Filtered By:
Condition: Brain Tumor
This page shows you your search results in order of date. This is page number 12.
Order by Relevance | Date
Total 810 results found since Jan 2013.
Interference of P2X4 receptor expression in tumor-associated macrophages suppresses migration and invasion of glioma cells
CONCLUSION: Interference of P2X4 receptor in the TAMs suppresses the migration and invasion of glioma cells possibly by lowering the expressions of IL-1β and IL-18.PMID:35673908 | PMC:PMC9178632 | DOI:10.12122/j.issn.1673-4254.2022.05.05
Source: Journal of Southern Medical University - June 8, 2022 Category: Universities & Medical Training Authors: X Yang H Shen Q Li Z Dai R Yang G Huang R Chen F Wang J Song H Hua Source Type: research
STAT3 suppresses the AMPK α/ULK1-dependent induction of autophagy in glioblastoma cells
In this study, we found Serine-727 and Tyrosine-705 phosphorylation of STAT3 was constitutive in GBM cell lines. Tyrosine phosphorylation of STAT3 in GBM cells suppresses autophagy, whereas knockout (KO) of STAT3 increases ULK1 gene expression, increases TSC2-AMPKα-ULK1 signalling, and increases lysosomal Cathepsin D processing, leading to the stimulation of autophagy. Rescue of STAT3-KO cells by the enforced expression of wild-type (WT) STAT3 reverses these pathways and inhibits autophagy. Conversely, expression of Y705F- and S727A-STAT3 phosphorylation deficient mutants in STAT3-KO cells did not suppress autophagy. Inhi...
Source: J Cell Mol Med - June 7, 2022 Category: Molecular Biology Authors: Sujoy Bhattacharya Jinggang Yin Chuanhe Yang Yinan Wang Michelle Sims Lawrence M Pfeffer Edward Chaum Source Type: research
