Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease PPAR α Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development

Conclusions: This study explored potential drivers of vein graft inflammation and identified PPARα as a novel potential pharmacologic treatment for this unmet medical need.PMID:33821665 | DOI:10.1161/CIRCULATIONAHA.119.043724

Source: Circulation - April 6, 2021 Category: Cardiology Authors: Julius L Decano Sasha A Singh Cau ê Gasparotto Bueno Lang Ho Lee Arda Halu Sarvesh Chelvanambi Joan T Matamalas Hengmin Zhang Andrew K Mlynarchik Jiao Qiao Amitabh Sharma Shin Mukai Jianguo Wang Daniel G Anderson C Keith Ozaki Peter Libby Elena Aikawa Ma Source Type: research