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Knockdown of SIX4 inhibits pancreatic cancer cells via apoptosis induction
AbstractSine oculis homeobox 4 (SIX4), a critical transcription factor modulating organ development, potentially participates in tumorigenesis through numerous pathways. Here, we investigated siRNA-mediated knockdown effects ofSIX4 on pancreatic cancer cells and underlying molecular mechanisms. The expression ofSIX4 in pancreatic cancer and adjacent tissues were investigated in clinical tissue samples and bioinformatically approved by gene expression omnibus (GEO) database. Appropriate siRNA transfected into PANC1 pancreatic cancer cells in order toSIX4 knockdown. The survival, migration, invasion, colony formation, mitoch...
Source: Medical Oncology - September 1, 2023 Category: Cancer & Oncology Source Type: research
Ruscogenin Alleviates Myocardial Ischemia via Myosin IIA-Dependent Mitochondrial Fusion and Fission Balance
In this study, we observed that RUS markedly reduced MI-induced myocardial injury, as evidenced by notable reductions in infarct size, improvement in biochemical markers, alleviation of cardiac pathology, amelioration of mitochondrial damage, and inhibition of myocardial apoptosis. Moreover, RUS notably suppressed oxygen-glucose deprivation (OGD)-triggered cell injury and apoptosis. Notably, RUS demonstrated a considerable decrease of the interaction between myosin IIA and F-actin, along with the restoration of mitochondrial fusion and fission balance. We further confirmed that the effects of RUS on MI were mediated by myo...
Source: The American Journal of Chinese Medicine - August 31, 2023 Category: Complementary Medicine Authors: Jin-Cheng Liu Qing-Fei Zhao Ling Zhang Bo-Yang Yu Fang Li Jun-Ping Kou Source Type: research
Acetyl-cinobufagin suppresses triple-negative breast cancer progression by inhibiting the STAT3 pathway
CONCLUSIONS: The findings of this study support the potential clinical use of acetyl-cinobufagin as a STAT3 inhibitor in TNBC adjuvant therapy.PMID:37651362 | DOI:10.18632/aging.204967
Source: Aging - August 31, 2023 Category: Biomedical Science Authors: Yufeng Qi Haodong Wu Tianru Zhu Zitian Liu Conghui Liu Congzhi Yan Zhixuan Wu Yiying Xu Ying Bai Lehe Yang Dezhi Cheng Xiaohua Zhang Haiyang Zhao Chengguang Zhao Xuanxuan Dai Source Type: research
Ruscogenin Alleviates Myocardial Ischemia via Myosin IIA-Dependent Mitochondrial Fusion and Fission Balance
In this study, we observed that RUS markedly reduced MI-induced myocardial injury, as evidenced by notable reductions in infarct size, improvement in biochemical markers, alleviation of cardiac pathology, amelioration of mitochondrial damage, and inhibition of myocardial apoptosis. Moreover, RUS notably suppressed oxygen-glucose deprivation (OGD)-triggered cell injury and apoptosis. Notably, RUS demonstrated a considerable decrease of the interaction between myosin IIA and F-actin, along with the restoration of mitochondrial fusion and fission balance. We further confirmed that the effects of RUS on MI were mediated by myo...
Source: The American Journal of Chinese Medicine - August 31, 2023 Category: Complementary Medicine Authors: Jin-Cheng Liu Qing-Fei Zhao Ling Zhang Bo-Yang Yu Fang Li Jun-Ping Kou Source Type: research
GSE241894 Comparison of biochemical pathways affected by treatment with 4-methylumbelliferone and siRNA mediated knock down reveals hyaluronan synthase type 2 as a key pharmacological target in liver fibrosis
Contributors : Noreen Halimani ; Mikhail Nesterchuk ; Alexandra A Tsitrina ; Marat Sabirov ; Irina N Andreichenko ; Nataliya O Dashenkova ; Alexey M Kulikov ; Timofei S Zatsepin ; Roman A Romanov ; Arsen S Mikaelyan ; Yuri V KotelevtsevSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHepatic fibrosis is a morbid pathology with unmet medical need. 4- methylumbelliferone (4-MU), an inhibitor of hyaluronan (HA) synthesis was shown to be safe in phase one clinical trials. To support drug development, it is essential to decipher 4-MU ’s pharmacological targets. Here, we compared the effec...
Source: GEO: Gene Expression Omnibus - August 31, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Role of < em > Dgat2 < /em > in Glucose Uptake and Fatty Acid Metabolism in C2C12 Skeletal Myotubes
J Microbiol Biotechnol. 2023 Aug 18;33(12):1-9. doi: 10.4014/jmb.2307.07018. Online ahead of print.ABSTRACTAcyl-coenzyme A (CoA):diacylglycerol acyltransferase 2 (DGAT2) catalyzes the last stage of triacylglycerol (TAG) synthesis, a process that forms ester bonds with diacylglycerols (DAG) and fatty acyl-CoA substrates. The enzymatic role of Dgat2 has been studied in various biological species. Still, the full description of how Dgat2 channels fatty acids in skeletal myocytes and the consequence thereof in glucose uptake have yet to be well established. Therefore, this study explored the mediating role of Dgat2 in glucose ...
Source: Journal of Microbiology and Biotechnology - August 30, 2023 Category: Biotechnology Authors: So Young Bu Source Type: research
Exosomes are involved in the intercellular transfer of rapamycin resistance in the breast cancer cells
CONCLUSION: We propose that DNA demethylation followed by increased expression of key genes may be one of the factors responsible for the progression and maintenance of the resistant cell phenotype that includes exosome-induced resistance.PMID:37645026 | PMC:PMC10460766 | DOI:10.34172/bi.2023.27490
Source: BioImpacts - August 30, 2023 Category: Research Authors: Yuri Yu Shchegolev Danila V Sorokin Alexander M Scherbakov Olga E Andreeva Diana I Salnikova Ekaterina I Mikhaevich Margarita V Gudkova Mikhail A Krasil'nikov Source Type: research
Role of < em > Dgat2 < /em > in Glucose Uptake and Fatty Acid Metabolism in C2C12 Skeletal Myotubes
J Microbiol Biotechnol. 2023 Aug 18;33(12):1-9. doi: 10.4014/jmb.2307.07018. Online ahead of print.ABSTRACTAcyl-coenzyme A (CoA):diacylglycerol acyltransferase 2 (DGAT2) catalyzes the last stage of triacylglycerol (TAG) synthesis, a process that forms ester bonds with diacylglycerols (DAG) and fatty acyl-CoA substrates. The enzymatic role of Dgat2 has been studied in various biological species. Still, the full description of how Dgat2 channels fatty acids in skeletal myocytes and the consequence thereof in glucose uptake have yet to be well established. Therefore, this study explored the mediating role of Dgat2 in glucose ...
Source: Journal of Microbiology and Biotechnology - August 30, 2023 Category: Biotechnology Authors: So Young Bu Source Type: research
Exosomes are involved in the intercellular transfer of rapamycin resistance in the breast cancer cells
CONCLUSION: We propose that DNA demethylation followed by increased expression of key genes may be one of the factors responsible for the progression and maintenance of the resistant cell phenotype that includes exosome-induced resistance.PMID:37645026 | PMC:PMC10460766 | DOI:10.34172/bi.2023.27490
Source: BioImpacts - August 30, 2023 Category: Research Authors: Yuri Yu Shchegolev Danila V Sorokin Alexander M Scherbakov Olga E Andreeva Diana I Salnikova Ekaterina I Mikhaevich Margarita V Gudkova Mikhail A Krasil'nikov Source Type: research
