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Cancer: Lymphoma

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Total 468 results found since Jan 2013.

A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing
CONCLUSION: Our findings demonstrate that circHNRNPU_603aa is a promising diagnostic and therapeutic marker in both MM cells and BM niche.PMID:35260179 | DOI:10.1186/s13046-022-02276-7
Source: Clinical Lymphoma and Myeloma - March 9, 2022 Category: Cancer & Oncology Authors: Xiaozhu Tang Zhendong Deng Pinggang Ding Wanting Qiang Yue Lu Shengyao Gao Ye Hu Ye Yang Juan Du Chunyan Gu Source Type: research

Cancers, Vol. 14, Pages 531: CARD9 Forms an Alternative CBM Complex in Richter Syndrome
n Mellert Richter syndrome (RS) is defined as the transformation of chronic lymphocytic leukemia (CLL) into an aggressive lymphoma, mostly diffuse large B-cell lymphoma (DLBCL). Despite intensive therapy, patients with RS have an unfavorable clinical outcome. The detailed pathobiology of Richter transformation still needs to be elucidated. Here, we report high mRNA and protein levels of CARD9 in the RS cell line U-RT1. Co-immunoprecipitation revealed the assembly of a CBM complex using CARD9 instead of CARD11. CARD9 is known to be an activator of NF-кB signaling in myeloid cells. U-RT1 Western blot analys...
Source: Cancers - January 21, 2022 Category: Cancer & Oncology Authors: Julia Maier Andr é Lechel Ralf Marienfeld Thomas F. E. Barth Peter M öller Kevin Mellert Tags: Article Source Type: research

SAMHD1 Mutations and Expression in Mantle Cell Lymphoma Patients
SAMHD1 (sterile alpha motif domain and histidine-aspartate domain-containing protein 1) is a deoxynucleoside triphosphate triphosphohydrolase regulating innate immune and modulating DNA damage signaling. It plays an important role in the development of some tumors. SAMHD1 was also reported as a barrier to cytarabine, a common chemotherapy drug for mantle cell lymphoma (MCL), and as a biomarker of grim prognosis for acute myelocytic leukemia (AML) patients. However, SAMHD1 expression and function in MCL have not been well-defined. In the present study, we evaluated SAMHD1 expression by immunohistochemistry and its gene stru...
Source: Frontiers in Oncology - December 17, 2021 Category: Cancer & Oncology Source Type: research

HYPK coordinates degradation of polyneddylated proteins by autophagy
Autophagy. 2021 Nov 26:1-22. doi: 10.1080/15548627.2021.1997053. Online ahead of print.ABSTRACTSelective degradation of protein aggregates by macroautophagy/autophagy is an essential homeostatic process of safeguarding cells from the effects of proteotoxicity. Among the ubiquitin-like proteins, NEDD8 conjugation to misfolded proteins is prominent in stress-induced protein aggregates, albeit the function of neddylation in autophagy is unclear. Here, we report that polyneddylation functions as a post-translational modification for autophagic degradation of proteotoxic-stress induced protein aggregates. We also show that HYPK...
Source: Autophagy - November 27, 2021 Category: Cytology Authors: Debasish Kumar Ghosh Akash Ranjan Source Type: research

Clinical and biological impact of SAMHD1 expression in mantle cell lymphoma
AbstractSAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase (dNTPase) that restricts viral replication in infected cells and limits the sensitivity to cytarabine by hydrolysing its active metabolite, as recently shown in acute myeloid leukemia. Cytarabine is an essential component in the Nordic mantle cell lymphoma protocols (MCL2 and MCL3) for induction and high-dose chemotherapy treatment before autologous stem cell transplantation for younger patients with mantle cell lymphoma (MCL). We here investigated the expression of SAMHD1 in a population-based cohort of MCL (N = 150). SAMHD1 was highly variably expre...
Source: Virchows Archiv - November 4, 2021 Category: Pathology Source Type: research

Potential Protective Role of TRPM7 and Involvement of PKC/ERK Pathway in Blue Light–Induced Apoptosis in Retinal Pigment Epithelium Cells in Vitro
Purpose: Blue light triggers apoptosis of retinal pigment epithelium (RPE) cells and causes retinal damage. The aim of this study was to elucidate the protective role of transient receptor potential melastatin 7 (TRPM7) in photodamaged RPE cells. Methods: RPE cells were isolated from Sprague-Dawley (SD) rats and exposed to varying intensities of blue light (500–5000 lux) in vitro. Cell proliferation and metabolic activity were respectively assessed by bromodeoxyuridine (BrdU) incorporation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assays. Real-time polymerase chain reaction (RT...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2021 Category: Opthalmology Tags: Original Study Source Type: research

The balance between cell survival and death in the placenta: Do neurotrophins have a role?
Syst Biol Reprod Med. 2021 Oct 6:1-10. doi: 10.1080/19396368.2021.1980132. Online ahead of print.ABSTRACTNeurotrophins (NT) are a closely related family of growth factors, which regulate the nervous system's development, maintenance, and function. Although NTs have been well studied in neuronal cells, they are also expressed in the placenta. Despite their suggested role in regulating fetoplacental development, their precise functional significance in the placenta remains elusive. NT activate two different classes of receptors. These include the Trk, tropomyosin-related kinase family of high-affinity tropomyosin-related kin...
Source: Reproductive Biology - October 7, 2021 Category: Reproduction Medicine Authors: Prachi Pathare-Ingawale Preeti Chavan-Gautam Source Type: research