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Condition: Mitochondrial Disease
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Total 454 results found since Jan 2013.
Decreased IFT88 expression with primary cilia shortening causes mitochondrial dysfunction in cisplatin-induced tubular injury
Am J Physiol Renal Physiol. 2021 Aug 2. doi: 10.1152/ajprenal.00673.2020. Online ahead of print.ABSTRACTThe relevance of primary cilia shortening in kidney disease and its pathomechanism are largely unknown. Tubular damage in acute kidney injury (AKI) is strongly associated with mitochondrial dysfunction. Thus, we investigated the interaction between primary cilia and mitochondria in cisplatin-induced AKI mouse models. We observed that the expression of intraflagellar transport 88 (IFT88), a ciliary maintenance protein, was decreased in the renal cortex following tubular damage due to cisplatin-induced AKI. This result was...
Source: American Journal of Physiology. Renal Physiology - August 2, 2021 Category: Physiology Authors: Rie Fujii Sho Hasegawa Hiroshi Maekawa Tsuyoshi Inoue Kentaro Yoshioka Rie Uni Yoichiro Ikeda Masaomi Nangaku Reiko Inagi Source Type: research
Thymosin beta 4 alleviates non-alcoholic fatty liver by inhibiting ferroptosis via up-regulation of GPX4
This study revealed that Tβ4 protects hepatocytes by inhibiting the GPX4-mediated ferroptosis pathway, which provides a new strategy and target for the treatment of NAFLD.PMID:34280397 | DOI:10.1016/j.ejphar.2021.174351
Source: European Journal of Pharmacology - July 19, 2021 Category: Drugs & Pharmacology Authors: Zixin Zhu Ya Zhang Xinhao Huang Li Can Xueke Zhao Yinghui Wang Jing Xue Mingliang Cheng Lili Zhu Source Type: research
Targeting Tristetraprolin Expression or Functional Activity Regulates Inflammatory Response Induced by MSU Crystals
The RNA-binding protein tristetraprolin (TTP) is an anti-inflammatory factor that prompts the mRNA decay of target mRNAs and is involved in inflammatory diseases such as rheumatoid arthritis (RA). TTP is regulated by phosphorylation, and protein phosphatase 2A (PP2A) can dephosphorylate TTP to activate its mRNA-degrading function. Some small molecules can enhance PP2A activation. Short interfering RNA (siRNA) targeting TTP expression or PP2A agonist (Arctigenin) was administered to monosodium urate (MSU) crystal-induced J774A.1 cells, and the expression of inflammatory related genes was detected by RT-PCR and Western blot ...
Source: Frontiers in Immunology - July 16, 2021 Category: Allergy & Immunology Source Type: research
MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell in chronic obstructive pulmonary disease
This study investigated MAPK15-ULK1 signaling in airway epithelial cells of COPD patients and its activation by cigarette smoke extract (CSE) in isolated human airway epithelial cells. Significant increased phosphorylation of MAPK15 and ULK1 (Ser555) was detected in the airway epithelium of COPD patients. This pathology was maintained in isolated primary COPD-epithelial cells. Compared to control cells, the protein expression of Beclin1 and the ratio of LC3II to LC3I were both significantly increased in COPD-epithelial cells. In human airway epithelial cells, CSE significantly increased the phosphorylation of MAPK15, ULK1 ...
Source: Free Radical Biology and Medicine - July 5, 2021 Category: Biology Authors: Ming Zhang Lei Fang Liang Zhou Antonio Molino Maria Rosaria Valentino Shuanying Yang Jie Zhang Yali Li Michael Roth Source Type: research
Bawei Chenxiang Wan Ameliorates Cardiac Hypertrophy by Activating AMPK/PPAR- α Signaling Pathway Improving Energy Metabolism
In conclusion, BCW prevents ISO-induced cardiomyocyte hypertrophy by activating AMPK/PPAR-α to alleviate the disturbance in energy metabolism. Therefore, BCW can be used as an alternative drug for the treatment of cardiac hypertrophy.
Source: Frontiers in Pharmacology - June 3, 2021 Category: Drugs & Pharmacology Source Type: research
Machine learning algorithms reveal the secrets of mitochondrial dynamics
EMBO Mol Med. 2021 May 27:e14316. doi: 10.15252/emmm.202114316. Online ahead of print.ABSTRACTMitochondria exist as dynamic networks whose morphology is driven by the complex interplay between fission and fusion events. Failure to modulate these processes can be detrimental to human health as evidenced by dominantly inherited, pathogenic variants in OPA1, an effector enzyme of mitochondrial fusion, that lead to network fragmentation, cristae dysmorphology and impaired oxidative respiration, manifesting typically as isolated optic atrophy. However, a significant number of patients develop more severe, systemic phenotypes, a...
Source: Molecular Medicine - May 27, 2021 Category: Molecular Biology Authors: Jack J Collier Robert W Taylor Source Type: research
Lipotoxicity reduces DDX58/Rig-1 expression and activity leading to impaired autophagy and cell death
This study uncovers the unexpected role of immune surveillance protein DDX58/Rig-1 (DExD/H box helicase 58) in activating macroautophagy/autophagy and protecting from lipotoxicity associated with NAFLD. Here we show for the first time that DDX58 protein is significantly reduced in nonalcoholic steatohepatitis (NASH) mouse model, an aggressive form of NAFLD characterized by inflammation and fibrosis of the liver. In addition to decreased expression of DDX58, we found that DDX58 activity can be attenuated by treatments with palmitic acid (PA), a saturated fatty acid. To investigate whether PA inhibition of DDX58 is harmful t...
Source: Autophagy - May 10, 2021 Category: Cytology Authors: Karla K Frietze Alyssa M Brown Dividutta Das Raymond G Franks Jessie Lee Cunningham Michael Hayward Joseph T Nickels Source Type: research
Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPAR α Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development
Conclusions: This study explored potential drivers of vein graft inflammation and identified PPARα as a novel potential pharmacologic treatment for this unmet medical need.PMID:33821665 | DOI:10.1161/CIRCULATIONAHA.119.043724
Source: Circulation - April 6, 2021 Category: Cardiology Authors: Julius L Decano Sasha A Singh Cau ê Gasparotto Bueno Lang Ho Lee Arda Halu Sarvesh Chelvanambi Joan T Matamalas Hengmin Zhang Andrew K Mlynarchik Jiao Qiao Amitabh Sharma Shin Mukai Jianguo Wang Daniel G Anderson C Keith Ozaki Peter Libby Elena Aikawa Ma Source Type: research
Discovery and Pharmacological Evaluation of STEAP4 as a Novel Target for HER2 Overexpressing Breast Cancer
In conclusion, STEAP4 may represent a novel BC related biomarker and a potential pharmacological target for the treatment of HER2 overexpressing BC.
Source: Frontiers in Oncology - March 26, 2021 Category: Cancer & Oncology Source Type: research
