Editorial board
Publication date: December 2015Source: European Journal of Cancer Supplements, Volume 13, Issue 2Author(s): (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - July 10, 2018 Category: Cancer & Oncology Source Type: research

Biosimilars: Extrapolating the evidence. A roundtable discussion
Publication date: December 2015Source: European Journal of Cancer Supplements, Volume 13, Issue 2Author(s): Bradley J. Monk, Morton Coleman, Philip Lammers, George Somlo (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - July 10, 2018 Category: Cancer & Oncology Source Type: research

Urothelial carcinoma management in elderly or unfit patients
Publication date: March 2016Source: European Journal of Cancer Supplements, Volume 14, Issue 1Author(s): Joaquim Bellmunt, Nicolas Mottet, Maria De Santis (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - July 10, 2018 Category: Cancer & Oncology Source Type: research

Editorial board
Publication date: December 2015Source: European Journal of Cancer Supplements, Volume 13, Issue 2Author(s): (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - July 5, 2018 Category: Cancer & Oncology Source Type: research

Biosimilars: Extrapolating the evidence. A roundtable discussion
Publication date: December 2015Source: European Journal of Cancer Supplements, Volume 13, Issue 2Author(s): Bradley J. Monk, Morton Coleman, Philip Lammers, George Somlo (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - July 5, 2018 Category: Cancer & Oncology Source Type: research

Urothelial carcinoma management in elderly or unfit patients
Publication date: March 2016Source: European Journal of Cancer Supplements, Volume 14, Issue 1Author(s): Joaquim Bellmunt, Nicolas Mottet, Maria De Santis (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - July 5, 2018 Category: Cancer & Oncology Source Type: research

Urothelial carcinoma management in elderly or unfit patients
Publication date: March 2016 Source:European Journal of Cancer Supplements, Volume 14, Issue 1 Author(s): Joaquim Bellmunt, Nicolas Mottet, Maria De Santis (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - March 22, 2016 Category: Cancer & Oncology Source Type: research

Biosimilars: Extrapolating the evidence. A roundtable discussion
Publication date: December 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 2 Author(s): Bradley J. Monk, Morton Coleman, Philip Lammers, George Somlo (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - January 22, 2016 Category: Cancer & Oncology Source Type: research

A75
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): D. Korobkov, N. Plotnikova, G. Meltsaev, S. Kemaykin, A. Almyashev, S. Haritonov Breast cancer is one of the most common cancers in women. The incidence of breast cancer in 2014 in the Republic of Mordovia was 69.9 per 100,000 female populations. Breast cancer occurs when excessive expression of oncoproteins switches in the case of transformation of proto-oncogene in PRADI. In primary breast tumors, mutations and the expression of the three oncogenes Her2/neu, C-mys, Int-2, as well as in supressonyh genes &n...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A122
Conclusion Expression of CD79b, CD22, CD38 is the main feature of cells with recurrent genetic injuries. Immunophenotype without expression of CD79b, CD22, CD38 in most cases differentiates CLL patients with del(13)(q14.3), del (13)(q34), (13q)(34) trisomy and with normal karyotype. Coexpression in the most of the cells of the three antigens CD79b, CD22, CD38 and more bright expression of CD20 proposes trisomy 12 or del(6q). Partial expression of CD79b and CD38 may correlate with del(11)(q23). (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P17
Conclusion Allogeneic transplantation of bone marrow cells on porous incubator was shown to prolong and enhance antitumor and antimetastatic action compared to injecting the cells. This effect is directly due to the stimulation of antitumor immunity, that is described by the study of immunity factors. The results show perspectives of porous TiNi-based scaffolds in complex treatment of neoplastic diseases. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

T35
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): F. Kisseljov, S. Vinokurova, N. Kisseljova, L. Pavlova, M. Fedorova, A. Katargin, A. Petrenko, L. Korolenkova Epigenetics investigates mechanisms that control inheritance of gene expression program during somatic cell divisions. These mechanisms include regulation by DNA methylation, histone post-translational modifications and nucleosome positioning, functioning of regulatory non-coding RNAs, control of alternative splicing of mRNA precursors and high-order chromatin organization. Genome-wide loss of epig...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A112
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): E. Kisseleva, A. Krylov, K. Rutto, V. Lioudyno Recruitment of mononuclear phagocytes from the blood into tissues is considered to be a crucial process during inflammatory reactions, wound healing and tumor growth. Macrophages are known to reveal high plasticity and may change under the influence of microenvironment. The aim of the study was to evaluate the changes of macrophage functional activity under the influence of Vascular endothelial growth factor (VEGF) in vitro. This factor is known to be the main ang...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P88
Conclusion Taking together, findings of the study will lay the fundamental groundwork for the development of novel anticancer strategies and new chemotherapy effects of small molecules. The mechanism of PARP-1 inhibition by MGBLs and its epigenetic influence on silent genes, via DNA methylation and histone modifications make reasonable further study of these compounds in three prospective directions: (1) as self-acting cytotoxic agents; (2) as a component of combined chemotherapy targeting DNA repair by PARP-1, thereby facilitating DNA damage caused by other anticancer drugs; (3) as an agents reactivating epigenetically re...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A144
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): T. Khramova, V. Varaksin, L. Beduleva, I. Menshikov Existing methods for the preoperative detection of metastases in thyroid cancer have low efficiency and highly invasive. Therefore, the searches for laboratory markers that will indicate the presence of metastases including hidden with high reliability in cancer of the thyroid gland are relevant. Immune system is one of the key mechanisms for regulation of tissue proliferation. Autoreactive lymphocytes restrict the growth and proliferation of tissues. In turn...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P69
Conclusion Exposure to TCDD induces a mechanism of two-stage regulation of the expression of some IL-12 family subunits through primary activation of the aryl hydrocarbon receptor by the TCDD-containing complex followed by ATF3-dependent suppression of their expression. This may result in an abrupt reduction of the anti-tumor response mediated by O and NK cells. The observed increase in ATF3 and decrease in IL-12 following exposure to TCDD are consistent with data on the expression of these genes in tumor-associated macrophages (TAMs). Reliance upon available data that demonstrate a decrease in IL-12 alongside an increase ...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

T15
Conclusion Neoadjuvant chemotherapy increases blood levels of circulating tumor cells, endothelial progenitor cells and mesenchymal stem cells progenitor fibroblasts, thus promoting the formation of premetastatic niche. The study was conducted with financial support from the Council for Grants of the President of the Russian Federation (Russia) for the state support of young philosophy doctors, agreements of SC 114.120.14.168-MD Russian Scientific Foundation (Russia), Grant No. 14-15-00318 (sample collection) and Russian Foundation for Basic Research (Russia), Grant No. 15-34-20864. We acknowledge support of this work by t...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P121
Conclusion Thus, if the amount of radiation exposure of BAL cells was significantly reduced by the 1st and 7th days, and after inhalation of sulfur dioxide – tended to increase, then the combined action on the 7th day it was almost half the theoretical (hypothetical) the sum of the separate effects of the studied factors. Exposure to sulfur dioxide significantly slowed the activation of cell count. It was found, that after combined action of the investigated factors the morphological characteristics of macrophages (reducing the square of cells and their nuclei) have changed (7th and 15th day). The absorption activity...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

T32
We examined racial disparities among 102 oropharyngeal carcinoma (OPC) patients (30 African Americans, 72 Whites) comparing the present of HPV16/18 E6 and E7 oncoproteins, and p16Ink4A overexpression, with times to disease progression (DP) and disease specific survival (DSS). Expression of HPV16/18 transcripts was assessed by reverse transcription and polymerase chain reaction using type-specific E6/E7 primers; p16Ink4A was evaluated by immunohistochemistry. African Americans were significantly more likely to present with high T stage disease and receive nonsurgical treatment. HPV16/18 was present in 63% of patients; no ra...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P152
In this study, we asked by using gastrointestinal stromal tumours as a model if an epigenetic related HOX Antisense Intergenic RNA, or HOTAIR, is involved in establishment of DNA methylation patterns. To this end, we first showed high up-regulation of HOTAIR in patient samples of high risk compared to low and intermediate risk groups (n =66, p =6.7×10−6), what is supported by the earlier reports on common carcinomas. Highest levels of HOTAIR endogenous expression were next detected also in cell lines GIST T1, GIST48b and GIST882. Stable knockdown of HOTAIR was achieved in GIST T1 and GIST48b cells by RNAi using...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P74
In this study we show that intracellular cycling of exo- and endogenous Hsp70s increases the sensitivity of cancer cells to cytotoxic lymphocytes. Moreover, the results of in vivo studies employing B16 mouse melanoma and C6 rat glioblastoma as targets proved the therapeutic relevance of exogenous Hsp70 in intra-tumoral application. To uncover the mechanisms of the anticancer effect we used inhibitors and markers of intra- and extracellular protein transport. The data of these studies showed multiplicity of pathways using which exo-Hsp70 reaches cytosol and more usable ones was endocytosis. To be exported intracellular Hsp7...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P20
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): V. Gurtsevitch, L. Yakovleva, L. Scherback, E. Goncharova, K. Smirnova, N. Senyuta The Epstein–Barr virus (EBV) represents an etiological agent for a number of human benign and malignant tumors. One of the EBV encoded proteins, the latent membrane protein 1 (LMP1), is involved in activation of many signaling pathways and transcription factors leading EBV infected cells to immortalization and transformation. It’s well known that almost all worlds’ population is infected with EBV. As usually,...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P68
Conclusion Apparently, the TMEPAI may be a potential biomarker of malignant transformation risk of the stomach epithelium. The presented study was financially supported by Grants from the Russian Fund for Basic Research (14-04-31500) and Tomsk State University Competitiveness Improvement Program. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P114
Conclusion The data obtained show that further studies are required to improve personalized therapy for NSCLC patients. The frequency and type of KRAS and EGFR mutations were first assessed in NSCLC patients from West Siberia. This work was supported by a Grant from the OPTEK Company (No 122/2014/51/Nvs ). (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A18
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): T. Gening, T. Abakumova, D. Dolgova, S. Gening, I. Antoneeva Tumor-associated neutrophils (TANs) are the cell population that differs in morphofunctional characteristics from peripheral blood cells (Gregory and Houghton, 2011). The first study to identify the presence of TANs as an independent poor prognostic factor and to include TANs into a prognostic risk model was published in 2006 (Donskov , 2006). Specific signals during cancer progression have been shown to induce the emergence of a pro-tumor phenotype...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A91
Conclusion One can conclude that serum procathepsin B and endogenous inhibitors of cysteine proteases cystatin B are prospective tumor biomarkers in reproductive system tumors. Procathepsin B and cystatin B seem to be important in differential diagnosis of ovarian cancer and benign ovarian tumors. Procathepsin B and cystatin B are involved in breast and endometrial cancer that warrants further investigation of their role in cancer. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

T33
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): M. Freidin Blood-derived biomarkers, such as circulating tumour cells (CTCs) and circulating tumour DNA (ctDNA), are a valuable source of molecular genetic data for tumours they spring from. In translational cancer research, the “liquid biopsy” concept has been put forward to denote the detection and molecular characterization of these biomarkers. The idea of liquid biopsy is based on a hypothesis that profiles of somatic mutations in CTCs and ctDNA are identical to those in the original tumour. There...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P119
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): R. Fadeev, M. Solovieva, S. Zakharov, I. Fadeeva, A. Senotov, A. Golenkov, V. Akatov Acute myelomonocytic leukemia (FAB M4) is one of the most common forms of acute myeloid leukemia (AML). This AML form is characterized by rapid accumulation transformed myeloblasts and monoblasts in bone marrow, with the rapid suppression of normal hematopoiesis. Bone marrow microenvironment is one of the main factors determining drug resistance of leukemic cells. It is known that the adhesion of leukemic cells to mesenchym...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P83
Conclusion The combination of nonspecific clinical signs (pain, dyspepsia) with biochemical markers of biliary pathology and endocrine pancreatic insufficiency – of PCa patients demonstrates the obligatoriness of differential diagnostic pancreatic and biliary pathology in their earlier stages. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A115
Conclusion Head and neck tumors are a rare group of clinically and biologically diverse neoplastic diseases. Among the residents of the Chelyabinsk region, men are 2–3 times more susceptible to cancer of the oral cavity and pharynx than women. High mortality rate is due to late referral of patients to specialized clinics; most head and neck cancer patients are diagnosed at advanced stages. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P127
Conclusion Genetic tests show that DNA methylation in patients with chronic atrophic gastritis has high diagnostic importance. Anti-H. pylori therapy at the different stages of “Correa” cascade has high level of induction in transforming into non invase gastric cancer. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P43
Conclusion In serum of control (healthy) group, cystatin C concentration is significantly higher than cystatin SN level in serum, tears and intraocular fluid. The reverse correlation was revealed between the level of these inhibitors in serum, that is suggested their possible interaction. In melanoma patients the reciprocal changes in cystatin C and cystatin SN were shown: increased cystatin C and decreased cystatin SN level in all biological fluids studied. On the basis of cystatins distribution in biological fluids of patients one can suggest their involvement in pathological process as system reaction of organism on tum...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P78
Conclusion Intratumor morphological heterogeneity of IC NST contributes to distant metastasis probably by variations in expression of genes involved in cell motility and pre-metastatic niche formation between different morphological structures. The study was supported by the Russian Scientific Foundation (Grant #14-15-00318 ). (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P158
Conclusion Here we present for the first time a cross-platform mass spectrometric analysis of bile juice collected from the patients cholangiocarcinoma-associated diseases. We show that a combination of the two platforms greatly improves the coverage of the metabolome and as such should be a firstchoice for exploratory studies of the complex biological matrixes. Work was conducted with the application of the Tomsk regional common use center technical equipment acquired thanks to a grant of the Russian Ministry of the Agreement No. 14.594.21.0001 (RFMEFI59414X0001). This project is supported by “The Tomsk State Univer...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A141
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): H. Davtyan, G. Hakobyan, K. Alexsanyan, Y. Tadevosyan The aim of this study was to investigate the quantitative changes in the phospholipid (PL) content of peripheral blood mononuclear cells (MNC), plasma membrane (PM), fraction in breast (BC) and cervical cancers (CC) compared to normal levels. Eight PL fractions were identified by TLC method in the PM of MNC, namely: lysophosphatidylcholines (LPC), sphingomyelins (SPM), phosphatidylcholines (PC), phosphatidylinositols (PI), phosphatidylserines (PS), phosphat...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A129
In conclusion, these data confirm previously existing assumption about paracrine effect of Igfbps on tumor growth and progression. Phosphorylation of FoxO3 protein may play an important role in survival of cancer cells. Our results showed up-regulation of Igfbp-2 and Igfbp-5 in tumor and tumor surrounding tissue. Igfbp-2 and Igfbp-5, well known activators of Igfs, can be pro-tumorigenic factors, which are important for hepatocarcinogenesis. Hence, therapeutic targeting of these proteins may offer options for intervention in human HCC. Project supported by Russian Foundation for Basic Research (Russia) No. (113-04-01459). (...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P132
Conclusions 1.It was established that in the pathogenesis of choroidal melanoma, local Inflammation plays an important role as evidenced by a significant high concentration of IL-6, IL-8 due to lower levels of IL-4 and expressed immune disorders, cell destruction, as evidenced by significantly high level of AAB to Ag of nDNA, compared with the control group. 2.Use of lacrimal liquid is suitable for the study of the inflammation, immune disorders and cell destruction at the local level in patients with choroidal melanoma. 3.Significant increase in IL-6 level in lacrimal liquid was observed for all stages of choroidal mel...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P133
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): A. Cherepanova, V. Vlassov, P. Laktionov The strong connection between cancer-related inflammation and tumour development with pattern – recognizing receptors (PRRs) activation results in identification of new target molecules that could lead to improved cancer diagnosis and treatment. TLR3, RIG1 and MDA5 synthetic ligand poly(I:C) was shown to trigger apoptosis in cancer cells. However, TLR3 signaling also includes NF-kB transcription factor which has emerged as endogenous tumour promoter via stimulation...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

T93
Conclusion The parameters of the activation of systemic and intra-tumoral immune system by growing tumor and its dissemination have to be validated in order to identify the new prognostic markers for the efficiency of the neoadjuvant chemotherapy. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P131
Conclusion Our data showed that metastasis to lymph nodes and alcohol consumption are the main factors that affect mortality in HNC patients of Tomsk region. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A111
Conclusion Quantitative changes of some components of the tumor microenvironment such as CD4+-, CD8+-, FOXP3+-lymphocytes and content of FOXP3+-tumor cells correlate with the biological characteristics of EC and apparently have a significant role in the progression of this cancer. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P67
In this study, we have investigated microvesicles and miRNA from urine of healthy donors and PCa patients. To isolate miRNAs from urine and microparticles, novel methods for miRNA isolation were elaborated (Rus. patent application No 2014137763, priority date 17.09.2014). The study population included 14 patients with PCa (63–82years, T2-3NxMx1) and control group of 20 healthy volunteers with no previous history of prostate disease (48–73years). Urine was clarified by two serial centrifugations at 400g, 20°C, 20min and at 17000g, 20°C, 20min. Microparticles were precipitated from the resulting supernata...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P70
Conclusion Thus, obtained candidate DNA-vaccine encoding target polyepitopeimmunogen provides synthesis of relevant protein in the eukaryotic cells culture. In future, we plan to study biological activity of DNA-vaccine to evaluate level of induction of cytotoxic response against SKBR3 breast cancer cells. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P124
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): A. Bondar, A. Kurilshikov, E. Morozkin, M. Zaripov, M. Kabilov, V. Voytsitskiy, V. Vlassov, P. Laktionov Cancer cells display altered methylation signatures distinguishing them from normal cells. Originating from all tissues and cells of the body cell-free DNA (cfDNA) including aberrantly methylated DNA reflect epigenetic aberrations occurs not only in tumor cells but also in tumor microenvironment. Actually, aberrantly methylated cfDNA has proved to be a promising biomarker for noninvasive detection of ca...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

T116
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): B. Biedermann The work describes advantages of our latest instrument developments in flow cytometry and microscopy. Characteristics of newly launched flow cytometer, which uses acoustic focusing to align the cells in the focus of the laser for analysis, allows to analyze samples at a much higher throughput rate without losing precision and sensitivity. This opens up new possibilities regarding sample preparation and analysis. These advantages we want to demonstrate on 2 examples, whole blood analysis and rare eve...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

A94
Conclusion This study has shown the greater development of blood and lymphatic vessels in LLSCC without keratinization in comparison with hyperkeratosis and LLSCC with keratinization, thus contributing to the development of metastasis. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P113
Conclusion G1958A SNP in the MTHFD1 gene contributes to susceptibility to NHL. The mutant allele and genotype determine the protective effect, probably, by affecting the concentration of intracellular folic acid metabolites. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P57
Conclusion As a first step in the development of GC riskometry was found that noninvasive set of serological biomarkers is an informative and non-expensive tool for the early detection of GC in population-based retrospective cohort survey in Siberian population. Low levels of PGI and PGI/PGII ratio were proven as the most valuable prognostic factors. The low level of G-17 as a single index did not significantly predict the risk of GC. (Source: European Journal of Cancer Supplements)
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

P81
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): E. Batorov, M. Tikhonova, I. Kryuchkova, V. Sergeevicheva, D. Batorova, S. Sizikova, G. Ushakova, A. Gilevich, A. Ostanin, E. Chernykh Numerous studies have shown that high-dose chemotherapy and autologous hematopoietic stem cell transplantation (AHSCT) led to a profound and long-lasting state of immunodeficiency characterized by persisting low levels of T cells in hemoblastosis patients. Well-timed T-cell reconstitution is crucial for early restoration of anti-infectious and anti- tumor immune response....
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research

T86
Publication date: November 2015 Source:European Journal of Cancer Supplements, Volume 13, Issue 1 Author(s): N. Barlev, O. Fedorova, L. Lezina, S. Piletsky Discovery of new pharmacologically active small molecules is an important and rapidly expanding area of modern molecular pharmacology. Given a limited number of proteins that are druggable, it is important to identify as many chemical effectors as possible to define the best regimen of anti-cancer therapy in each particular case. An E3 ubiquitin ligase, Mdm2, which mediates ubiquitin-dependent degradation of the critical tumor suppressor p53, is a promising target...
Source: European Journal of Cancer Supplements - November 24, 2015 Category: Cancer & Oncology Source Type: research