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PCSK9 and cancer: Rethinking the link
Biomed Pharmacother. 2021 May 28;140:111758. doi: 10.1016/j.biopha.2021.111758. Online ahead of print.ABSTRACTBACKGROUND: Cancer is emerging as a major problem globally, as it accounts for the second cause of death despite medical advances. According to epidemiological and basic studies, cholesterol is involved in cancer progression and there are abnormalities in cholesterol metabolism of cancer cells including prostate, breast, and colorectal carcinomas. However, the importance of cholesterol in carcinogenesis and thereby the role of cholesterol homeostasis as a therapeutic target is still a debated area in cancer therapy...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 31, 2021 Category: Drugs & Pharmacology Authors: Khadijeh Mahboobnia Matteo Pirro Ettore Marini Francesco Grignani Evgeny E Bezsonov Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research

Thrombospondin 2/Toll-Like Receptor 4 Axis Contributes to HIF-1 α-Derived Glycolysis in Colorectal Cancer
ConclusionOur findings revealed that the THBS2/TLR4 axis contributes to HIF-1α derived glycolysis and eventually promotes CRC progress.
Source: Frontiers in Oncology - November 10, 2020 Category: Cancer & Oncology Source Type: research

The JAK/STAT Pathway in Skeletal Muscle Pathophysiology
Conclusion and Perspectives The IL-6/JAK/STAT signaling cascade plays a dominant role in skeletal muscle pathophysiology. IL-6 autocrine, paracrine, and endocrine functions assign to its downstream effectors pivotal importance in skeletal muscle-wasting-associated diseases and other multiple system diseases where muscle acts in communication with other organs. Targeting the components of the JAK/STAT pathway recently emerged as a strategic approach for the treatment of inflammatory diseases and human cancer. This review highlights the opposite outcomes on muscle biology caused by the amount of local and systemic release ...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Oligonucleotides —A Novel Promising Therapeutic Option for IBD
Conclusions In this review, we focused on recent and past approaches to test the therapeutic efficacy of oligonucleotide based therapies in IBD. The combining mechanistic mode of oligonucleotide based therapeutics is a targeted action on specific pro-inflammatory molecules, which are over activated in IBD patients and contribute significantly to disease pathogenesis. The proposed high selectivity of the agents is derived from its mode of action, that aims to specifically block certain inflammatory molecular patterns, without a general systemic effect on other molecular targets. It would be important for each oligonucleot...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

PGC1 β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression
Conclusions: PGC1β regulates breast cancer tumor growth and metastasis by SREBP1-mediated HKDC1 expression. This provides a novel therapeutic strategy through targeting the PGC1β/HKDC1 signaling pathway for breast cancer treatment. Introduction Breast cancer is a very common cancer with significant premature mortality in women. Around 12% of women in USA will have chance to be diagnosed with breast cancer during their lifetimes (1, 2). The development of breast cancer is regulated by many factors, and even as average survival rates have increased significantly as a result of many advanced treatments...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Hepatoma-Derived Growth Factor and DDX5 Promote Carcinogenesis and Progression of Endometrial Cancer by Activating β-Catenin
Conclusion: Our results provide novel evidence that HDGF interacts with DDX5 and promotes the progression of EC through the induction of β-catenin. Introduction Endometrial cancer (EC) comprises the most common malignancy involving the female genital tract and the fourth most common malignancy in women after breast, lung, and colorectal cancers (1). In 2012, approximately 320,000 new cases of EC were diagnosed worldwide and the incidence is increasing (2). Currently, endometrial carcinogenesis is thought to be a multi-step process involving the coordinated interaction of hormonal regulation, gene mutation, ad...
Source: Frontiers in Oncology - April 10, 2019 Category: Cancer & Oncology Source Type: research

Downregulation of LncRNA-RP11-317J10.2 promotes cell proliferation and invasion and predicts poor prognosis in colorectal cancer.
CONCLUSIONS: This study reveals a crucial role for lncRNA-RP11-317J10.2 in CRC growth and invasion via upregulation of cyclin D1 expression and suggests that expression of this lncRNA may be a potential prognostic biomarker for CRC. PMID: 29073791 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - October 28, 2017 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Effects of HMGA2 siRNA and doxorubicin dual delivery by chitosan nanoparticles on cytotoxicity and gene expression of HT‐29 colorectal cancer cell line
ConclusionIn conclusion, our results revealed that dual delivery of a key gene siRNA and appropriate anticancer drug have great impact on the treatment of colorectal cancer.
Source: Journal of Pharmacy and Pharmacology - June 27, 2016 Category: Drugs & Pharmacology Authors: Homayoon Siahmansouri, Mohammad Hossein Somi, Zohreh Babaloo, Behzad Baradaran, Farhad Jadidi‐Niaragh, Fatemeh Atyabi, Hamed Mohammadi, Majid Ahmadi, Mehdi Yousefi Tags: Research Paper Source Type: research

Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells.
CONCLUSION: ASNS may contribute to gastric cancer tumorigenesis and may represent a novel therapeutic target for prevention or intervention of gastric cancer. PMID: 27251594 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - June 3, 2016 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development.
Conclusions TRIM3 functions as a tumour suppressor in CRC progression. This tumour-suppressive function is exerted partially through regulation of p53 protein. Therefore, this protein may represent a novel therapeutic target for prevention or intervention of CRC. PMID: 26691157 [PubMed - in process]
Source: Scandinavian Journal of Gastroenterology - February 14, 2016 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Abstract 112: Synthesis and preclinical evaluation of radiolabeled alisertib as an investigational aurora kinase A PET tracer
Conclusions: Both [3H]alisertib and [11C]alisertib were obtained with good purity and yield. In vitro studies using [3H]alisertib indicate good correlation of cellular uptake with AURKA expression. [11C]alisertib is stable in vivo and HCT116 xenografted mice show a fair tumor uptake of [11C]alisertib. Citation Format: Joost Verbeek, Jeroen ACM Goos, Albert A. Geldof, Annemieke C. Hiemstra, Otto S. Hoekstra, Gerrit A. Meijer, Steven Stroud, Daniel Bradley, Remond JA Fijneman, Albert D. Windhorst. Synthesis and preclinical evaluation of radiolabeled alisertib as an investigational aurora kinase A PET tracer. [abstract]. In: ...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Verbeek, J., Goos, J. A., Geldof, A. A., Hiemstra, A. C., Hoekstra, O. S., Meijer, G. A., Stroud, S., Bradley, D., Fijneman, R. J., Windhorst, A. D. Tags: Cancer Chemistry Source Type: research