biomarker for coronary artery disease (CAD) in peripheral blood monocyte cells, RT-qPCR was performed to validate the microarray results, receiver operating characteristic curve was applied to study the potential of LncPPARδ as a biomarker. Diagnostic models from LncPPARδ alone or combination of risk factors were constructed by Fisher criteria. The expression of genes neighboring the LncPPARδ gene was examined with RT-qPCR in THP-1 cell line treated with LncPPARδ siRNA. Using a diagnostic model by Fisher criteria, the consideration of risk facto...
Source: Medicine - February 1, 2016 Category: Internal Medicine Tags: Research Article: Diagnostic Accuracy Study Source Type: research

P67
In this study, we have investigated microvesicles and miRNA from urine of healthy donors and PCa patients. To isolate miRNAs from urine and microparticles, novel methods for miRNA isolation were elaborated (Rus. patent application No 2014137763, priority date 17.09.2014). The study population included 14 patients with PCa (63–82years, T2-3NxMx1) and control group of 20 healthy volunteers with no previous history of prostate disease (48–73years). Urine was clarified by two serial centrifugations at 400g, 20°C, 20min and at 17000g, 20°C, 20min. Microparticles were precipitated from the resulting supernatant by high-spe...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

Abstract B45: c-MYC is a potential therapeutic target for cisplatin-resistant ovarian cancer
Ovarian cancer accounts for approximately 3% of all cancers in women. However, it is the deadliest cancer of the female reproductive system. Due to its non-specific symptoms, ovarian cancer is diagnosed at advanced stages of the disease. The most common standard treatment for advanced ovarian cancer is the platinum-based drugs such as cisplatin. However, over 70% of women relapse due to chemoresistance. Several mechanisms of cisplatin resistance have been described. However, the exact mechanism is not known. Evidence indicates that activation of the transcription factor c-MYC and its regulated genes could be involved in su...
Source: Molecular Cancer Research - October 18, 2015 Category: Cancer & Oncology Authors: Vivas-Mejia, P. E., Reyes, j., Sood, A. K. Tags: Therapeutic Translation: Poster Presentations - Proffered Abstracts Source Type: research

Abstract 680: Identification of GLI1 antagonists for breast cancer therapy
Conclusion: Several agents showed efficacy in in vitro BC cancer models demonstrating that GLI inhibitors may be a valid therapeutic approach for targeting GLI-dependent BC cancers.[1] Z. Thomas, W. Gibson, J. Sexton, K. Aird, S. Ingram, A. Aldrich, H. Lyerly, G. Devi, K. Williams, Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration. British Journal of Cancer 104 (2011) 1575-1586.[2] K.P. Williams, J.L. Allensworth, S.M. Ingram, G.R. Smith, A.J. Aldrich, J. Z Sexton, G. R Devi, Quantitative high-throughput efficacy profiling of approved oncology drugs in inflammat...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Oladapo, H., Fleming, J. M., Addo, K., Tarpley, M., Ehe, B., Ingram, S., Sauer, S., Devi, G., Williams, K. P. Tags: Experimental and Molecular Therapeutics Source Type: research

Shear Stress-Induced Mitochondrial Biogenesis Decreases the Release of Microparticles from Endothelial Cells.
Abstract The concept of enhancing structural integrity of mitochondria has emerged as a novel therapeutic option for cardiovascular disease. Flow-induced increase in laminar shear stress is a potent physiological stimulant associated with exercise which exerts atheroprotective effects in the vasculature. However, the effect of laminar shear stress on mitochondrial remodeling within the vascular endothelium and its related functional consequences remain largely unknown. Using in vitro and in vivo complementary studies, here, we report that aerobic exercise alleviates the release of endothelial microparticles in pre...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 29, 2015 Category: Physiology Authors: Kim JS, Kim B, Lee H, Thakkar S, Babbitt DM, Eguchi S, Brown MD, Park JY Tags: Am J Physiol Heart Circ Physiol Source Type: research

Abstract 4233: Mef2C enhances 1,25-dihydroxyvitamin D3-induced monocytic differentiation of human myeloid leukemia cells by regulating C/EBP{beta} expression
Myogenic enhancer factors 2 (Mef2) are members of the family of MADS (MCM1-agamous-deficiens-serum response factor)-box transcription factors known to have multiple roles in morphogenesis of skeletal, cardiac and smooth muscle cells. Recently, Mef2C was found to be also involved in hematopoiesis. Bone marrow cells isolated from Mef2C knockout mice demonstrated decreased monocytic differentiation in response to cytokine stimulation, whereas constitutive expression of Mef2C promoted monopoiesis. The above findings led us to examine the role of Mef2C in 1,25-dihydroxyvitamin D3 (1,25D)-induced monocytic differentiation. Human...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Zheng, R., Wang, X., Studzinski, G. P. Tags: Molecular and Cellular Biology Source Type: research

Abstract 4751: 25-hydroxyvitamin D3 induces vitamin D signaling independent of CYP27B1 in non-small cell lung cancer cells
Conclusions NSCLC cells expressing high levels of VDR display increased responsiveness to vitamin D metabolites. Although NSCLC cells express CYP27B1, our results demonstrate that the enzyme may not be required to achieve vitamin D signaling. Rather, 25(OH)D3 may act via the VDR to elicit an anti-tumor responses. The implication of these findings is that dietary supplementation to increase circulating 25(OH)D3 may be beneficial in a subset of NSCLC patients. Funding provided by NIH RO1 CA132844, training grant 5T32CA009072-37 and P30CA47904 Citation Format: Alissa R. Verone, Suzanne Shoemaker, Robert Parise, Jan H. Beumer,...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Verone, A. R., Shoemaker, S., Parise, R., Beumer, J. H., Hershberger, P. A. Tags: Endocrinology Source Type: research

Improved asymmetry prediction for short interfering RNAs
In the development of RNA interference therapeutics, merely selecting short interfering RNA (siRNA) sequences that are complementary to the mRNA target does not guarantee target silencing. Current algorithms for selecting siRNAs rely on many parameters, one of which is asymmetry, often predicted through calculation of the relative thermodynamic stabilities of the two ends of the siRNA. However, we have previously shown that highly active siRNA sequences are likely to have particular nucleotides at each 5′‐end, independently of their thermodynamic asymmetry. Here, we describe an algorithm for predicting highly active si...
Source: FEBS Journal - January 2, 2014 Category: Research Authors: Amanda P. Malefyt, Ming Wu, Daniel B. Vocelle, Sean J. Kappes, Stephen D. Lindeman, Christina Chan, S. Patrick Walton Tags: Original Article Source Type: research

VIRsiRNApred: a web server for predicting inhibition efficacy of siRNAs targeting human viruses
Conclusion: VIRsiRNApred is the first algorithm for predicting inhibition efficacy of viral siRNAs which is developed using experimentally verified viral siRNAs. We hope this algorithm would be useful in predicting highly potent viral siRNA to aid siRNA based antiviral therapeutics development. The web server is freely available at http://crdd.osdd.net/servers/virsirnapred/.
Source: Journal of Translational Medicine - December 11, 2013 Category: Research Authors: Abid QureshiNishant ThakurManoj Kumar Source Type: research

Improved asymmetry prediction for siRNAs
This article is protected by copyright. All rights reserved.
Source: FEBS Journal - November 1, 2013 Category: Research Authors: Amanda P. Malefyt, Ming Wu, Daniel B. Vocelle, Sean J. Kappes, Stephen D. Lindeman, Christina Chan, S. Patrick Walton Tags: Original Article Source Type: research

Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats.
Abstract Exercise training lowers blood pressure and is a recommended nonpharmacological strategy and useful adjunctive therapy for hypertensive patients. Studies demonstrate that physical activity attenuates progression of hypertension. However, underlying mechanisms remain elusive. Vascular insulin resistance and endothelial dysfunction plays a critical role in the development of hypertension. The present study investigated whether long-term physical exercise starting during the prehypertensive period prevents the development of hypertension via improving vascular insulin sensitivity. Young (4-week-old) prehyper...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 2, 2013 Category: Physiology Authors: Xing W, Li Y, Zhang H, Mi C, Hou Z, Quon MJ, Gao F Tags: Am J Physiol Heart Circ Physiol Source Type: research