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Role of the tripartite motif (TRIM) family in female genital neoplasms
Pathol Res Pract. 2023 Sep 9;250:154811. doi: 10.1016/j.prp.2023.154811. Online ahead of print.ABSTRACTThe tripartite motif proteins (TRIMs) family represents a class of highly conservative proteins which play a large regulatory role in molecular processes. Recently, increasing evidence has demonstrated a role of TRIMs in female genital neoplasms. Our review thereby aimed to provide an overview of the biological involvement of TRIMs in female genital neoplasms, to provide a better understanding of its role in the development and progression of such diseases, and emphasize its potential as targeted cancer therapy. Overall, ...
Source: Pathology, Research and Practice - September 15, 2023 Category: Pathology Authors: Tianyu Liu Jian Chen Jinjie Wu Qiqiao Du Junxiu Liu Silu Tan Yuwen Pan Shuzhong Yao Source Type: research
Paraptosis: a non-classical paradigm of cell death for cancer therapy
Acta Pharmacol Sin. 2023 Sep 15. doi: 10.1038/s41401-023-01159-7. Online ahead of print.ABSTRACTDue to the sustained proliferative potential of cancer cells, inducing cell death is a potential strategy for cancer therapy. Paraptosis is a mode of cell death characterized by endoplasmic reticulum (ER) and/or mitochondrial swelling and cytoplasmic vacuolization, which is less investigated. Considerable evidence shows that paraptosis can be triggered by various chemical compounds, particularly in cancer cells, thus highlighting the potential application of this non-classical mode of cell death in cancer therapy. Despite these ...
Source: Acta Pharmacologica Sinica - September 15, 2023 Category: Drugs & Pharmacology Authors: Chun-Cao Xu Yi-Fan Lin Mu-Yang Huang Xiao-Lei Zhang Pei Wang Ming-Qing Huang Jin-Jian Lu Source Type: research
Design, Development and in vitro quantification of novel electrosprayed Everolimus-loaded Soluplus ®/Polyvinyl alcohol nanoparticles via stability-indicating HPLC method in cancer therapy
In conclusion, the novel developed HPLC system can be applied for the quantification of different chemotherapeutic agents and the novel electrosprayed hydrogel NP is a potential drug delivery system to increase solubility and bioavailability of RAD001 in cancer therapy.PMID:37714413 | DOI:10.1016/j.ejpb.2023.09.008
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 15, 2023 Category: Drugs & Pharmacology Authors: Lynn Louis Bor Shin Chee Marion McAfee Michael J D Nugent Source Type: research
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Int J Oncol. 2023 Nov;63(5):126. doi: 10.3892/ijo.2023.5574. Epub 2023 Sep 15.ABSTRACTCancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been ...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Weiqiong Zhang Ruiping Zhou Xin Liu Lin You Chang Chen Xiaoling Ye Jie Liu Youde Liang Source Type: research
Role of the tripartite motif (TRIM) family in female genital neoplasms
Pathol Res Pract. 2023 Sep 9;250:154811. doi: 10.1016/j.prp.2023.154811. Online ahead of print.ABSTRACTThe tripartite motif proteins (TRIMs) family represents a class of highly conservative proteins which play a large regulatory role in molecular processes. Recently, increasing evidence has demonstrated a role of TRIMs in female genital neoplasms. Our review thereby aimed to provide an overview of the biological involvement of TRIMs in female genital neoplasms, to provide a better understanding of its role in the development and progression of such diseases, and emphasize its potential as targeted cancer therapy. Overall, ...
Source: Pathology, Research and Practice - September 15, 2023 Category: Pathology Authors: Tianyu Liu Jian Chen Jinjie Wu Qiqiao Du Junxiu Liu Silu Tan Yuwen Pan Shuzhong Yao Source Type: research
An application of carbohydrate polymers-based surface-modified gold nanoparticles for improved target delivery to liver cancer therapy - A systemic review
This article provides an update on using carbohydrate-based GNPs in liver cancer treatment, imaging, and drug administration. Selective surface modification of several carbohydrate types and further biological uses of GNPs are focused on.PMID:37714232 | DOI:10.1016/j.ijbiomac.2023.126889
Source: International Journal of Biological Macromolecules - September 15, 2023 Category: Biochemistry Authors: Abdullah R Alzahrani Ibrahim Abdel Aziz Ibrahim Naiyer Shahzad Imran Shahid Ibrahim M Alanazi Alaa Hisham Falemban Mohd Fahami Nur Azlina Source Type: research
Natural products and mitochondrial allies in colorectal cancer therapy
Biomed Pharmacother. 2023 Sep 13;167:115473. doi: 10.1016/j.biopha.2023.115473. Online ahead of print.ABSTRACTColorectal cancer (CRC) is a globally prevalent malignancy with a high potential for metastasis. Existing cancer treatments have limitations, including drug resistance and adverse effects. Researchers are striving to develop effective therapies to address these challenges. Impressively, contemporary research has discovered that many natural products derived from foods, plants, insects, and marine invertebrates can suppress the progression, metastasis, and invasion of CRC. In this review, we conducted a comprehensiv...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 15, 2023 Category: Drugs & Pharmacology Authors: Feng Wei Qing Nian Maoyuan Zhao Yueqiang Wen Yi Yang Jundong Wang Zhelin He Xiaoyan Chen Xiang Yin Jian Wang Xiao Ma Yu Chen Peimin Feng Jinhao Zeng Source Type: research
Surface modification strategies in translocating nano-vesicles across different barriers and the role of bio-vesicles in improving anticancer therapy
J Control Release. 2023 Sep 13:S0168-3659(23)00603-X. doi: 10.1016/j.jconrel.2023.09.016. Online ahead of print.ABSTRACTNanovesicles and bio-vesicles (BVs) have emerged as promising tools to achieve targeted cancer therapy due to their ability to overcome many of the key challenges currently being faced with conventional chemotherapy. These challenges include the diverse and often complex pathophysiology involving the progression of cancer, as well as the various biological barriers that circumvent therapeutic molecules reaching their target site in optimum concentration. The scientific evidence suggests that surface-funct...
Source: Cancer Control - September 15, 2023 Category: Cancer & Oncology Authors: Pratiksha Tiwari Krishna Yadav Ravi Prakash Shukla Shalini Gautam Disha Marwaha Madhu Sharma Prabhat Ranjan Mishra Source Type: research
Key role of exosomes derived from M2 macrophages in maintaining cancer cell stemness (Review)
Int J Oncol. 2023 Nov;63(5):126. doi: 10.3892/ijo.2023.5574. Epub 2023 Sep 15.ABSTRACTCancer stem cells (CSCs) constitute a specific subset of cells found within tumors that are responsible for initiating, advancing and resisting traditional cancer treatments. M2 macrophages, also known as alternatively activated macrophages, contribute to the development and progression of cancer through their involvement in promoting angiogenesis, suppressing the immune system, supporting tumor growth and facilitating metastasis. Exosomes, tiny vesicles released by cells, play a crucial role in intercellular communications and have been ...
Source: International Journal of Oncology - September 15, 2023 Category: Cancer & Oncology Authors: Weiqiong Zhang Ruiping Zhou Xin Liu Lin You Chang Chen Xiaoling Ye Jie Liu Youde Liang Source Type: research
Paraptosis: a non-classical paradigm of cell death for cancer therapy
Acta Pharmacol Sin. 2023 Sep 15. doi: 10.1038/s41401-023-01159-7. Online ahead of print.ABSTRACTDue to the sustained proliferative potential of cancer cells, inducing cell death is a potential strategy for cancer therapy. Paraptosis is a mode of cell death characterized by endoplasmic reticulum (ER) and/or mitochondrial swelling and cytoplasmic vacuolization, which is less investigated. Considerable evidence shows that paraptosis can be triggered by various chemical compounds, particularly in cancer cells, thus highlighting the potential application of this non-classical mode of cell death in cancer therapy. Despite these ...
Source: Acta Pharmacologica Sinica - September 15, 2023 Category: Drugs & Pharmacology Authors: Chun-Cao Xu Yi-Fan Lin Mu-Yang Huang Xiao-Lei Zhang Pei Wang Ming-Qing Huang Jin-Jian Lu Source Type: research
Synthesis of Ag nanoparticles for selective dual detection of glutathione and dopamine using N, N-dimethyl-p-phenylenediamine mediated colorimetric probe
We report a simple and easy method to synthesize Ag nanoparticles (Ag NPs) and demonstrate its potential for the detection of glutathione (GSH) and dopamine (DA) via colorimetric assay. The Ag NPs were found to be monodispersed and spherical with a size of 5 ± 2 nm. The X-ray diffraction (XRD) and high resolution transmission electron microscopy (HR-TEM) investigations revealed the formation of crystalline Ag NPs. The colour of N, N-dimethyl-p-phenylenediamine colorimetric assay changed from dark pink to colourless when the concentration of GSH was increased from 1 to 40 μM. Notably, the suspension colour changed from da...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Akash Kumar Sharmiladevi Ramamoorthy Anandhakumar Sundaramurthy Source Type: research
Allosteric switch for electrochemical aptasensor toward heavy metals pollution of Lentinus edodes sensitized with porphyrinic metal-organic frameworks
We present an appropriate electrochemical aptasensor for Ag + assay based on biomimetic catalysis of porphyrin-encapsulated MOF (PorMOF) and allosteric switch of C-rich DNA. Thanks to the excellent biocompatibility, PorMOFs as nanozyme are used to design signal probes by loading duplex-like DNA scaffold. Owing to the specific recognition of Ag+ toward cytosine (C) base-rich DNA, PorMOF at the distal end was close to the underlying electrode via C-Ag+-C formation, leading to an enhanced current of catalytic hydroxylamine oxidation for signal generation. Using the positive correlation between current response and Ag+ level, ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Xiaowei Huang Chenyong Huang Lili Zhou Guangyue Hou Jinyuan Sun Xinai Zhang Xiaobo Zou Source Type: research
Synthesis of Ag nanoparticles for selective dual detection of glutathione and dopamine using N, N-dimethyl-p-phenylenediamine mediated colorimetric probe
We report a simple and easy method to synthesize Ag nanoparticles (Ag NPs) and demonstrate its potential for the detection of glutathione (GSH) and dopamine (DA) via colorimetric assay. The Ag NPs were found to be monodispersed and spherical with a size of 5 ± 2 nm. The X-ray diffraction (XRD) and high resolution transmission electron microscopy (HR-TEM) investigations revealed the formation of crystalline Ag NPs. The colour of N, N-dimethyl-p-phenylenediamine colorimetric assay changed from dark pink to colourless when the concentration of GSH was increased from 1 to 40 μM. Notably, the suspension colour changed from da...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Akash Kumar Sharmiladevi Ramamoorthy Anandhakumar Sundaramurthy Source Type: research
