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Total 41092 results found since Jan 2013.
Methylation of hypoxia-inducible factor 3 subunit alpha contributes to poor prognosis in lung adenocarcinoma
J Appl Genet. 2023 Sep 14. doi: 10.1007/s13353-023-00784-6. Online ahead of print.ABSTRACTHypoxia-inducible factor 3 subunit alpha (HIF3A) has been implicated in various types of cancers, while its precise role in the lung adenocarcinoma remains unclear. Our study aimed to investigate the roles of HIF3A in lung adenocarcinoma and its regulation by DNA methylation. We utilized bioinformatic tools, including UALCAN and KMPlot, to analyze the relationship between HIF3A expression, DNA methylation, and patient survival rate in lung adenocarcinoma. We also used siRNA-mediated knockdown of HIF3A and DNA-methyltransferase 1 (DNMT...
Source: J Appl Genet - September 14, 2023 Category: Genetics & Stem Cells Authors: Qin Shi Xiuxia Zheng Ying Hu Zhan Zhou Minshan Fang Xinhui Huang Source Type: research
GSE242834 Gene expression profiling and the effect of HDAC9 in cisplatin resistance of esophageal squamous cell carcinoma
Series Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensEsophageal cancer is one of the most serious health problems globally because of its high incidence and mortality rate. Cisplatin(CDDP) is the primary treatment but limited by the drug resistance. However, the mechanism of cisplatin resistance remains unclear. Herein, the CDDP-resistant cell line TE-1/CDDP was established to compared with TE-1, the expression profiles of circRNAs were compared between TE-1/CDDP and TE-1 using microarray analysis, Histone deacetylase 9(HDAC9) was identified significantly up-regulated. Using siRNA and conducting cell funct...
Source: GEO: Gene Expression Omnibus - September 14, 2023 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1
Microbiol Spectr. 2023 Sep 13:e0041723. doi: 10.1128/spectrum.00417-23. Online ahead of print.ABSTRACTHerpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon reactivation of the virus in immunocompromised patients, may trigger an innate immune response and induce damage of organs. In these conditions, HSV-1 may infect vascular endothelial cells, but little is known about the regulation of HSV-1 replication and possible defense mechanisms in these cells. The current study addresses the question of whet...
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Heena Doshi Katrin Spengler Amod Godbole Yi Sing Gee Jonathan Baell Jonathan S Oakhill Andreas Henke Regine Heller Source Type: research
Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia
Neurochem Res. 2023 Sep 13. doi: 10.1007/s11064-023-04022-7. Online ahead of print.ABSTRACTActivation of glial cells, astrocytes and microglia, has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Amyloid β (Aβ), which is aggregated and the aggregation is detected as characteristic pathology in AD brain, is known to be produced by neurons and to activate glial cells. Clearance of Aβ from the brain via active transport system is important to prevent the accumulation and aggregation. Low density lipoprotein receptor-related protein 2 (LRP2/megalin) is an Aβ transporter. However, expression ...
Source: Neurochemical Research - September 13, 2023 Category: Neuroscience Authors: Katsura Takano-Kawabe Kazuyuki Matoba Yoichi Nakamura Mitsuaki Moriyama Source Type: research
Lactobacillus-derived extracellular vesicles counteract A β42-induced abnormal transcriptional changes through the upregulation of MeCP2 and Sirt1 and improve Aβ pathology in Tg-APP/PS1 mice
In this study, we investigated whether Lactobacillus paracasei-derived extracellular vesicles (Lpc-EV) can directly act on neuronal cells to modify amyloid-beta (Aβ)-induced transcriptional changes and Aβ pathology in the brains of Tg-APP/PS1 mice. Lpc-EV treatment in HT22 neuronal cells counteracts Aβ-induced downregulation of Brain-derived neurotrophic factor (Bdnf), Neurotrophin 3 (Nt3), Nt4/5, and TrkB receptor, and reverses Aβ-induced altered expression of diverse nuclear factors, including the downregulation of Methyl-CpG binding protein 2 (Mecp2) and Sirtuin 1 (Sirt1). Systematic siRNA-mediated knockdown experim...
Source: Molecular Medicine - September 13, 2023 Category: Molecular Biology Authors: Hyejin Kwon Eun-Hwa Lee So-Young Park Jin-Young Park Jin-Hwan Hong Eun-Kyung Kim Tae-Seop Shin Yoon-Keun Kim Pyung-Lim Han Source Type: research
Autocrine motility factor receptor promotes the malignancy of glioblastoma by regulating cell migration and invasion
CONCLUSION: This study suggests that AMFR could be used as a therapeutic strategy for the clinical treatment of glioblastoma.PMID:37703903 | DOI:10.1080/01616412.2023.2257463
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Yao Zhang Xiuping Wang Guanghui Chen Yajing Lu Qiang Chen Source Type: research
Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia
Neurochem Res. 2023 Sep 13. doi: 10.1007/s11064-023-04022-7. Online ahead of print.ABSTRACTActivation of glial cells, astrocytes and microglia, has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Amyloid β (Aβ), which is aggregated and the aggregation is detected as characteristic pathology in AD brain, is known to be produced by neurons and to activate glial cells. Clearance of Aβ from the brain via active transport system is important to prevent the accumulation and aggregation. Low density lipoprotein receptor-related protein 2 (LRP2/megalin) is an Aβ transporter. However, expression ...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Katsura Takano-Kawabe Kazuyuki Matoba Yoichi Nakamura Mitsuaki Moriyama Source Type: research
Light-regulated RNA interference induced by p-hydroxyphenacyl-modified siRNA in mammalian cells
This study will open new doors for optochemical regulation of a variety of genes by pHP caging group in mammalian cell culture.PMID:37700699 | DOI:10.1080/15257770.2023.2258171
Source: Nucleosides, Nucleotides and Nucleic Acids - September 13, 2023 Category: Biochemistry Authors: Swati Arora Chengde Mao Source Type: research
Tumor targeted siRNA delivery by adenosine receptor-specific curdlan nanoparticles
In this study, to improve biocompatibility and enhance tumor-targeting efficacy of the curdlan derivative, we pegylated the adenosine functionalized amino curdlan derivative (denoted by pAVC polymer). We confirmed that the uptake of pAVC polymer carrying siRNA by tumor cells was adenosine receptor (AR)-dependent and was specifically inhibited by AMP but not by GMP. The pAVC polymers not only preserved the receptor recognition and exhibited significantly decreased cytotoxicity but also showed remarkable tumor targeting efficiency in vivo. The nanoparticles formulated from siRNA (against STAT3) and pAVC4 polymer, which bears...
Source: International Journal of Biological Macromolecules - September 13, 2023 Category: Biochemistry Authors: Qingming Bao Tsogzolmaa Ganbold Mingming Bao Hai Xiao Shuqin Han Huricha Baigude Source Type: research
