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Targeting m6A reader YTHDF1 augments antitumour immunity and boosts anti-PD-1 efficacy in colorectal cancer
Conclusion YTHDF1 impairs antitumour immunity via an m6A-p65-CXCL1/CXCR2 axis to promote CRC and serves as a therapeutic target in immune checkpoint blockade therapy.
Source: Gut - July 6, 2023 Category: Gastroenterology Authors: Bao, Y., Zhai, J., Chen, H., Wong, C. C., Liang, C., Ding, Y., Huang, D., Gou, H., Chen, D., Pan, Y., Kang, W., To, K. F., Yu, J. Tags: Open access, Gut Colon Source Type: research

Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a.
CONCLUSION: Overall, our data demonstrate the oncogenic role of circPIP5K1A-miR-1273a axis in regulation of colon cancer development, which provides a novel insights into colon cancer pathogenesis. PMID: 31558874 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - September 20, 2019 Category: Gastroenterology Authors: Zhang Q, Zhang C, Ma JX, Ren H, Sun Y, Xu JZ Tags: World J Gastroenterol Source Type: research

Downregulation of LncRNA-RP11-317J10.2 promotes cell proliferation and invasion and predicts poor prognosis in colorectal cancer.
CONCLUSIONS: This study reveals a crucial role for lncRNA-RP11-317J10.2 in CRC growth and invasion via upregulation of cyclin D1 expression and suggests that expression of this lncRNA may be a potential prognostic biomarker for CRC. PMID: 29073791 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - October 28, 2017 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Role of AXL in invasion and drug resistance of colon and breast cancer cells and its association with p53 alterations.
CONCLUSION: AXL is influenced by p53 status and could cause the emergence of aggressive clones after exposure to chemotherapy. These findings could have applications in cancer management. PMID: 28596680 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - May 21, 2017 Category: Gastroenterology Authors: Abdel-Rahman WM, Al-Khayyal NA, Nair VA, Aravind SR, Saber-Ayad M Tags: World J Gastroenterol Source Type: research

The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/{beta}-catenin signalling pathway
Conclusions We identified PRC1 as a novel Wnt target that functions in a positive feedback loop that reinforces Wnt signalling to promote early HCC recurrence.
Source: Gut - August 8, 2016 Category: Gastroenterology Authors: Chen, J., Rajasekaran, M., Xia, H., Zhang, X., Kong, S. N., Sekar, K., Seshachalam, V. P., Deivasigamani, A., Goh, B. K. P., Ooi, L. L., Hong, W., Hui, K. M. Tags: Open access, Colon cancer, Hepatic cancer Hepatology Source Type: research

Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer
Conclusions We developed a high-throughput deep sequencing approach for concomitant MSI and mutational analyses in FFPE specimens. We provided novel insights into clinically relevant alterations in MSI CRC and a rationale for targeting ERBB2/HER2 mutations in Lynch and Lynch-like CRC.
Source: Gut - July 7, 2016 Category: Gastroenterology Authors: Kloth, M., Ruesseler, V., Engel, C., Koenig, K., Peifer, M., Mariotti, E., Kuenstlinger, H., Florin, A., Rommerscheidt-Fuss, U., Koitzsch, U., Wodtke, C., Ueckeroth, F., Holzapfel, S., Aretz, S., Propping, P., Loeffler, M., Merkelbach-Bruse, S., Odenthal, Tags: Colon cancer Source Type: research

Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells.
CONCLUSION: ASNS may contribute to gastric cancer tumorigenesis and may represent a novel therapeutic target for prevention or intervention of gastric cancer. PMID: 27251594 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - June 3, 2016 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling
Conclusions Our study helps to unravel the mechanism by which BCL-3 is linked to poor prognosis in colorectal cancer; we suggest that targeting BCL-3 activity represents an exciting therapeutic opportunity potentially increasing the sensitivity of tumour cells to conventional therapy.
Source: Gut - June 2, 2016 Category: Gastroenterology Authors: Urban, B. C., Collard, T. J., Eagle, C. J., Southern, S. L., Greenhough, A., Hamdollah-Zadeh, M., Ghosh, A., Poulsom, R., Paraskeva, C., Silver, A., Williams, A. C. Tags: Open access, Colon cancer Source Type: research

Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development.
Conclusions TRIM3 functions as a tumour suppressor in CRC progression. This tumour-suppressive function is exerted partially through regulation of p53 protein. Therefore, this protein may represent a novel therapeutic target for prevention or intervention of CRC. PMID: 26691157 [PubMed - in process]
Source: Scandinavian Journal of Gastroenterology - February 14, 2016 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

AKT and JNK Signaling Pathways Increase the Metastatic Potential of Colorectal Cancer Cells by Altering Transgelin Expression
Conclusion This study demonstrates, for the first time, that activated AKT and JNK signaling pathways promote the overexpression of transgelin, which potentially contributes to CRC progression and metastasis.
Source: Digestive Diseases and Sciences - December 22, 2015 Category: Gastroenterology Source Type: research

Role of milk fat globule-epidermal growth factor 8 in colonic inflammation and carcinogenesis
Conclusions MFG-E8 promotes tumor growth regardless of the presence or absence of colonic inflammation, whereas colon tumor development is initiated by MFG-E8 under inflammatory conditions. These MFG-E8 functions may be dependent on integrin-mediated cellular signaling.
Source: Journal of Gastroenterology - January 18, 2015 Category: Gastroenterology Source Type: research

Osteopontin knockdown suppresses the growth and angiogenesis of colon cancer cells.
CONCLUSION: Knockdown of OPN gene expression suppresses colon cancer cell growth, adherence, invasion, and expression of angiogenic factors. PMID: 25132760 [PubMed - in process]
Source: World Journal of Gastroenterology - August 14, 2014 Category: Gastroenterology Authors: Wu XL, Lin KJ, Bai AP, Wang WX, Meng XK, Su XL, Hou MX, Dong PD, Zhang JJ, Wang ZY, Shi L Tags: World J Gastroenterol Source Type: research

Sa1959 Curcumin Induces Autophagic Survival of DCLK1+VE Colon Cancer Stem Cells (CSCs), While Co-Treatment With Curcumin and DCLK1-siRNA Eliminates CSCS: Role of Long and Short Isofoms of DCLK1
Source: Gastroenterology - May 1, 2014 Category: Gastroenterology Authors: Malaney R. O'Connell, Shubhashish Sarkar, Carla Kantara, Pomila Singh Source Type: research

Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy.
CONCLUSION: SeV/dF/FIR showed strong tumor growth suppression with no significant side effects in an animal xenograft model, thus SeV/dF/FIR is potentially applicable for future clinical cancer treatment. PMID: 24764668 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - April 21, 2014 Category: Gastroenterology Authors: Matsushita K, Shimada H, Ueda Y, Inoue M, Hasegawa M, Tomonaga T, Matsubara H, Nomura F Tags: World J Gastroenterol Source Type: research

Clinicopathological and biological significance of cripto overexpression in human colon cancer.
CONCLUSION: The results provide evidence that cripto siRNA could be an effective approach for the inhibition of cancer cell invasion and migration and thus has potential for use in devising novel preventive and therapeutic strategies for colon cancer metastasis. PMID: 24379580 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - December 14, 2013 Category: Gastroenterology Authors: Jiang PC, Zhu L, Fan Y, Zhao HL Tags: World J Gastroenterol Source Type: research

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