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Drug: Polyethylene Glycol

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Total 104 results found since Jan 2013.

Impact of pegylation on biopharmaceutical properties of dendrimers
Publication date: Available online 6 January 2015 Source:Polymer Author(s): Shrikant Thakur , Prashant Kesharwani , Rakesh K. Tekade , Narendra K. Jain In the recent years, conjugation of polyethylene glycol (PEG) on dendrimer has become an established and highly refined technology for delivery of bioactives. Dendrimers provide an ideal platform for delivery of bioactive as they represent well-defined, highly branched, nanoscale architecture with several modifiable surface groups. However, the actual potential of dendrimers is not realized due to toxicity limitations. PEG molecules are nontoxic, non-immunogenic, and non-...
Source: Polymer - January 7, 2015 Category: Chemistry Source Type: research

Effective Suppression of the Kirsten Rat Sarcoma Viral Oncogene in Pancreatic Tumor Cells via Targeted Small Interfering RNA Delivery Using Nanoparticles
Conclusions: The scFvCD44v6-conjugated nanocarriers provide a highly efficient and safe platform for systemic gene therapy for pancreatic cancer.
Source: Pancreas - February 13, 2015 Category: Gastroenterology Tags: Original Articles Source Type: research

Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer.
In this study, we evaluate the underlying mechanism by which hyperglycemia modulates the invasive potential of cancer cells and contributes to their enhanced metastatic behavior. Here we show that hyperglycemia increases the hydrogen peroxide (H2O2) concentration through up-regulation of manganese superoxide dismutase (SOD2) expression, which further activates the ERK and p38 MAPK pathways, as well as the transcription factors NF-κB and AP-1, in a time-dependent manner. The invasion of pancreatic cancer cells resulting from the activation of the H2O2/MAPK axis under high glucose conditions is effectively inhibited by PD 9...
Source: Oncotarget - October 8, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol
ACS NanoDOI: 10.1021/acsnano.7b01110
Source: ACS Nano - June 7, 2017 Category: Nanotechnology Authors: Meredith A. Jackson, Thomas A. Werfel, Elizabeth J. Curvino, Fang Yu, Taylor E. Kavanaugh, Samantha M. Sarett, Mary D. Dockery, Kameron V. Kilchrist, Ayisha N. Jackson, Todd D. Giorgio and Craig L. Duvall Source Type: research

Paraptosis ‐Inducing Nanomedicine Overcomes Cancer Drug Resistance for a Potent Cancer Therapy
Abstract Most chemotherapeutic drugs and their nanomedicine formulations exert anticancer activity by inducing cancer cell apoptosis. However, cancer cells inherently have and acquire many antiapoptosis mechanisms, causing cancer drug resistance and poor prognoses in patients. Herein, a potent paraptosis‐inducing nanomedicine is reported that causes quick nonapoptotic death of cancer cells, overcoming apoptosis‐based resistance and effectively inhibiting drug‐resistant tumor growth. The nanomedicine is composed of micelles made from an amphiphilic 8‐hydroxyquinoline (HQ)‐conjugate block copolymer with polyethylen...
Source: Small - January 1, 2018 Category: Nanotechnology Authors: Yongcun Zhou, Feiteng Huang, Ying Yang, Pingli Wang, Zhen Zhang, Yining Tang, Youqing Shen, Kai Wang Tags: Full Paper Source Type: research

Engineered Extracellular Vesicles From Human Periodontal-Ligament Stem Cells Increase VEGF/VEGFR2 Expression During Bone Regeneration
Conclusion In conclusion our results evidenced that 3D-COL/hPDLSCs/PEI-EVs may be an efficacious strategy to induce bone regeneration and vascularization of bone defects, thanks to its capacity to increase the levels of VEGF. Ethics Statement The study was performed in accordance with the guidelines of the Helsinki Declaration (2013). The written approval for the human periodontal ligament collection performed in this study has been obtained from the Medical Ethics Committee at the Medical School, “G. d’Annunzio” University of Chieti–Pescara, Chieti, Italy (n°266/17.04.14, Principal in...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Biodegradable Polyester of Poly (Ethylene glycol)-sebacic Acid as a Backbone for β-Cyclodextrin-polyrotaxane: A Promising Gene Silencing Vector.
CONCLUSION: The combinatory effect of various factors such as biodegradability, favourable complexation ability, near zero zeta potentials, good cytotoxicity properties of poly (ethylene glycol)-sebacic acid based β-Cyclodextrin-polyrotaxane makes it a potential gene delivery vector for therapeutic applications. PMID: 31393245 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - August 6, 2019 Category: Genetics & Stem Cells Authors: Ghodke S, Mahajan P, Gupta K, Ver Avadhani C, Dandekar P, Jain R Tags: Curr Gene Ther Source Type: research

Characteristics of unique endocytosis induced by weak current for cytoplasmic drug delivery
In this study, we evaluated the characteristics of WC-mediated endocytosis for application of the technology to cytoplasmic delivery of macromolecular medicines. WC induced significantly higher cellular uptake of exogenous DNA fragments compared to untreated cells; the amount increased in a time-dependent manner, indicating that endocytosis was induced after WC. Moreover, following WC treatment of cells in the presence of an antibody (MW: 150,000) with the lysosomotropic agent chloroquine, the antibody was able to bind to its intracellular target. Thus, high molecular weight protein medicines delivered by WC-mediated endoc...
Source: International Journal of Pharmaceutics - January 1, 2020 Category: Drugs & Pharmacology Source Type: research

Advantages and Challenges in nanomedicines for chronic liver diseases: a hepatologist's perspectives.
Abstract Chronic liver disease (CLD) is responsible for significant morbidity and mortality worldwide. CLD patients are at a high risk of developing progressive liver fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and subsequent liver failure. To date, there is no specific and effective therapies exist for patients with various forms of CLD. The application of nanotechnology has emerged as a rapidly developing area of interest for the safe and target-specific delivery of poorly aqueous soluble hepatoprotective agents and nucleic acids (siRNA/miRNAs) in CLD. The nanoparticle combination improves bioavailabili...
Source: European Journal of Pharmacology - December 21, 2020 Category: Drugs & Pharmacology Authors: Ezhilarasan D Tags: Eur J Pharmacol Source Type: research

Anti-inflammatory and anti-fibrotic effects of modafinil in nonalcoholic liver disease
Biomed Pharmacother. 2021 Dec;144:112372. doi: 10.1016/j.biopha.2021.112372. Epub 2021 Oct 28.ABSTRACTSmall- and intermediate-conductance Ca2+-activated K+ channels, KCa2.3 and KCa3.1, are involved in cellular signaling processes associated with inflammation and fibrosis. KCa2.3 and KCa3.1 are upregulated by proinflammatory cytokines and profibrotic growth factors. Cyclic AMP, which downregulates KCa2.3 and KCa3.1, is elevated by modafinil in cells; accordingly, we investigated whether modafinil exerts anti-inflammatory and anti-fibrotic responses via KCa2.3- and KCa3.1-mediated pathways in high-fat diet (HFD)- or thioacet...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 19, 2021 Category: Drugs & Pharmacology Authors: Shinkyu Choi Ji Aee Kim Haiyan Li Seong-Eun Jo Huisu Lee Tae Hun Kim Minje Kim Seong-Jin Kim Suk Hyo Suh Source Type: research

Molecules, Vol. 28, Pages 917: Site-Specific Antibody Conjugation with Payloads beyond Cytotoxins
u As antibody–drug conjugates have become a very important modality for cancer therapy, many site-specific conjugation approaches have been developed for generating homogenous molecules. The selective antibody coupling is achieved through antibody engineering by introducing specific amino acid or unnatural amino acid residues, peptides, and glycans. In addition to the use of synthetic cytotoxins, these novel methods have been applied for the conjugation of other payloads, including non-cytotoxic compounds, proteins/peptides, glycans, lipids, and nucleic acids. The non-cytotoxic compounds include polyethyl...
Source: Molecules - January 17, 2023 Category: Chemistry Authors: Qun Zhou Tags: Review Source Type: research

Optimizing Lipid Nanoparticles for Delivery in Primates
This article is protected by copyright. All rights reserved.PMID:36972555 | DOI:10.1002/adma.202211420
Source: Adv Data - March 27, 2023 Category: Epidemiology Authors: Kieu Lam Petra Schreiner Ada Leung Paul Stainton Steve Reid Ed Yaworski Pete Lutwyche James Heyes Source Type: research