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Total 41092 results found since Jan 2013.
A Trial to Learn if Having ALN-PNP siRNA is Safe and Well Tolerated, and How it Works in Adult Participants With Nonalcoholic Fatty Liver Disease (NAFLD) and a Genetic Risk Factor
Conditions: Nonalcoholic Steatohepatitis; Genetic Risk Factor Interventions: Drug: ALN-PNP Dose Level 1; Drug: ALN-PNP Dose Level 2; Drug: ALN-PNP Dose Level 3; Drug: Matching Placebo Sponsor: Regeneron Pharmaceuticals Not yet recruiting
Source: ClinicalTrials.gov - September 6, 2023 Category: Research Source Type: clinical trials
Silencing of novel TtVtg6-like induced ovarian cell apoptosis in ancient chelicerate Tachypleus tridentatus
In this study, we have successfully elucidated the complete transcript sequence of TtVtg6-like from an ancient chelicerate Tachypleus tridentatus. The TtVtg6-like transcript encompassed a length of 4887 bp and encoded 1629 amino acids residues. Notably, TtVtg6-like was found to contain 25 exons. Furthermore, the molecular weight and isoelectric point of TtVtg6-like were determined to be 191.6 KDa and 6.73, respectively. Subsequent mRNA expression analysis demonstrated the specific expression of TtVtg6-like in ovary and yellow connective tissue. In addition, TtVtg6-like was located and distributed in both ovary and yellow c...
Source: Cell Research - September 6, 2023 Category: Cytology Authors: Kianann Tan Khor Waiho Karsoon Tan Ying Qiao Leong-Seng Lim Xin Yang Yulong Wen Peng Xu Ya Peng Xiaowan Ma Kit Yue Kwan Source Type: research
The Upregulation of miR-22 alleviates oxygen-glucose deprivation/reperfusion-induced injury by targeting Tiam1 in SH-SY5Y cells
In this study, we evaluated whether miR-22 participates in I/R-induced neuronal injury and the potential mechanism by using an oxygen-glucose deprivation/reperfusion (OGD/R) model in vitro. Our results showed that miR-22 was significantly down-regulated in SH-SY5Y cells suffering from OGD/R. Up-regulation of miR-22 by its specific mimic could protect SH-SY5Y cells against OGD/R-induced injury. The luciferase reporter assay demonstrated that T-cell lymphoma invasion and metastasis 1 (Tiam1) was a direct target of miR-22. MiR-22 mimic obviously inhibited Tiam1 expression in OGD/R-exposed SH-SY5Y cells. Tiam1 siRNA could atte...
Source: Acta Biochim Pol - September 6, 2023 Category: Biochemistry Authors: Jiansong Yin Yu Wan Jing Wang Mei Xue Source Type: research
irc_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis
CONCLUSION: Silencing circ_PWWP2A can inhibit the proliferation of lung fibroblasts induced by TGF-β through the miR-27b-3p/GATA3 axis, and reduce BLM-induced pulmonary fibrosis in rats, which may be a potential therapeutic target for IPF.PMID:37672715 | DOI:10.18388/abp.2020_6459
Source: Acta Biochim Pol - September 6, 2023 Category: Biochemistry Authors: LiQing Su Ying Nian TianJi Zhu Source Type: research
GSE221308 Xbp1 knockdown in CHO cells stably expressing Cdh13 (RNA-Seq)
Contributors : Shunbun Kita ; Keita FukuokaSeries Type : Expression profiling by high throughput sequencingOrganism : Cricetulus griseusRNA expressions of CHO cells stably expressing Cdh13 were compared between cells transfected with negative control siRNA and with Xbp1 siRNA for 48 hours.
Source: GEO: Gene Expression Omnibus - September 6, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Cricetulus griseus Source Type: research
Transcription Factor JunB Suppresses Hepatitis C Virus Replication
Kobe J Med Sci. 2023 Aug 31;69(3):E86-E95.ABSTRACTWe previously reported that hepatitis C virus (HCV) infection activates the reactive oxygen species (ROS)/c-Jun N-terminal kinase (JNK) signaling pathway. Activation of JNK contributes to the development of liver diseases, including metabolic disorders, steatosis, liver cirrhosis and hepatocellular carcinoma. JNK is known to have numerous target genes, including JunB, a member of activator protein-1 transcription factor family. However, the roles of JunB in the HCV life cycle and HCV-associated pathogenesis remain unclear. To clarify a physiological role of JunB in HCV infe...
Source: Kobe J Med Sci - September 4, 2023 Category: General Medicine Authors: Adi Ariffianto Lin Deng Saki Harada Yujiao Liang Chieko Matsui Takayuki Abe Ikuo Shoji Source Type: research
