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Condition: Atrial Fibrillation
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Total 40 results found since Jan 2013.
Mechanism of myocardial fibrosis regulation by IGF-1R in atrial fibrillation through the PI3K/Akt/FoxO3a pathway
In this study, the mechanism of IGF-1R in atrial structural remodeling was examined based on in vivo and in vitro experiments. First, cluster analysis of AF hub genes was conducted, and then the molecular mechanism was proposed by which IGF-1R regulates myocardial fibrosis via the PI3K/Akt/FoxO3a pathway. Subsequently, the mentioned mechanism was verified in human cardiac fibroblasts (HCFs) and rats transduced with IGF-1 overexpression type 9 adeno-associated viruses. The results indicated that IGF-1R activation up-regulated collagen Ⅰ protein expression and Akt phosphorylation in HCFs and rat atrium. The administration ...
Source: Biochemistry and Cell Biology - April 5, 2023 Category: Biochemistry Authors: Pei Zhang Huilin Li An Zhang Xiao Wang Qiyuan Song Zhan Li Weizong Wang Jingwen Xu Yinglong Hou Yong Zhang Source Type: research
Knockdown of Ift88 in fibroblasts causes extracellular matrix remodeling and decreases conduction velocity in cardiomyocyte monolayers
Conclusion: Disruption of cilia formation by siIft88 causes ECM remodeling and conduction abnormalities. Prevention of cilia loss could be a target for prevention of arrhythmias.
Source: Frontiers in Physiology - November 17, 2022 Category: Physiology Source Type: research
Ezh2 Inhibits Replicative Senescence of Atrial Fibroblasts Through Promotion of H3K27me3 in the Promoter Regions of CDKN2a and Timp4 Genes
CONCLUSION: These results thus indicate that Ezh2 is a key regulator of AFs' RS and this work may provide a basis for future treatments for atrial fibrosis in the elderly.PMID:35996686 | PMC:PMC9392478 | DOI:10.2147/JIR.S374951
Source: Cell Research - August 23, 2022 Category: Cytology Authors: Yingze Li Guojian Fang Wei Cao Jiali Yuan Shuai Song Hong Peng Yuepeng Wang Qunshan Wang Source Type: research
miR-181b targets semaphorin 3A to mediate TGF-β–induced endothelial-mesenchymal transition related to atrial fibrillation
Atrial fibrosis is an essential contributor to atrial fibrillation (AF). It remains unclear whether atrial endocardial endothelial cells (AEECs) that undergo endothelial-mesenchymal transition (EndMT) are among the sources of atrial fibroblasts. We studied human atria, TGF-β–treated human AEECs, cardiac-specific TGF-β–transgenic mice, and heart failure rabbits to identify the underlying mechanism of EndMT in atrial fibrosis. Using isolated AEECs, we found that miR-181b was induced in TGF-β–treated AEECs, which decreased semaphorin 3A (Sema3A) and increased EndMT markers, and these effects could be reversed by a mi...
Source: Journal of Clinical Investigation - July 1, 2022 Category: Biomedical Science Authors: Ying-Ju Lai, Feng-Chun Tsai, Gwo-Jyh Chang, Shang-Hung Chang, Chung-Chi Huang, Wei-Jan Chen, Yung-Hsin Yeh Source Type: research
Melatonin inhibits angiotensin II-induced atrial fibrillation through preventing degradation of Ang II Type I Receptor-Associated Protein (ATRAP)
In this study, Ang II was used to induce AF, and AF inducibility and duration were documented telemetrically. Ang II-infused mice had a higher AF incidence, which was associated with atrial fibrosis, inflammation, and oxidative stress. Melatonin partially inhibited these effects, and enforced expression of siRNA-ATRAP in atria counteracted the beneficial role of melatonin. Specifically, melatonin inhibited expression of Ang II-induced proteasome and immunoproteasome subunits β2, β2i, β5, and β5i as well as their corresponding trypsin-like and chymotrypsin-like activities and blocked ATRAP degradation. In turn, this inh...
Source: Biochemical Pharmacology - June 16, 2022 Category: Drugs & Pharmacology Authors: Xin Xie Ting-Ting Shen Hai-Lian Bi Zhuo-Lin Su Zi-Qi Liao Ying Zhang Lei Shi Yun-Long Xia Source Type: research
Beneficial Effect of Edoxaban on Preventing Atrial Fibrillation and Coagulation by Reducing Inflammation via HBG1/HBD Biomarkers
Conclusion: Edoxaban could prevent atrial fibrillation and coagulation by reducing inflammation, lipids, and fibrosis via HBG1/HBD biomarkers effectively, and the effect was superior to that of rivaroxaban.
Source: Frontiers in Pharmacology - June 3, 2022 Category: Drugs & Pharmacology Source Type: research
Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes
CONCLUSIONS: Kv1.5 regulates MSU-induced activation of NLRP3 inflammasome in macrophages. MSUrelated activation of NLRP3 inflammasome and electrical remodeling in HL-1 cells are via macrophages. Kv1.5 may have therapeutic value for diseases related to gout-induced activation of the NLRP3 inflammsome, including AF.PMID:35368226 | DOI:10.1007/s11033-022-07378-1
Source: Molecular Biology Reports - April 4, 2022 Category: Molecular Biology Authors: Peili Li Yasutaka Kurata Fikri Taufiq Masanari Kuwabara Haruaki Ninomiya Katsumi Higaki Motokazu Tsuneto Yasuaki Shirayoshi Miguel A Lanaspa Ichiro Hisatome Source Type: research
Honokiol Inhibits Atrial Metabolic Remodeling in Atrial Fibrillation Through Sirt3 Pathway
Conclusion and Implications: HL inhibited atrial metabolic remodeling in AF via the Sirt3 pathway. The present study may provide a novel therapeutical strategy for AF.
Source: Frontiers in Pharmacology - March 17, 2022 Category: Drugs & Pharmacology Source Type: research
