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Condition: Brain Tumor
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Total 810 results found since Jan 2013.
LncRNA HOTAIR sponges miR-301a-3p to promote glioblastoma proliferation and invasion through upregulating FOSL1
In this study, HOTAIR expression was found to be positively regulated by TRPM7, significantly upregulated in glioma tissues, and is a poor prognosis factor for glioma patients. Moreover, reduced HOTAIR expression impeded the proliferation and invasion of glioma cells. Mechanistically, HOTAIR directly interacted with miR-301a-3p, and downregulation of miR-301a-3p efficiently reversed FOSL1 suppression induced by siRNA HOTAIR, which implied that HOTAIR positively regulated FOSL1 level through sponging miR-301a-3p and played an oncogenic role in glioma progression. In contrast to HOTAIR's role, miR-301a-3p alone served as a t...
Source: Cellular Signalling - March 16, 2022 Category: Cytology Authors: Shanchun Guo Pendelton King Emily Liang Alyssa A Guo Mingli Liu Source Type: research
Targeting long non-coding RNA PVT1/TGF- β/Smad by p53 prevents glioma progression
This study discussed the impact of p53/lncRNA plasmacytoma variant translocation 1 (lncRNA PVT1)/transforming growth factor beta (TGF-β)/Smad axis on the biological characteristics of glioma. Glioma and normal tissues were collected, in which relative lncRNA PVT1 and p53 expression was assessed. Pearson's analysis was adopted for the correlation analysis between lncRNA PVT1 and p53. Short interfering RNA (siRNA) against lncRNA PVT1 (siRNA-PVT1), siRNA-p53 or both was transfected into the glioma cells to evaluate effects of lncRNA PVT1 and p53 on cell proliferation, migration, invasion, and apoptosis. Mouse xenograft model...
Source: Cancer Biology and Therapy - March 11, 2022 Category: Cancer & Oncology Authors: Zhang Li Ming Li Pengcheng Xia Lili Wang Zhiming Lu Source Type: research
Propofol inhibits proliferation and migration of glioma cells by up-regulating lncRNA GAS5
Toxicol In Vitro. 2022 Jan 24:105321. doi: 10.1016/j.tiv.2022.105321. Online ahead of print.ABSTRACTPropofol has been documented to exhibit anti-tumor effects in cancers. However, the underlying mechanisms of its inhibition remain unclear. We conducted this study to investigate the effect of propofol on lncRNA GAS5 in glioma cells, and to probe the role of GAS5 in the anti-tumor effects of propofol. Human glioma cell line U251 were treated with propofol. Cell proliferation, migration, invasion, cell cycle and apoptosis were evaluated, and the expression of GAS5 was measured. After that, we knockdown the expression of GAS5 ...
Source: Toxicology in Vitro - January 27, 2022 Category: Toxicology Authors: Yan Cheng Lina Zheng Haiyun Wang Chenyi Yang Weiwei Zhang Source Type: research
SHMT1 siRNA-Loaded hyperosmotic nanochains for blood-brain/tumor barrier post-transmigration therapy
Biomaterials. 2021 Dec 30;281:121359. doi: 10.1016/j.biomaterials.2021.121359. Online ahead of print.ABSTRACTThe near-perivascular accumulation in solid tumors and short-lived span in circulation, derails even the most competent nanoparticles (NPs) from achieving their maximum therapeutic potential. Moreover, delivering them across the blood brain/tumor barrier (BBB/BTB) is further challenging to sought anticancer effect. To address these key challenges, we designed a linearly aligned nucleic acid-complexed polydixylitol-based polymeric nanochains (X-NCs), with inherent hyperosmotic properties enabling transmigration of th...
Source: Biomaterials - January 8, 2022 Category: Materials Science Authors: Shambhavi Pandey Myung Chul Lee Jae Woon Lim Yun-Hoon Choung Kyoung-Je Jang Sang Bae Park Jae Eun Kim Jong Hoon Chung Pankaj Garg Source Type: research
Enhanced nose-to-brain delivery of siRNA using hyaluronan-enveloped nanomicelles for glioma therapy
In conclusion, HA/DP7-C is a potential intranasal delivery system for siRNAs in glioma therapy.PMID:34973309 | DOI:10.1016/j.jconrel.2021.12.034
Source: Cancer Control - January 1, 2022 Category: Cancer & Oncology Authors: YuLing Yang XueYan Zhang SiWen Wu Rui Zhang BaiLing Zhou XiaoYu Zhang Lin Tang Yaomei Tian Ke Men Li Yang Source Type: research
A Nanoparticle-Conjugated Anti-TBK1 siRNA Induces Autophagy-Related Apoptosis and Enhances cGAS-STING Pathway in GBM Cells
CONCLUSION: The rGO-PEG could be an efficient system facilitating the delivery of specific siRNA. TBK1si/rGO-PEG could be a novel strategy for the treatment of GBM.PMID:34931127 | PMC:PMC8684524 | DOI:10.1155/2021/6521953
Source: Evidence-based Complementary and Alternative Medicine - December 21, 2021 Category: Complementary Medicine Authors: Shengchao Xu Xi Yan Lu Tang Gan Dai Chengke Luo Source Type: research
