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Allosteric switch for electrochemical aptasensor toward heavy metals pollution of Lentinus edodes sensitized with porphyrinic metal-organic frameworks
We present an appropriate electrochemical aptasensor for Ag + assay based on biomimetic catalysis of porphyrin-encapsulated MOF (PorMOF) and allosteric switch of C-rich DNA. Thanks to the excellent biocompatibility, PorMOFs as nanozyme are used to design signal probes by loading duplex-like DNA scaffold. Owing to the specific recognition of Ag+ toward cytosine (C) base-rich DNA, PorMOF at the distal end was close to the underlying electrode via C-Ag+-C formation, leading to an enhanced current of catalytic hydroxylamine oxidation for signal generation. Using the positive correlation between current response and Ag+ level, ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Xiaowei Huang Chenyong Huang Lili Zhou Guangyue Hou Jinyuan Sun Xinai Zhang Xiaobo Zou Source Type: research
Synthesis of Ag nanoparticles for selective dual detection of glutathione and dopamine using N, N-dimethyl-p-phenylenediamine mediated colorimetric probe
We report a simple and easy method to synthesize Ag nanoparticles (Ag NPs) and demonstrate its potential for the detection of glutathione (GSH) and dopamine (DA) via colorimetric assay. The Ag NPs were found to be monodispersed and spherical with a size of 5 ± 2 nm. The X-ray diffraction (XRD) and high resolution transmission electron microscopy (HR-TEM) investigations revealed the formation of crystalline Ag NPs. The colour of N, N-dimethyl-p-phenylenediamine colorimetric assay changed from dark pink to colourless when the concentration of GSH was increased from 1 to 40 μM. Notably, the suspension colour changed from da...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Akash Kumar Sharmiladevi Ramamoorthy Anandhakumar Sundaramurthy Source Type: research
Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects
Eur J Med Res. 2023 Sep 14;28(1):345. doi: 10.1186/s40001-023-01275-4.ABSTRACTCancer poses a significant global health challenge, with predictions of increasing prevalence in the coming years due to limited prevention, late diagnosis, and inadequate success with current therapies. In addition, the high cost of new anti-cancer drugs creates barriers in meeting the medical needs of cancer patients, especially in developing countries. The lengthy and costly process of developing novel drugs further hinders drug discovery and clinical implementation. Therefore, there has been a growing interest in repurposing approved drugs fo...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Roohi Mohi-Ud-Din Apporva Chawla Pooja Sharma Prince Ahad Mir Faheem Hyder Potoo Željko Reiner Ivan Reiner Dilek Arslan Ate şşahin Javad Sharifi-Rad Reyaz Hassan Mir Daniela Calina Source Type: research
Synthesis of Ag nanoparticles for selective dual detection of glutathione and dopamine using N, N-dimethyl-p-phenylenediamine mediated colorimetric probe
We report a simple and easy method to synthesize Ag nanoparticles (Ag NPs) and demonstrate its potential for the detection of glutathione (GSH) and dopamine (DA) via colorimetric assay. The Ag NPs were found to be monodispersed and spherical with a size of 5 ± 2 nm. The X-ray diffraction (XRD) and high resolution transmission electron microscopy (HR-TEM) investigations revealed the formation of crystalline Ag NPs. The colour of N, N-dimethyl-p-phenylenediamine colorimetric assay changed from dark pink to colourless when the concentration of GSH was increased from 1 to 40 μM. Notably, the suspension colour changed from da...
Source: Chemosphere - September 14, 2023 Category: Chemistry Authors: Akash Kumar Sharmiladevi Ramamoorthy Anandhakumar Sundaramurthy Source Type: research
In situ formation of alginic acid-gold nanohybrids for application in cancer photothermal therapy
This article is protected by copyright. All rights reserved.PMID:37706621 | DOI:10.1002/biot.202300019
Source: Biotechnology Journal - September 14, 2023 Category: Biotechnology Authors: Andr é Q Figueiredo Carolina F Rodrigues Natanael Fernandes Il ídio J Correia Andr é F Moreira Source Type: research
The emerging role of the gut microbiome in cancer cell plasticity and therapeutic resistance
Cancer Metastasis Rev. 2023 Sep 14. doi: 10.1007/s10555-023-10138-7. Online ahead of print.ABSTRACTResistance to therapeutic agents is one of the major challenges in cancer therapy. Generally, the focus is given to the genetic driver, especially the genetic mutation behind the therapeutic resistance. However, non-mutational mechanisms, such as epigenetic modifications, and TME alteration, which is mainly driven by cancer cell plasticity, are also involved in therapeutic resistance. The concept of plasticity mainly relies on the conversion of non-cancer stem cells (CSCs) to CSCs or epithelial-to-mesenchymal transition via d...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: Priya Mondal Syed Musthapa Meeran Source Type: research
Combined targeting of NAD biosynthesis and the NAD-dependent transcription factor C-terminal Binding Protein as a promising novel therapy for pancreatic cancer
Cancer Res Commun. 2023 Sep 13. doi: 10.1158/2767-9764.CRC-22-0521. Online ahead of print.ABSTRACTCancer therapies targeting metabolic derangements unique to cancer cells are emerging as a key strategy to address refractory solid tumors such as pancreatic ductal adenocarcinomas (PDAC) that exhibit resistance to extreme nutrient deprivation in the tumor microenvironment. Nicotinamide adenine dinucleotide (NAD) participates in multiple metabolic pathways and Nicotinamide phosphoribosyl transferase (NAMPT) is one of the key intracellular enzymes that facilitate the synthesis of NAD. C-terminal Binding Proteins 1 and 2 (CtBP) ...
Source: Cell Research - September 14, 2023 Category: Cytology Authors: M Michael Dcona Kranthi Kumar Chougoni Diana T Dcona Jacqueline L West Sahib J Singh Keith C Ellis Steven R Grossman Source Type: research
Allosteric switch for electrochemical aptasensor toward heavy metals pollution of Lentinus edodes sensitized with porphyrinic metal-organic frameworks
We present an appropriate electrochemical aptasensor for Ag + assay based on biomimetic catalysis of porphyrin-encapsulated MOF (PorMOF) and allosteric switch of C-rich DNA. Thanks to the excellent biocompatibility, PorMOFs as nanozyme are used to design signal probes by loading duplex-like DNA scaffold. Owing to the specific recognition of Ag+ toward cytosine (C) base-rich DNA, PorMOF at the distal end was close to the underlying electrode via C-Ag+-C formation, leading to an enhanced current of catalytic hydroxylamine oxidation for signal generation. Using the positive correlation between current response and Ag+ level, ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Xiaowei Huang Chenyong Huang Lili Zhou Guangyue Hou Jinyuan Sun Xinai Zhang Xiaobo Zou Source Type: research
In situ formation of alginic acid-gold nanohybrids for application in cancer photothermal therapy
This article is protected by copyright. All rights reserved.PMID:37706621 | DOI:10.1002/biot.202300019
Source: Biotechnology Journal - September 14, 2023 Category: Biotechnology Authors: Andr é Q Figueiredo Carolina F Rodrigues Natanael Fernandes Il ídio J Correia Andr é F Moreira Source Type: research
Allosteric switch for electrochemical aptasensor toward heavy metals pollution of Lentinus edodes sensitized with porphyrinic metal-organic frameworks
We present an appropriate electrochemical aptasensor for Ag + assay based on biomimetic catalysis of porphyrin-encapsulated MOF (PorMOF) and allosteric switch of C-rich DNA. Thanks to the excellent biocompatibility, PorMOFs as nanozyme are used to design signal probes by loading duplex-like DNA scaffold. Owing to the specific recognition of Ag+ toward cytosine (C) base-rich DNA, PorMOF at the distal end was close to the underlying electrode via C-Ag+-C formation, leading to an enhanced current of catalytic hydroxylamine oxidation for signal generation. Using the positive correlation between current response and Ag+ level, ...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Xiaowei Huang Chenyong Huang Lili Zhou Guangyue Hou Jinyuan Sun Xinai Zhang Xiaobo Zou Source Type: research
In situ formation of alginic acid-gold nanohybrids for application in cancer photothermal therapy
This article is protected by copyright. All rights reserved.PMID:37706621 | DOI:10.1002/biot.202300019
Source: Biotechnology Journal - September 14, 2023 Category: Biotechnology Authors: Andr é Q Figueiredo Carolina F Rodrigues Natanael Fernandes Il ídio J Correia Andr é F Moreira Source Type: research
Alkaloids as Additional Weapons in the Fight against Breast Cancer: A review
This study also includes an overview of synthesized analogues and pharmacological characteristics that will be beneficial to scientists working on alkaloids for medicinal purposes. In a recent survey of the literature, alkaloids are an important component of plant-derived antitumor medicines that hold great potential for the future development of cancer therapy and preventive therapies. We have also discussed structural analysis relationship (SAR) studies. Moreover, it covers clinical trial medications and FDA-approved medicines from the last five years that will be useful in further research.PMID:37702171 | DOI:10.2174/09...
Source: Current Medicinal Chemistry - September 13, 2023 Category: Chemistry Authors: None Chahat Keshav Taruneshwar Jha Rohit Bhatia Pooja A Chawla Source Type: research
Peroxisome proliferator-activated receptors as therapeutic target for cancer
J Cell Mol Med. 2023 Sep 12. doi: 10.1111/jcmm.17931. Online ahead of print.ABSTRACTPeroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the nuclear receptor family. There are three subtypes of PPARs, including PPAR-α, PPAR-β/δ and PPAR-γ. They are expressed in different tissues and act by regulating the expression of target genes in the form of binding to ligands. Various subtypes of PPAR have been shown to have significant roles in a wide range of biological processes including lipid metabolism, body energy homeostasis, cell proliferation and differentiation, bone formation, tiss...
Source: J Cell Mol Med - September 13, 2023 Category: Molecular Biology Authors: Yuqing Wang Feifei Lei Yiyun Lin Yuru Han Lei Yang Huabing Tan Source Type: research
