irc_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis

CONCLUSION: Silencing circ_PWWP2A can inhibit the proliferation of lung fibroblasts induced by TGF-β through the miR-27b-3p/GATA3 axis, and reduce BLM-induced pulmonary fibrosis in rats, which may be a potential therapeutic target for IPF.PMID:37672715 | DOI:10.18388/abp.2020_6459

Source: Acta Biochim Pol - September 6, 2023 Category: Biochemistry Authors: LiQing Su Ying Nian TianJi Zhu Source Type: research