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Sympathetic Neural Overdrive and Diminished Exercise Capacity in Reduced Ejection Fraction Heart Failure Related to Anthracycline- Based Chemotherapy
Am J Physiol Heart Circ Physiol. 2023 Sep 8. doi: 10.1152/ajpheart.00476.2023. Online ahead of print.ABSTRACTCardiotoxicity is the most worrying cardiovascular alteration in patients treated with chemotherapy. To improve the understanding regarding the cardiotoxicity, we studied whether: 1) patients with cardiac dysfunction related to anthracycline-based chemotherapy have augmented sympathetic nerve activity and decreased exercise capacity and 2) these responses are similar to those observed in patients with heart failure caused by other etiologies. Sixteen patients with heart failure with reduced ejection fraction related...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 8, 2023 Category: Physiology Authors: Amanda G Rodrigues Allan R K Sales Diego Faria Silvia M R Fonseca Marina M K Bond Camila P Jordao Francis R de Souza Cristina S Bittar Marilia H H Dos Santos Adriana O Sarmento Marcelo V Negrao Ludhmila A Hajjar Carlos E Negr ão Roberto Kalil Filho Source Type: research
Integrative analysis identifies AKAP8L as an immunological and prognostic biomarker of pan-cancer
Aging (Albany NY). 2023 Sep 7;15. doi: 10.18632/aging.205003. Online ahead of print.ABSTRACTA-kinase anchoring protein 8L (AKAP8L) belong to the A-kinase anchoring protein (AKAP) family. Recent studies have proved that AKAP8L is associated with the progression of various tumors. To establish a more complete understanding of the significance of AKAP8L across various types of cancers, we conducted a detailed analysis of multiple histological datasets, including the level of gene expression in pancancer, biological function, molecular characteristics, as well as the diagnostic and prognostic value of AKAP8L in pancancer. Furt...
Source: Aging - September 8, 2023 Category: Biomedical Science Authors: Libo Zhou Jinhong Mei Runfu Cao Xiaoqiang Liu Bin Fu Ming Ma Binbin Gong Lianmin Luo Yifu Liu Qiqi Zhu Xuan Meng Source Type: research
Sympathetic Neural Overdrive and Diminished Exercise Capacity in Reduced Ejection Fraction Heart Failure Related to Anthracycline- Based Chemotherapy
Am J Physiol Heart Circ Physiol. 2023 Sep 8. doi: 10.1152/ajpheart.00476.2023. Online ahead of print.ABSTRACTCardiotoxicity is the most worrying cardiovascular alteration in patients treated with chemotherapy. To improve the understanding regarding the cardiotoxicity, we studied whether: 1) patients with cardiac dysfunction related to anthracycline-based chemotherapy have augmented sympathetic nerve activity and decreased exercise capacity and 2) these responses are similar to those observed in patients with heart failure caused by other etiologies. Sixteen patients with heart failure with reduced ejection fraction related...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 8, 2023 Category: Physiology Authors: Amanda G Rodrigues Allan R K Sales Diego Faria Silvia M R Fonseca Marina M K Bond Camila P Jordao Francis R de Souza Cristina S Bittar Marilia H H Dos Santos Adriana O Sarmento Marcelo V Negrao Ludhmila A Hajjar Carlos E Negr ão Roberto Kalil Filho Source Type: research
A cocktail therapeutic strategy based on clofarabine-containing aptamer-PROTAC for enhanced cancer therapy
Chem Commun (Camb). 2023 Sep 8. doi: 10.1039/d3cc02904b. Online ahead of print.ABSTRACTBy introducing a therapeutic nucleoside analogue tail to the parent Aptamer-PROTACs, a PROTAC-cocktail system (ApTCs-3X) was designed and evaluated. ApTCs-3X exhibited improved nuclease resistance and efficiently degraded target protein with subcellular localization preference. This cocktail therapy results in enhanced therapeutic outcomes, making it suitable for advancing PROTAC in combination therapy.PMID:37681438 | DOI:10.1039/d3cc02904b
Source: Chemical Communications - September 8, 2023 Category: Chemistry Authors: Zhenzhen Chen Mohan Chen Ran Liu Huanhuan Fan Jingjing Zhang Source Type: research
Sympathetic Neural Overdrive and Diminished Exercise Capacity in Reduced Ejection Fraction Heart Failure Related to Anthracycline- Based Chemotherapy
Am J Physiol Heart Circ Physiol. 2023 Sep 8. doi: 10.1152/ajpheart.00476.2023. Online ahead of print.ABSTRACTCardiotoxicity is the most worrying cardiovascular alteration in patients treated with chemotherapy. To improve the understanding regarding the cardiotoxicity, we studied whether: 1) patients with cardiac dysfunction related to anthracycline-based chemotherapy have augmented sympathetic nerve activity and decreased exercise capacity and 2) these responses are similar to those observed in patients with heart failure caused by other etiologies. Sixteen patients with heart failure with reduced ejection fraction related...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 8, 2023 Category: Physiology Authors: Amanda G Rodrigues Allan R K Sales Diego Faria Silvia M R Fonseca Marina M K Bond Camila P Jordao Francis R de Souza Cristina S Bittar Marilia H H Dos Santos Adriana O Sarmento Marcelo V Negrao Ludhmila A Hajjar Carlos E Negr ão Roberto Kalil Filho Source Type: research
Impact of a mental training program for pediatric cancer patients after allogeneic hematopoietic stem cell transplantation or high-dose chemotherapy - Results of a randomized controlled trial
Palliat Support Care. 2023 Sep 8:1-8. doi: 10.1017/S1478951523000986. Online ahead of print.ABSTRACTOBJECTIVES: Hematopoietic stem cell transplantation (HSCT) or intensive chemotherapy for the treatment of malignant diseases is a highly distressing experience. The affected person's resilience is crucial to coping with this challenging experience. Experience with resilience-enhancing interventions in children and young adults during cancer therapy is scarce. The major objective of this work was developing and evaluating an effective psycho-oncological mental training that complements the standard psychosocial care.METHODS: ...
Source: Palliative and Supportive Care - September 8, 2023 Category: Palliative Care Authors: Michaela D öring Johanna Xemaire Dustin Werle Stefanie Thiel Veronika Schneider Sebastian Michaelis Manuel Schl össer Peter Lang Jennifer Svaldi Karin Melanie Cabanillas Stanchi Source Type: research
Sympathetic Neural Overdrive and Diminished Exercise Capacity in Reduced Ejection Fraction Heart Failure Related to Anthracycline- Based Chemotherapy
Am J Physiol Heart Circ Physiol. 2023 Sep 8. doi: 10.1152/ajpheart.00476.2023. Online ahead of print.ABSTRACTCardiotoxicity is the most worrying cardiovascular alteration in patients treated with chemotherapy. To improve the understanding regarding the cardiotoxicity, we studied whether: 1) patients with cardiac dysfunction related to anthracycline-based chemotherapy have augmented sympathetic nerve activity and decreased exercise capacity and 2) these responses are similar to those observed in patients with heart failure caused by other etiologies. Sixteen patients with heart failure with reduced ejection fraction related...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 8, 2023 Category: Physiology Authors: Amanda G Rodrigues Allan R K Sales Diego Faria Silvia M R Fonseca Marina M K Bond Camila P Jordao Francis R de Souza Cristina S Bittar Marilia H H Dos Santos Adriana O Sarmento Marcelo V Negrao Ludhmila A Hajjar Carlos E Negr ão Roberto Kalil Filho Source Type: research
Novel design of dual-action Pt(IV) anticancer pro-drugs based on cisplatin and derivatives of the Tyrosine Kinase Inhibitors imatinib and nilotinib
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Darren Fergal Beirne, Barbara Farkas, Chiara Donati, Valentina Gandin, Isabel Rozas, Trinidad Velasco-Torrijos, Diego Montagner Tyrosine Kinases (TKs) are emerging as important targets in cancer therapy and some of their inhibitors TKi (i.e. Imatinib and Nilotinib) are FDA approved drugs that are used as selective... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - September 7, 2023 Category: Chemistry Authors: Darren Fergal Beirne Source Type: research
The Relationship Between Taste and Smell Alterations and Quality of Life Among Women With Breast Cancer Receiving Chemotherapy
Oncol Nurs Forum. 2023 Jun 15;50(4):499-508. doi: 10.1188/23.ONF.499-508.ABSTRACTOBJECTIVES: To understand taste and smell alterations (TSAs) and their relationship with quality of life among women with breast cancer receiving chemotherapy.SAMPLE & SETTING: A descriptive correlational study was conducted with 121 women with breast cancer receiving chemotherapy, and data were collected through an online survey.METHODS & VARIABLES: The Taste and Smell Survey was used to measure TSAs, and the Functional Assessment of Cancer Therapy-Breast was used to measure quality of life.RESULTS: More than half of the participants ...
Source: Oncology Nursing Forum - September 7, 2023 Category: Nursing Authors: Hae Jeong An Sook Jung Kang Source Type: research
Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics
We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplas...
Source: Angewandte Chemie - September 7, 2023 Category: Chemistry Authors: Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Chunhai Fan Yaakov Nahmias Itamar Willner Source Type: research
GLUT5: structure, functions, diseases and potential applications
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023158. Online ahead of print.ABSTRACTGlucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has been well understood to play a significant role in the pathogenesis of human digestive diseases. Recently, the role of GL...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aqian Song Yuanpeng Mao Hongshan Wei Source Type: research
The Relationship Between Taste and Smell Alterations and Quality of Life Among Women With Breast Cancer Receiving Chemotherapy
Oncol Nurs Forum. 2023 Jun 15;50(4):499-508. doi: 10.1188/23.ONF.499-508.ABSTRACTOBJECTIVES: To understand taste and smell alterations (TSAs) and their relationship with quality of life among women with breast cancer receiving chemotherapy.SAMPLE & SETTING: A descriptive correlational study was conducted with 121 women with breast cancer receiving chemotherapy, and data were collected through an online survey.METHODS & VARIABLES: The Taste and Smell Survey was used to measure TSAs, and the Functional Assessment of Cancer Therapy-Breast was used to measure quality of life.RESULTS: More than half of the participants ...
Source: Oncology Nursing Forum - September 7, 2023 Category: Nursing Authors: Hae Jeong An Sook Jung Kang Source Type: research
GLUT5: structure, functions, diseases and potential applications
Acta Biochim Biophys Sin (Shanghai). 2023 Sep 7. doi: 10.3724/abbs.2023158. Online ahead of print.ABSTRACTGlucose transporter 5 (GLUT5) is a membrane transporter that specifically transports fructose and plays a key role in dietary fructose uptake and metabolism. In recent years, a high fructose diet has occupied an important position in the daily intake of human beings, resulting in a significant increase in the incidence of obesity and metabolic diseases worldwide. Over the past few decades, GLUT5 has been well understood to play a significant role in the pathogenesis of human digestive diseases. Recently, the role of GL...
Source: Acta Biochimica et Biophysica Sinica - September 7, 2023 Category: Biochemistry Authors: Aqian Song Yuanpeng Mao Hongshan Wei Source Type: research
