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Condition: Endometriosis
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Total 104 results found since Jan 2013.
Effect of Wnt/ β-catenin signal pathway on of matrix metalloproteinase-7 and vascular endothelial growth factor gene expressions in endometriosis.
CONCLUSION: Blocking of Wnt/β-catenin signal pathway caused the decrease of MMP-7 and VEGF expressions, in- dicating that Wnt/β-catenin signal pathway plays an important role in the adhesion, invasion, and metastasis of endometriosis tissues.
PMID: 29734552 [PubMed]
Source: Clinical and Experimental Obstetrics and Gynecology - May 10, 2018 Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research
Non-coding RNAs in endometriosis: a narrative review
AbstractBACKGROUNDEndometriosis is a benign gynaecological disorder, which affects 10% of reproductive-aged women and is characterized by endometrial cells from the lining of the uterus being found outside the uterine cavity. However, the pathophysiological mechanisms causing the development of this heterogeneous disease remain enigmatic, and a lack of effective biomarkers necessitates surgical intervention for diagnosis. There is international recognition that accurate non-invasive diagnostic tests and more effective therapies are urgently needed. Non-coding RNA (ncRNA) molecules, which are important regulators of cellula...
Source: Human Reproduction Update - April 25, 2018 Category: OBGYN Source Type: research
Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis
In conclusion, DRIAs inhibit cellular proliferation in endometriosis, thus representing a potential therapeutic option for the management of endometriosis.
Source: The Journal of Steroid Biochemistry and Molecular Biology - April 18, 2018 Category: Biochemistry Source Type: research
Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis
This study was funded by the Academy of Finland and by Tekes: Finnish Funding Agency for Innovation. The authors have no conflict of interest to declare.
Source: Human Reproduction - February 15, 2018 Category: Reproduction Medicine Source Type: research
Decreased expression of FOXA2 promotes eutopic endometrial cell proliferation and migration in patients with endometriosis
In conclusion, these findings indicate that FOXA2 might be a progesterone-induced gene, which may participate in the ‘metastatic’ process of eutopic endometrium to ectopic loci in patients with endometriosis.
Source: Reproductive BioMedicine Online - December 5, 2017 Category: Reproduction Medicine Source Type: research
Targeting hypoxia ‐mediated YAP1 nuclear translocation ameliorates pathogenesis of endometriosis without compromising maternal fertility
Abstract
Endometriosis is a highly prevalent gynecological disease that severely reduces women's health and quality of life. Ectopic endometriotic lesions have evolved mechanisms to survive in the hypoxic peritoneal microenvironment by regulating the expression of a significant subset of genes. However, the master regulator controlling these genes remains to be characterized. Herein, by using bioinformatics analysis and experimental verification, we identified Yes‐Associated Protein 1 (YAP1) as a master regulator of endometriosis. Nuclear localization and transcriptional activity of YAP1 was upregulated by hypoxia via do...
Source: The Journal of Pathology - June 12, 2017 Category: Pathology Authors: Shih ‐Chieh Lin, Hsiu‐Chi Lee, Pei‐Chi Hou, Jhao‐Lin Fu, Meng‐Hsing Wu, Shaw‐Jenq Tsai Tags: Original Paper Source Type: research
Hypoxia-inducible factor-1{alpha} promotes endometrial stromal cells migration and invasion by upregulating autophagy in endometriosis
Endometriosis is a benign gynecological disease that shares some characteristics with malignancy like migration and invasion. It has been reported that both hypoxia-inducible factor-1α (HIF-1α) and autophagy were upregulated in ectopic endometrium of patients with ovarian endometriosis. However, the crosstalk between HIF-1α and autophagy in the pathogenesis of endometriosis remains to be clarified. Accordingly, we investigated whether autophagy was regulated by HIF-1α, as well as whether the effect of HIF-1α on cell migration and invasion is mediated through autophagy upregulation. Here, we fo...
Source: Reproduction - April 25, 2017 Category: Reproduction Medicine Authors: Liu, H., Zhang, Z., Xiong, W., Zhang, L., Xiong, Y., Li, N., He, H., Du, Y., Liu, Y. Tags: Research Source Type: research
ID2 mediates the transforming growth factor-{beta}1-induced Warburg-like effect seen in the peritoneum of women with endometriosis
STUDY QUESTION
Is inhibitor of DNA-binding protein 2 (ID2) a mediator of the transforming growth factor (TGF)-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis?
SUMMARY ANSWER
The TGF-β1-induced changes in the metabolic phenotype of peritoneal mesothelial cells from women with endometriosis are mediated through the ID2 pathway.
WHAT IS KNOWN ALREADY
TGF-β1 induces the metabolic conversion of glucose to lactate via aerobic glycolysis (the ‘Warburg effect’) in the peritoneum of women with endometriosis, through increased expression of the transcription factor hypox...
Source: Molecular Human Reproduction - September 6, 2016 Category: Molecular Biology Authors: Young, V. J., Ahmad, S. F., Brown, J. K., Duncan, W. C., Horne, A. W. Tags: Original article Source Type: research
17 {beta}-Estradiol promotes vascular endothelial growth factor expression via the Wnt/{beta}-catenin pathway during the pathogenesis of endometriosis
STUDY HYPOTHESIS
Do estrogen and Wnt/β-catenin signaling promote vascular endothelial growth factor (VEGF) expression in endometriosis and how?
STUDY FINDING
17β-Estradiol (E2)-drives β-catenin triggered up-regulation of VEGF in effector human primary endometrial stromal cells (ESCs) and thus enhances their ability to establish a new blood supply to the human exfoliated endometrium.
WHAT IS KNOWN ALREADY
Implantation and survival of exfoliated endometrium is crucially dependent on neovascularization and Wnt/β-catenin signaling plays an important role in stimulating angiogenesis.
STUDY DESIGN, SAMPLES...
Source: Molecular Human Reproduction - July 11, 2016 Category: Molecular Biology Authors: Zhang, L., Xiong, W., Xiong, Y., Liu, H., Liu, Y. Tags: Original Research Source Type: research
Overexpression of chloride channel-3 is associated with the increased migration and invasion ability of ectopic endometrial cells from patients with endometriosis
STUDY QUESTION
Is chloride channel-3 (ClC-3) involved in regulating the biological behavior of endometrial stromal cells (ESCs)?
SUMMARY ANSWER
ClC-3 promotes endometriotic cell migration and invasion.
WHAT IS KNOWN ALREADY
ClC-3 plays a significant role in the migration and invasion of various kinds of cells.
STUDY DESIGN, SIZE, DURATION
An in vitro investigation of the effect of ClC-3 on the migration and invasion of ectopic ESCs from patients with endometriosis.
PARTICIPANTS/MATERIALS, SETTING, METHODS
The ectopic and eutopic endometrial samples from 43 female patients with endometriosis and the endometrial samples ...
Source: Human Reproduction - April 20, 2016 Category: Reproduction Medicine Authors: Guan, Y.-t., Huang, Y.-q., Wu, J.-b., Deng, Z.-q., Wang, Y., Lai, Z.-y., Wang, H.-b., Sun, X.-x., Zhu, Y.-l., Du, M.-m., Zhu, L.-y., Chen, L.-x., Wang, L.-w. Tags: Gynaecology Source Type: research
The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells.
Authors: Shimada H, Satohisa S, Kohno T, Takahashi S, Hatakeyama T, Konno T, Tsujiwaki M, Saito T, Kojima T
Abstract
Lipolysis-stimulated lipoprotein receptor (LSR) has been identified as a novel molecular constituent of tricellular contacts that have a barrier function for the cellular sheet. LSR recruits tricellulin (TRIC), which is the first molecular component of tricellular tight junctions. Knockdown of LSR increases cell motility and invasion of certain cancer cells. However, the behavior and the roles of LSR in endometrial cancer remain unknown. In the present study, we investigated the behavior and roles of...
Source: Oncotarget - April 3, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Elevated phosphatase of regenerating liver 3 (PRL-3) promotes cytoskeleton reorganization, cell migration and invasion in endometrial stromal cells from endometrioma
STUDY QUESTION
Is phosphatase of regenerating liver-3 (PRL-3) associated with increased motility of endometriotic cells from endometrioma?
SUMMARY ANSWER
Elevated PRL-3 promotes cytoskeleton reorganization, cell migration and invasion of endometrial stromal cells (ESCs) from endometrioma.
WHAT IS KNOWN ALREADY
Overexpression of PRL-3 is associated with cancer cell migration, invasion and metastatic phenotype.
STUDY DESIGN, SIZE, DURATION
Primary human ESCs were isolated from eutopic endometrium of women without endometriosis (EuCo, n = 10), with histologically proven endometrioma (EuEM, n = 19) and from the cyst wall of...
Source: Human Reproduction - March 15, 2016 Category: Reproduction Medicine Authors: Zhan, H., Ma, J., Ruan, F., Bedaiwy, M. A., Peng, B., Wu, R., Lin, J. Tags: Gynaecology Source Type: research
Deletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice.
Abstract
Women with endometriosis can suffer from decreased fecundity or complete infertility via abnormal oocyte function or impaired placental-uterine interactions required for normal pregnancy establishment and maintenance. Although AT-rich interactive domain 1A (SWI-like) (ARID1A) is a putative tumor suppressor in human endometrial cancers and endometriosis-associated ovarian cancers, little is known about its role in normal uterine function. To study the potential function of ARID1A in the female reproductive tract, we generated mice with a conditional knockout of Arid1a using anti-Müllerian hormone receptor...
Source: Biology of Reproduction - March 9, 2016 Category: Reproduction Medicine Authors: Wang X, Khatri S, Broaddus R, Wang Z, Hawkins SM Tags: Biol Reprod Source Type: research
c-Fos-Regulated Matrix Metalloproteinase-9 Expression is Involved in 17ß-Estradiol-Promoted Invasion of Human Endometrial Stromal Cell.
This study investigates the effect of 17β-estradiol (E2) on human endometrial stromal cell (HESC) invasion and the role of c-fos and matrix metalloproteinase-9 (MMP-9) in mediating the biological function of 17β-E2. It is found that 17β-E2 promotes not only HESC invasion, but also c-fos and MMP-9 expression in HESC. Further experiments demonstrate that the estrogen receptor inhibitor ICI 182780 and siRNA-mediated c-fos or MMP-9 knockdown are able to block the effect of 17β-E2 on HESC invasion. Moreover, siRNA-mediated c-fos knockdown suppresses the effect of 17β-E2 on MMP-9 expression. Our results indicate that 17β-E...
Source: Current Molecular Medicine - February 25, 2016 Category: Molecular Biology Authors: Pan H, Zhang P, Li JR, Wang H, Jin MF, Feng C, Huang HF Tags: Curr Mol Med Source Type: research
cAMP-Response Element-Binding 3-like protein 1 (CREB3L1) is required for decidualization and its expression is decreased in women with endometriosis.
In this study, we validated progesterone (P4) regulation of Creb3l1 in the uteri of wild-type and progesterone receptor knockout (PRKO) mice. Furthermore, we observed that CREB3L1 expression was significantly higher in secretory phase human endometrium compared to proliferative phase and that CREB3L1 expression was significantly decreased in the endometrium of women with endometriosis. Lastly, by transfecting CREB3L1 siRNA into cultured human endometrial stromal cells (hESCs) prior to hormonal induction of in vitro decidualization, we showed that CREB3L1 is required for the decidualization process. Interestingly, phosphory...
Source: Current Molecular Medicine - February 25, 2016 Category: Molecular Biology Authors: Ahn JI, Yoo JY, Kim TH, Kim YI, Ferguson SD, Fazleabas AT, Young SL, Lessey BA, Ahn JY, Lim JM, Jeong JW Tags: Curr Mol Med Source Type: research
