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Total 41092 results found since Jan 2013.
Exosomes are involved in the intercellular transfer of rapamycin resistance in the breast cancer cells
CONCLUSION: We propose that DNA demethylation followed by increased expression of key genes may be one of the factors responsible for the progression and maintenance of the resistant cell phenotype that includes exosome-induced resistance.PMID:37645026 | PMC:PMC10460766 | DOI:10.34172/bi.2023.27490
Source: BioImpacts - August 30, 2023 Category: Research Authors: Yuri Yu Shchegolev Danila V Sorokin Alexander M Scherbakov Olga E Andreeva Diana I Salnikova Ekaterina I Mikhaevich Margarita V Gudkova Mikhail A Krasil'nikov Source Type: research
GSE236523 CD44 is required for coupling autophagy decline and aging in the vascular endothelium
Contributors : Lu Zhang ; Peichang YangSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe decline of endothelial autophagy is closely related to vascular senescence and the development of diseases; however, little is known about the molecular mechanism by which autophagy decline is associated with aging in vascular endothelial cells (VECs). Here we identify a crucial role for CD44, a multifunctional adhesion molecule that has been implicated as a cancer stem cell marker in several cancers, in controlling autophagy and aging in VECs. CD44 intercellular domain (CD44ICD) negatively regulates autophagy via a...
Source: GEO: Gene Expression Omnibus - August 30, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Long non-coding RNA TUG1 regulates smooth muscle cell differentiation via KLF4-Myocardin axis
Am J Physiol Cell Physiol. 2023 Aug 29. doi: 10.1152/ajpcell.00275.2023. Online ahead of print.ABSTRACTAbdominal Aortic Aneurysms (AAAs) are asymptomatic vascular diseases that have life-threatening outcomes. Smooth-muscle cell (SMC) dysfunction plays an important role in AAA development. The contribution of non-coding genome, specifically the role of long non-coding RNAs (lncRNAs) in SMC dysfunction is relatively unexplored. we investigated the role of lncRNA TUG1 in SMC dysfunction. To identify potential lncRNAs relevant to SMC functionality, lncRNA profiling was performed in angiotensin-II treated SMCs. AAA was induced ...
Source: American Journal of Physiology. Cell Physiology - August 29, 2023 Category: Cytology Authors: Ravi Abishek Bharadhwaj Regalla Kumarswamy Source Type: research
Effect of GRK4 on renal gastrin receptor regulation in hypertension
CONCLUSION: GRK4 participates in the development of hypertension by regulating the phosphorylation of renal CCKBR leading to impaired CCKBR function and water and sodium retention. Knockdown of GRK4 restored the function of CCKBR. The enhanced co-connection between GRK4 and CCKBR may be an important reason for the hyperphosphorylation of GRK4 and CCKBR involved in the pathogenesis of hypertension.PMID:37641972 | DOI:10.1080/10641963.2023.2245580
Source: Clinical and Experimental Hypertension - August 29, 2023 Category: Cardiology Authors: Xuewei Xia Yongchun Zeng Zhuxin Li Hao Luo Wei Wang Yanji He Bingjun Lu Jingwen Guo Ken Chen Xiang Xu Source Type: research
Examining SRP pathway function in mRNA localization to the endoplasmic reticulum
RNA. 2023 Aug 29:rna.079643.123. doi: 10.1261/rna.079643.123. Online ahead of print.ABSTRACTSignal recognition particle (SRP) pathway function in protein translocation across the endoplasmic reticulum (ER) is well-established; its role in RNA localization to the ER remains however unclear. In current models, mRNAs undergo translation- and SRP-dependent trafficking to the ER, with ER localization mediated via interactions between SRP-bound translating ribosomes and the ER-resident SRP receptor (SR), a heterodimeric complex comprising SRA, the SRP-binding alpha subunit, and SRB, an integral membrane ER protein. To study SRP ...
Source: RNA - August 29, 2023 Category: Genetics & Stem Cells Authors: Jessica Rae Child Alex C Hofler Qiang Chen Brenda H Yang JohnCarlo Kristofich Tianli Zheng Molly M Hannigan Andrew L Elles David W Reid Christopher V Nicchitta Source Type: research
Toll-interacting protein may affect doxorubicin resistance in hepatocellular carcinoma cell lines
CONCLUSIONS: Our results showed for the first time that silencing TOLLIP in hepatocellular carcinoma cells may help sensitize these cells to doxorubicin and increase the efficacy of chemotherapeutic regimens where doxorubicin is used.PMID:37644370 | DOI:10.1007/s11033-023-08737-2
Source: Mol Biol Cell - August 29, 2023 Category: Molecular Biology Authors: Ayse Banu Demir Elif Baris Umay Bengi Kaner Hani Alotaibi Nese Atabey Ahmet Koc Source Type: research
Examining SRP pathway function in mRNA localization to the endoplasmic reticulum
RNA. 2023 Aug 29:rna.079643.123. doi: 10.1261/rna.079643.123. Online ahead of print.ABSTRACTSignal recognition particle (SRP) pathway function in protein translocation across the endoplasmic reticulum (ER) is well-established; its role in RNA localization to the ER remains however unclear. In current models, mRNAs undergo translation- and SRP-dependent trafficking to the ER, with ER localization mediated via interactions between SRP-bound translating ribosomes and the ER-resident SRP receptor (SR), a heterodimeric complex comprising SRA, the SRP-binding alpha subunit, and SRB, an integral membrane ER protein. To study SRP ...
Source: RNA - August 29, 2023 Category: Genetics & Stem Cells Authors: Jessica Rae Child Alex C Hofler Qiang Chen Brenda H Yang JohnCarlo Kristofich Tianli Zheng Molly M Hannigan Andrew L Elles David W Reid Christopher V Nicchitta Source Type: research
Long non-coding RNA TUG1 regulates smooth muscle cell differentiation via KLF4-Myocardin axis
Am J Physiol Cell Physiol. 2023 Aug 29. doi: 10.1152/ajpcell.00275.2023. Online ahead of print.ABSTRACTAbdominal Aortic Aneurysms (AAAs) are asymptomatic vascular diseases that have life-threatening outcomes. Smooth-muscle cell (SMC) dysfunction plays an important role in AAA development. The contribution of non-coding genome, specifically the role of long non-coding RNAs (lncRNAs) in SMC dysfunction is relatively unexplored. we investigated the role of lncRNA TUG1 in SMC dysfunction. To identify potential lncRNAs relevant to SMC functionality, lncRNA profiling was performed in angiotensin-II treated SMCs. AAA was induced ...
Source: American Journal of Physiology. Cell Physiology - August 29, 2023 Category: Cytology Authors: Ravi Abishek Bharadhwaj Regalla Kumarswamy Source Type: research
Effect of GRK4 on renal gastrin receptor regulation in hypertension
CONCLUSION: GRK4 participates in the development of hypertension by regulating the phosphorylation of renal CCKBR leading to impaired CCKBR function and water and sodium retention. Knockdown of GRK4 restored the function of CCKBR. The enhanced co-connection between GRK4 and CCKBR may be an important reason for the hyperphosphorylation of GRK4 and CCKBR involved in the pathogenesis of hypertension.PMID:37641972 | DOI:10.1080/10641963.2023.2245580
Source: Clinical and Experimental Hypertension - August 29, 2023 Category: Cardiology Authors: Xuewei Xia Yongchun Zeng Zhuxin Li Hao Luo Wei Wang Yanji He Bingjun Lu Jingwen Guo Ken Chen Xiang Xu Source Type: research
Long non-coding RNA TUG1 regulates smooth muscle cell differentiation via KLF4-Myocardin axis
Am J Physiol Cell Physiol. 2023 Aug 29. doi: 10.1152/ajpcell.00275.2023. Online ahead of print.ABSTRACTAbdominal Aortic Aneurysms (AAAs) are asymptomatic vascular diseases that have life-threatening outcomes. Smooth-muscle cell (SMC) dysfunction plays an important role in AAA development. The contribution of non-coding genome, specifically the role of long non-coding RNAs (lncRNAs) in SMC dysfunction is relatively unexplored. we investigated the role of lncRNA TUG1 in SMC dysfunction. To identify potential lncRNAs relevant to SMC functionality, lncRNA profiling was performed in angiotensin-II treated SMCs. AAA was induced ...
Source: Am J Physiol Cell Ph... - August 29, 2023 Category: Cytology Authors: Ravi Abishek Bharadhwaj Regalla Kumarswamy Source Type: research
Thiol-epoxy 'click' chemistry: a focus on molecular attributes in the context of polymer chemistry
Chem Commun (Camb). 2023 Aug 29. doi: 10.1039/d3cc02555a. Online ahead of print.ABSTRACTBase-catalyzed ring-opening reaction of epoxides with the thiol nucleophiles is useful in the preparation and post-polymerization modification of synthetic polymers. Due to its many beneficial characteristics, this process is referred to as the thiol-epoxy 'click' reaction. In this article, our aim is to discuss the fundamental attributes of this process by tracing our own steps in the field. We initially address the aspects of efficiency, regio-selectivity, stoichiometry, and reaction conditions with the help of linear, hyperbranched, ...
Source: Chemical Communications - August 29, 2023 Category: Chemistry Authors: Anzar Khan Source Type: research
