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Condition: G6PD

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Total 24 results found since Jan 2013.

Nrf2 inhibition sensitizes cholangiocarcinoma cells to cytotoxic and antiproliferative activities of chemotherapeutic agents
Abstract Nuclear factor erythroid 2-related factor 2 (Nrf2), a key transcription factor regulating antioxidant, cytoprotective, and metabolic enzymes, plays important roles in drug resistance and proliferation in cancer cells. The present study was aimed to examine the expression of Nrf2 in connection with chemotherapeutic drug sensitivity on cholangiocarcinoma (CCA) cells. The basal levels of Nrf2 protein in cytosol and nuclear fractions of CCA cells were determined using Western blot analysis. Nrf2 mRNA expression of KKU-M156 and KKU-100 cells, representatives of low and high-Nrf2-expressing CCA cells, were sile...
Source: Tumor Biology - March 24, 2016 Category: Cancer & Oncology Source Type: research

miR-1 inhibits progression of high-risk papillomavirus-associated human cervical cancer by targeting G6PD.
Authors: Hu T, Chang YF, Xiao Z, Mao R, Tong J, Chen B, Liu GC, Hong Y, Chen HL, Kong SY, Huang YM, Xiyang YB, Jin H Abstract Ectopic glucose-6-phosphate dehydrogenase (G6PD) expression may contribute to tumorigenesis in cervical cancer associated with high-risk human papillomavirus (HR-HPV 16 and 18) infections. Here, we demonstrate that microRNA-1 (miR-1) in association with AGO proteins targets G6PD in HR-HPV-infected human cervical cancer cells. miR-1 inhibited expression of a reporter construct containing a putative G6PD 3'-UTR seed region and suppressed endogenous G6PD expression. Down-regulation of miR-1 inc...
Source: Oncotarget - November 20, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Silencing of the pentose phosphate pathway genes influences DNA replication in human fibroblasts.
Abstract Previous reports and our recently published data indicated that some enzymes of glycolysis and the tricarboxylic acid cycle can affect the genome replication process by changing either the efficiency or timing of DNA synthesis in human normal cells. Both these pathways are connected with the pentose phosphate pathway (PPP pathway). The PPP pathway supports cell growth by generating energy and precursors for nucleotides and amino acids. Therefore, we asked if silencing of genes coding for enzymes involved in the pentose phosphate pathway may also affect the control of DNA replication in human fibroblasts. ...
Source: Gene - September 5, 2017 Category: Genetics & Stem Cells Authors: Fornalewicz K, Wieczorek A, Węgrzyn G, Łyżeń R Tags: Gene Source Type: research

L-Cysteine in vitro can restore cellular glutathione and inhibits the expression of cell adhesion molecules in G6PD-deficient monocytes.
Abstract L-Cysteine is a precursor of glutathione (GSH), a potent physiological antioxidant. Excess glucose-6-phosphate dehydrogenase (G6PD) deficiency in African Americans and low levels of L-cysteine diet in Hispanics can contributes to GSH deficiency and oxidative stress. Oxidative stress and monocyte adhesion was considered to be an initial event in the progression of vascular dysfunction and atherosclerosis. However, no previous study has investigated the contribution of GSH/G6PD deficiency to the expression of monocyte adhesion molecules. Using human U937 monocytes, this study examined the effect of GSH/G6PD...
Source: Amino Acids - April 6, 2018 Category: Biochemistry Authors: Parsanathan R, Jain SK Tags: Amino Acids Source Type: research

LncRNA GAS5 regulates redox balance and dysregulates the cell cycle and apoptosis in malignant melanoma cells
ConclusionsOur findings show GAS5 contributes to regulation of the apoptosis, cell cycle, homeostasis of reactive oxygen species, and redox balance in MM cells, and suggest that reduced GAS5 expression contributes to disease progression in MM patients.
Source: Journal of Cancer Research and Clinical Oncology - December 19, 2018 Category: Cancer & Oncology Source Type: research

Glucose-6-phosphate dehydrogenase deficiency increases cell adhesion molecules and activates human monocyte-endothelial cell adhesion: Protective role of l-cysteine.
Abstract Glucose-6-phosphate dehydrogenase is a major enzyme that supplies the reducing agent nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), which is required to recycle oxidized/glutathione disulfide (GSSH) to reduced glutathione (GSH). G6PD-deficient cells are susceptible to oxidative stress and a deficiency of GSH. Endothelial dysfunction is characterized by the loss of nitric oxide (NO) bioavailability, which regulates leukocyte adhesion to endothelium. G6PD-deficient endothelial cells (EC) demonstrate a reduced expression of endothelial nitric oxide synthase (eNOS) and NO levels along with redu...
Source: Archives of Biochemistry and Biophysics - December 21, 2018 Category: Biochemistry Authors: Parsanathan R, Jain SK Tags: Arch Biochem Biophys Source Type: research

6-aminonicotinamide ameliorates pulmonary fibrosis by suppressing the TGF-beta1 activated Smad signalling pathway
Conclusions: Our findings indicate that inhibition of G6PD may have anti-fibrotic effects on pulmonary fibrosis, suggesting that G6PD is implicated as a potential therapeutic target in IPF.Figure: Comparison of hydroxyproline levels in the bleomycin induced lung fibrosis mouse model according to the treatment
Source: European Respiratory Journal - October 28, 2020 Category: Respiratory Medicine Authors: Kim, M., Kim, H.-S., Moon, S.-J., Yoo, H. J., Song, J. W. Tags: Mechanisms of lung injury and repair Source Type: research

Dual inhibition of CPT1A and G6PD suppresses glioblastoma tumorspheres
ConclusionOur collective findings support the utility of dual suppression of CPT1A and G6PD with selective inhibitors, etomoxir and DHEA, as an efficacious therapeutic approach for GBM.
Source: Journal of Neuro-Oncology - November 17, 2022 Category: Cancer & Oncology Source Type: research

A cellular senescence-related genes model allows for prognosis and treatment stratification of hepatocellular carcinoma: A bioinformatics analysis and experimental verification
Conclusion: We established a cellular senescence-based stratified model, and a multivariable-based nomogram, which could predict the survival of HCC patients and guide clinical treatment.
Source: Frontiers in Genetics - January 12, 2023 Category: Genetics & Stem Cells Source Type: research