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Cancer: Thyroid Cancer

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Total 208 results found since Jan 2013.

Effects of RNA interference of CTHRC1 on proliferation and apoptosis of thyroid papillary cancer TCP-1 cells < em > in vitro < /em >
Nan Fang Yi Ke Da Xue Xue Bao. 2021 Apr 20;41(4):549-554. doi: 10.12122/j.issn.1673-4254.2021.04.10.ABSTRACTOBJECTIVE: To explore the role of CTHRC1 in regulating the proliferation and apoptosis of papillary thyroid cancer cells.OBJECTIVE: Papillary thyroid cancer TPC-1 cells were transfected with a small interfering RNA (siRNA) targeting CTHRC1, with the cells transfected with a scrambled sequence as the negative control. The changes in cell proliferation and apoptosis were assessed using cell counting kit-8 (CCK-8) and flow cytometry with AV/PI double staining, respectively. The expression of c-caspase-3, c-PARP1 and pho...
Source: Journal of Southern Medical University - May 8, 2021 Category: Universities & Medical Training Authors: Z Tang X Ding S Qin C Zhang Source Type: research

A-Kinase Interacting Protein 1 Knockdown Restores Chemosensitivity via Inactivating PI3K/AKT and β-Catenin Pathways in Anaplastic Thyroid Carcinoma
ConclusionAKIP1 knockdown decreases cell survival and invasion while promoting sensitivity to doxorubicin via inactivating PI3K/AKT and β-catenin pathways in ATC.
Source: Frontiers in Oncology - July 28, 2022 Category: Cancer & Oncology Source Type: research

STRA6 promotes thyroid carcinoma progression via activation of the ILK/AKT/mTOR axis in cells and female nude mice
CONCLUSIONS: Our study demonstrates the critical roles of STRA6 contributing to TC progression via the ILK/AKT/mTOR axis, which may provide a novel prognostic marker as well as a promising therapeutic target for aggressive TC.PMID:36592123 | DOI:10.1210/endocr/bqac215
Source: Endocrinology - January 2, 2023 Category: Endocrinology Authors: Weiman He Zhen Cheng Zijun Huo Bo Lin Xuejie Wang Yijia Sun Shuang Yu Siting Cao Junyu Xue Rengyun Liu Weiming Lv Yanbing Li Shubin Hong Haipeng Xiao Source Type: research

Targeting SHP2 reverses BRAF inhibitor tolerance in anaplastic thyroid carcinoma
CONCLUSION: The SHP2 inhibitor SHP099 can effectively reverse the drug resistance of dabrafenib through inhibiting the reactivated RAS signaling pathway in anaplastic thyroid cancer.The combination of dabrafenib with SHP2 inhibitor has shown significant tumor suppressive effects for dabrafenib-resistant cells and it may be a new therapeutic strategy with longer lasting therapeutic benefits.PMID:36786145 | DOI:10.2174/1871520623666230214093122
Source: Cancer Control - February 14, 2023 Category: Cancer & Oncology Authors: Tao Tang Jie Zhou Li-Xin Zhang Gang Yang Wei-Nan Li Jian-Jiao Zhu Yong-Fu Xiong Jing-Dong Li Source Type: research

TBK1 promotes thyroid cancer progress by activating the PI3K/Akt/mTOR signaling pathway
ConclusionMAZ silencing inhibited tumor progress of thyroid cancer cells, whereas this inhibitory effect was reversed by TBK1 overexpression.
Source: Immunity, Inflammation and Disease - March 14, 2023 Category: Allergy & Immunology Authors: Qiuli Jiang, Yingying Guan, Jingmei Zheng, Huadong Lu Tags: ORIGINAL ARTICLE Source Type: research

Laminin-5 gamma-2 (LAMC2) is highly expressed in anaplastic thyroid carcinoma and is associated with tumor progression, migration and invasion by modulating signaling of EGFR.
Conclusions:To our knowledge, this is the first report investigating the effect of LAMC2 on cell growth, cell cycle, migration, invasion and EGFR signaling in ATC cells, suggesting that LAMC2 may be a potential therapeutic target for treatment of ATC. PMID: 24170107 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 29, 2013 Category: Endocrinology Authors: Garg M, Kanojia D, Okamoto R, Jain S, Madan V, Chien W, Sampath A, Ding LW, Xuan M, Said JW, Doan NB, Liu LZ, Yang H, Gery S, Braunstein GD, Koeffler HP Tags: J Clin Endocrinol Metab Source Type: research

Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells
Conclusions: Targeting tumors that overproduce Sec62 with calmodulin antagonists in combination with targeted thapsigargin analogues may offer novel personalized therapeutic options.
Source: BMC Cancer - December 5, 2013 Category: Cancer & Oncology Authors: Maximilian LinxweilerStefan SchorrNico SchäubleMartin JungJohannes LinxweilerFrank LangerHans-Joachim SchäfersAdolfo CavaliéRichard ZimmermannMarkus Greiner Source Type: research

Effects of Silencing the RET/PTC1 Oncogene in Papillary Thyroid Carcinoma by siRNA-Squalene Nanoparticles With and Without Fusogenic Companion GALA-Cholesterol
Thyroid , Vol. 0, No. 0.
Source: Thyroid - January 10, 2014 Category: Endocrinology Tags: article Source Type: research

mTOR inhibition promotes TTF1-dependent redifferentiation and restores iodine uptake in thyroid carcinoma cell lines.
Conclusion: The present study has identified the TTF1-dependent molecular mechanisms through which inhibition of mTOR leads to redifferentiation of TC cells and subsequently to increased radioactive iodine uptake. PMID: 24712572 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - April 8, 2014 Category: Endocrinology Authors: Plantinga TS, Heinhuis B, Gerrits D, Netea MG, Joosten LA, Hermus AR, Oyen WJ, Schweppe RE, Haugen BR, Boerman OC, Smit JW, Netea-Maier RT Tags: J Clin Endocrinol Metab Source Type: research

The Roles of the Epithelial-Mesenchymal Transition Marker PRRX1 and MicroRNA 146b-5p in Papillary Thyroid Carcinoma Progression.
Abstract Thyroid carcinoma is the most common endocrine malignancy, and papillary thyroid carcinoma represents the most common thyroid cancer. Papillary thyroid carcinomas that invade locally or metastasize are associated with a poor prognosis. We found that, during epithelial-mesenchymal transition (EMT) induced by transforming growth factor-β1 (TGF-β1), papillary thyroid carcinoma cells acquired increased cancer stem cell-like features and the transcription factor paired-related homeobox protein 1 (PRX-1; alias PRRX1), a newly identified EMT inducer, was markedly up-regulated. miR-146b-5p was also transiently ...
Source: The American Journal of Pathology - June 16, 2014 Category: Pathology Authors: Hardin H, Guo Z, Shan W, Montemayor-Garcia C, Asioli S, Yu XM, Harrison AD, Chen H, Lloyd RV Tags: Am J Pathol Source Type: research