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Vaccination: Influenza Vaccine

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Total 6509 results found since Jan 2013.

Expression of a single siRNA against a conserved region of NP gene strongly inhibits in vitro replication of different Influenza A virus strains of avian and swine origin.
In conclusion, these findings reveal new siRNA sequences able to inhibit Influenza A virus replication and provide a basis for the development of siRNAs as prophylaxis and therapy for influenza infection both in humans and animals. PMID: 25986248 [PubMed - as supplied by publisher]
Source: Antiviral Research - May 16, 2015 Category: Virology Authors: Stoppani E, Bassi I, Dotti S, Lizier M, Ferrari M, Lucchini F Tags: Antiviral Res Source Type: research

Expression of a single siRNA against a conserved region of NP gene strongly inhibits in vitro replication of different Influenza A virus strains of avian and swine origin
In conclusion, these findings reveal new siRNA sequences able to inhibit Influenza A virus replication and provide a basis for the development of siRNAs as prophylaxis and therapy for influenza infection both in humans and animals.
Source: Antiviral Therapy - May 17, 2015 Category: Virology Source Type: research

Application of Behavioral Theories to Disaster and Emergency Health Preparedness: A Systematic Review
CONCLUSIONS Based on the articles archived and selected, behavioral theories and models are applied to disasters and emergencies preparedness more commonly in developed countries (USA and Europe). In Asia, where the annual number of disasters events and victims exceed those in other continents, only 3 studies applying behavioral theories and models to disasters and emergencies were identifies. This identified a need for additional research to target the use of behavioral change theories in the Asian countries that bear the brunt of disasters and their consequences. This does not, however, mean that these theories have not ...
Source: PLOS Currents Disasters - July 1, 2015 Category: Global & Universal Authors: Luche Tadesse Ejeta Source Type: research

CDC Reports Flu Widespread, Google Search Trends Alarming
According to new surveillance statistics released on Friday from the Centers for Disease Control and Prevention (CDC), forty-seven states in the U.S. are now reporting widespread influenza activity [1]. The virus, which first appeared in the Southeast, has reached epidemic levels. Forty-seven states have reported widespread geographic influenza activity (i.e. incidence of flu) for the week between December 30, 2012 and January 5, 2013, and twenty-four states and New York City have reported high influenza-like illness (ILI) activity (i.e. the proportion of outpatient visits to healthcare providers for influenza-like illne...
Source: Highlight HEALTH - January 15, 2013 Category: Medical Scientists Authors: Walter Jessen, Ph.D. Source Type: blogs

Routine childhood vaccination programme coverage, El Salvador, 2011-In search of timeliness.
Abstract While assessing immunization programmes, not only vaccination coverage is important, but also timely receipt of vaccines. We estimated both vaccination coverage and timeliness, as well as reasons for non-vaccination, and identified predictors of delayed or missed vaccination, for vaccines of the first two years of age, in El Salvador. We conducted a cluster survey among children aged 23-59 months. Caregivers were interviewed about the child immunization status and their attitudes towards immunization. Vaccination dates were obtained from children immunization cards at home or at health facilities. We refe...
Source: Vaccine - December 3, 2013 Category: Allergy & Immunology Authors: Suárez-Castaneda E, Pezzoli L, Elas M, Baltrons R, Crespin-Elías EO, Pleitez OA, de Campos MI, Danovaro-Holliday MC Tags: Vaccine Source Type: research

IJERPH, Vol. 15, Pages 1432: In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children Before the Administration of the First Booster
Conclusions: Immunomodulation considered on the example of titre of IgG antibody to pertussis can serve as a useful model of the assessment of development of acquired immunity after mandatory vaccinations.
Source: International Journal of Environmental Research and Public Health - July 6, 2018 Category: Environmental Health Authors: Anna Bednarek Anna Bodajko-Grochowska Barbara Hasiec Robert Klepacz Katarzyna Szczekala Danuta Zarzycka Andrzej Emeryk Tags: Article Source Type: research

Knockdown of FLT4, Nup98, and Nup205 cellular genes effectively suppresses the reproduction of influenza virus strain A/WSN/1933 (H1N1) in vitro
CONCLUSION: We identified a number of genes such as FLT4, Nup98, and Nup205, the decrease in the expression of which can effectively suppress viral reproduction. The original siRNA sequences were also obtained. These results are important for the creation of therapeutic and prophylactic agents, whose action is based on the RNA interference mechanism.PMID:35339191 | DOI:10.2174/1871526522666220325121403
Source: Infectious Disorders Drug Targets - March 27, 2022 Category: Infectious Diseases Authors: Evgeny Pashkov Ekaterina Korchevaya Evgeny Faizuloev Artem Rtishchev Bogdan Cherepovich Elizaveta Bystritskaya Alexander Sidorov Alexander Poddubikov Anatoly Bykov Yuliya Dronina Oxana Svitich Vitaliy Zverev Source Type: research

Fight Aging! Newsletter, January 29th 2018
In conclusion, the present study demonstrated that TIGIT is a prominent negative immune regulator involved in immunosenescence. This novel finding is highly significant, as targeting TIGIT might be an effective strategy to improve the immune response and decrease age-related comorbidities. Delivery of Extracellular Vesicles as a Potential Basis for Therapies https://www.fightaging.org/archives/2018/01/delivery-of-extracellular-vesicles-as-a-potential-basis-for-therapies/ Here I'll point out a readable open access review paper on the potential use of extracellular vesicles as a basis for therapy: harveste...
Source: Fight Aging! - January 28, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Immune-Modulation by the Human Respiratory Syncytial Virus: Focus on Dendritic Cells
This study is complemented by another report that found that hRSV infection induces significant expression of three miRNAs, namely hsa-miR-4448, hsa-miR-30a-5p, and hsa-miR-4634 in human DCs (104). Interestingly, this latter study also performed comparative analyses of miRNA profiles between DCs infected with hRSV and a related virus, namely the human metapneumovirus, and found that both viruses induced the expression of elevated levels of hsa-miR-4634. Elucidating the contribution of these miRNAs in DCs in response to hRSV remains to be determined. Dendritic Cell Phenotype and Migration Upon hRSV Infection in vivo Altho...
Source: Frontiers in Immunology - April 14, 2019 Category: Allergy & Immunology Source Type: research

Interleukin-24 inhibits influenza A virus replication in vitro through induction of toll-like receptor 3 dependent apoptosis
This study demonstrates that IL-24 reduces the titer of different influenza A virus subtypes independently of type I interferon in an apoptosis dependent manner. The anti-viral effect of IL-24 correlated with caspase-3 activation and could be blocked by a pan-caspase inhibitor and by small interfering RNA (siRNA) directed towards TLR3. Surprisingly, caspase-3 activation in influenza A virus/IL-24-stimulated cells correlated with the down-regulation of the B-cell lymphoma 2 (Bcl-2) family member myeloid cell leukemia 1 (Mcl-1). Correspondingly, knockdown of Mcl-1 by siRNA enhanced caspase activation in influenza A virus inf...
Source: Antiviral Therapy - September 14, 2015 Category: Virology Source Type: research