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Cancer: Lymphoma
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Total 468 results found since Jan 2013.
BCL11A Facilitates Cell Proliferation and Metastasis in Neuroblastoma via Regulating the PI3K/Akt Signaling Pathway
CONCLUSION: As a prognostic indicator of survival in NB patients, BCL11A might serve as a potential therapeutic target. BCL11A played a regulatory role in cell proliferation, invasion and migration in NB,which may be through the PI3K/AKT signaling pathway and induce EMT.PMID:35909289 | DOI:10.2174/1568009622666220728123748
Source: Current Cancer Drug Targets - August 1, 2022 Category: Cancer & Oncology Authors: Qianya Jin Yanmin Chen Shibei Du Dongqing Xu Juanqing Yue Lei Cai Xiaojun Yuan Source Type: research
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth
Biochem J. 2022 May 18:BCJ20210770. doi: 10.1042/BCJ20210770. Online ahead of print.ABSTRACTUridine-cytidine kinase like-1 (UCKL-1) is a largely uncharacterized protein with high sequence similarity to other uridine-cytidine kinases (UCKs). UCKs play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine to UMP and CMP, respectively. Only two human UCKs have been identified, UCK1 and UCK2. Previous studies have shown both enzymes phosphorylate uridine and cytidine using ATP as the phosphate donor. No studies have evaluated the kinase potential of UCKL-1. We cloned and pu...
Source: The Biochemical Journal - May 18, 2022 Category: Biochemistry Authors: Emily Matchett Elise C Ambrose Jacki Kornbluth Source Type: research
Psoralidin protects against cerebral hypoxia/reoxygenation injury: Role of GAS6/Axl signaling
Phytother Res. 2022 May 18. doi: 10.1002/ptr.7481. Online ahead of print.ABSTRACTPsoralidin (PSO) is a natural phenolic coumarin extracted from the seeds of Psoralea corylifolia L. Growing preclinical evidence indicates that PSO has anti-inflammatory, anti-vitiligo, anti-bacterial, and anti-viral effects. Growth arrest-specific gene 6 (GAS6) and its receptor, Axl, modulate cellular oxidative stress, apoptosis, survival, proliferation, migration, and mitogenesis. Notably, the neuroprotective role of the GAS6/Axl axis has been identified in previous studies. We hypothesize that PSO ameliorates cerebral hypoxia/reoxygenation ...
Source: Cell Research - May 18, 2022 Category: Cytology Authors: Wangrui Lei Songdi Wu Aizhen Zhao Zhen Wu Baoping Ding Wenwen Yang Chenxi Lu Xue Wu Xiyang Li Shaofei Zhang Ye Tian Yang Yang Source Type: research
Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth
Biochem J. 2022 May 18:BCJ20210770. doi: 10.1042/BCJ20210770. Online ahead of print.ABSTRACTUridine-cytidine kinase like-1 (UCKL-1) is a largely uncharacterized protein with high sequence similarity to other uridine-cytidine kinases (UCKs). UCKs play an important role in the pyrimidine salvage pathway, catalyzing the phosphorylation of uridine and cytidine to UMP and CMP, respectively. Only two human UCKs have been identified, UCK1 and UCK2. Previous studies have shown both enzymes phosphorylate uridine and cytidine using ATP as the phosphate donor. No studies have evaluated the kinase potential of UCKL-1. We cloned and pu...
Source: The Biochemical Journal - May 18, 2022 Category: Biochemistry Authors: Emily Matchett Elise C Ambrose Jacki Kornbluth Source Type: research
HIF activation enhances Fc γRIIb expression on mononuclear phagocytes impeding tumor targeting antibody immunotherapy
CONCLUSION: Our findings provide a detailed molecular and cellular basis for hypoxia driven resistance to antitumor mAb immunotherapy, unveiling a hitherto unexplored aspect of the TME. These findings provide a mechanistic rationale for the modulation of FcγRIIb expression or its blockade as a promising strategy to enhance approved and novel mAb immunotherapies.PMID:35392965 | DOI:10.1186/s13046-022-02294-5
Source: Cell Research - April 8, 2022 Category: Cytology Authors: Khiyam Hussain Rena Liu Rosanna C G Smith Kri T J M üller Mohammadmersad Ghorbani Sofia Macari Kirstie L S Cleary Robert J Oldham Russell B Foxall Sonya James Steven G Booth Tom Murray Lekh N Dahal Chantal E Hargreaves Robert S Kemp Jemma Longley James D Source Type: research
Surface-Functionalized Polymeric siRNA Nanoparticles for Tunable Targeting and Intracellular Delivery to Hematologic Cancer Cells
Biomacromolecules. 2022 Apr 1. doi: 10.1021/acs.biomac.1c01497. Online ahead of print.ABSTRACTTo date, the application of RNA therapeutics to hematologic malignancies has been challenging owing to the resistance of blood cancer cells against conventional transfection methods. Herein, triple-targeting moiety-functionalized polymeric small interfering RNA (siRNA) nanoparticles were systematically developed for efficient targeted delivery of RNA therapeutics to hematologic cancer cells. Polymeric siRNAs were synthesized using rolling circle transcription and were surface-functionalized with three types of targeting moietiesâ”...
Source: Biomacromolecules - April 1, 2022 Category: Biochemistry Authors: Eunji Kwak Taehyung Kim Kyungjik Yang Young Min Kim Hwa Seung Han Kyung Hoon Park Ki Young Choi Young Hoon Roh Source Type: research
A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing
CONCLUSION: Our findings demonstrate that circHNRNPU_603aa is a promising diagnostic and therapeutic marker in both MM cells and BM niche.PMID:35260179 | DOI:10.1186/s13046-022-02276-7
Source: Clinical Lymphoma and Myeloma - March 9, 2022 Category: Cancer & Oncology Authors: Xiaozhu Tang Zhendong Deng Pinggang Ding Wanting Qiang Yue Lu Shengyao Gao Ye Hu Ye Yang Juan Du Chunyan Gu Source Type: research
