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Condition: Brain Tumor
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Total 810 results found since Jan 2013.
Rewiring of lactate-IL-1 β auto-regulatory loop with Clock-Bmal1: A feed-forward circuit in glioma
Mol Cell Biol. 2021 Jun 14:MCB0044920. doi: 10.1128/MCB.00449-20. Online ahead of print.ABSTRACTDe-synchronized circadian rhythm in tumors is coincident with aberrant inflammation and dysregulated metabolism. As their inter-relationship in cancer etiology is largely unknown, we investigated the link between the three in glioma. Tumor metabolite lactate- mediated increase in pro-inflammatory cytokine IL-1β was concomitant with elevated levels of core circadian regulators Clock and Bmal1. siRNA mediated knockdown of Bmal1 and Clock decreased (i) LDHA and IL-1β levels and (ii) release of lactate and pro-inflammatory cytokin...
Source: Mol Biol Cell - June 14, 2021 Category: Molecular Biology Authors: Pruthvi Gowda Kirti Lathoria Shalini Sharma Shruti Patrick Sonia B Umdor Ellora Sen Source Type: research
CDK-associated Cullin 1 promotes Cell Proliferation and inhibits Cell Apoptosis in Human Glioblastoma
CONCLUSION: CACUL1 can promote cell proliferation and suppress apoptosis of glioma cells and might serve as a potential oncogene for gliomas.PMID:34080964 | DOI:10.2174/1568009621666210602164225
Source: Current Cancer Drug Targets - June 3, 2021 Category: Cancer & Oncology Authors: Xiaohua Zhang Tianying Zhang Xiaojuan Han Zhongying Qiu Jianghong Cheng Xingchun Gao Xingchun Gou Source Type: research
The enzyme L-isoaspartyl (D-aspartyl) methyltransferase promotes migration and invasion in human U-87 MG and U-251 MG glioblastoma cell lines
Biomed Pharmacother. 2021 May 31;140:111766. doi: 10.1016/j.biopha.2021.111766. Online ahead of print.ABSTRACTThe protein L-isoaspartyl (D-aspartyl) methyltransferase (PIMT) recognizes abnormal L-isoaspartyl and D-aspartyl residues in proteins. Among examined tissues, PIMT shows the highest level in the brain. The U-87 MG cell line is a commonly used cellular model to study the most frequent brain tumor, glioblastoma. Previously, we reported that PIMT amount increased when U-87 MG cells were detached from the extracellular matrix. Recently, we also showed that PIMT possessed pro-angiogenic properties. Together, these PIMT ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 3, 2021 Category: Drugs & Pharmacology Authors: Fatima Belkourchia Richard R Desrosiers Source Type: research
Hypoxia-induced phenotypic transition from highly invasive to less invasive tumors in glioma stem-like cells: Significance of CD44 and osteopontin as therapeutic targets in glioblastoma
Transl Oncol. 2021 May 27;14(8):101137. doi: 10.1016/j.tranon.2021.101137. Online ahead of print.ABSTRACTThe poor prognosis of glioblastoma multiforme (GBM) is primarily due to highly invasive glioma stem-like cells (GSCs) in tumors. Upon GBM recurrence, GSCs with highly invasive and highly migratory activities must assume a less-motile state and proliferate to regenerate tumor mass. Elucidating the molecular mechanism underlying this transition from a highly invasive phenotype to a less-invasive, proliferative tumor could facilitate the identification of effective molecular targets for treating GBM. Here, we demonstrate t...
Source: Translational Oncology - May 30, 2021 Category: Cancer & Oncology Authors: Masahiro Nishikawa Akihiro Inoue Takanori Ohnishi Hajime Yano Saya Ozaki Yonehiro Kanemura Satoshi Suehiro Yoshihiro Ohtsuka Shohei Kohno Shiro Ohue Seiji Shigekawa Hideaki Watanabe Riko Kitazawa Junya Tanaka Takeharu Kunieda Source Type: research
ERK-CREB pathway is involved in HSPB8-mediated glioma cell growth and metastatic properties
CONCLUSION: Silencing HSPB8 can inhibit the malignant features, while facilitate the apoptosis of glioma cells, with inactivation of ERK-CREB pathway.PMID:34043982 | DOI:10.1016/j.yexmp.2021.104653
Source: Experimental and Molecular Pathology - May 27, 2021 Category: Pathology Authors: Xia Li Cui Sun Jing Chen Ji-Fen Ma Yi-Heng Pan Source Type: research
