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Total 135484 results found since Jan 2013.
Dual RNase activity of IRE1 as a target for anticancer therapies
J Cell Commun Signal. 2023 Sep 18. doi: 10.1007/s12079-023-00784-5. Online ahead of print.ABSTRACTThe unfolded protein response (UPR) is a cellular mechanism that protects cells during stress conditions in which there is an accumulation of misfolded proteins in the endoplasmic reticulum (ER). UPR activates three signaling pathways that function to alleviate stress conditions and promote cellular homeostasis and cell survival. During unmitigated stress conditions, however, UPR activation signaling changes to promote cell death through apoptosis. Interestingly, cancer cells take advantage of this pathway to facilitate surviv...
Source: Journal of Cell Communication and Signaling - September 18, 2023 Category: Molecular Biology Authors: Sylwia Bartoszewska Jakub S ławski James F Collawn Rafa ł Bartoszewski Source Type: research
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Enantiomerization and enantioselective bioaccumulation of diclofop-methyl in tubifex worms
In this study, the hydrolysis of diclofop-methyl (DM) in aqueous system and the bioaccumulation of its main metabolite, Diclofop (DA), in the tubifex worms were investigated using enantioselective high-performance liquid chromatography. With the addition of tubifex, rapid hydrolysis was observed for DM. It is revealed that the hydrolysis of DM in the water and the accumulation of DA in the worms were both enantioselective. Meanwhile, either the hydrolysis amount or the levels of enantioselectivity were influenced by the tubifex. After incubated for 24 h, about 94.6% of the DM was hydrolyzed and the enantiomer fraction of m...
Source: Chirality - September 18, 2023 Category: Molecular Biology Authors: Tiantian Liu Xinhong Duan Source Type: research
Rottlerin impairs early and late steps of Toxoplasma gondii infection in human trophoblast cells and villous explants
Chem Biol Interact. 2023 Sep 16:110716. doi: 10.1016/j.cbi.2023.110716. Online ahead of print.ABSTRACTCongenital toxoplasmosis, caused by the opportunistic protozoan parasite T. gondii, can cause stillbirths, miscarriages and fetal abnormalities, as well as encephalitis and chorioretinitis in newborns. Available treatment options rely on antiparasitic drugs that have been linked to serious side effects, high toxicity and the development of drug-resistant parasites. The search for alternative therapeutics to treat this disease without acute toxicity for the mother and child is essential for the advancement of current therap...
Source: Chemico-Biological Interactions - September 18, 2023 Category: Molecular Biology Authors: Samuel Cota Teixeira Marina Paschoalino Guilherme de Souza Alessandra Monteiro Rosini Joed Pires de Lima Junior Luana Carvalho Luz Aryani Felixa Fajardo Mart ínez Rosiane Nascimento Alves Marcos Paulo Oliveira Almeida Jaqueline Lopes Damasceno Marcelo Jo Source Type: research
Sequential detection of inflammation-related hypochlorite ions and viscosity with a relay fluorescent probe
Org. Biomol. Chem., 2023, Advance Article DOI: 10.1039/D3OB00967J, PaperYu-Qing Zhang, Zhi-Nan Kang, Jing-Jie Ming, Sheng-Nan Suo, Jia-Ling Kang, Hai Xu, Ya-Wen Wang, Yu Peng A new fluorescent probe has been developed for relay detection of hypochlorite ions and viscosity. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 18, 2023 Category: Molecular Biology Authors: Yu-Qing Zhang Source Type: research
Chlorogenic acid enhances PPAR γ-mediated lipogenesis through preventing Lipin 1 nuclear translocation in Staphylococcus aureus-exposed bovine mammary epithelial cells
In this study, the internalization of S. aureus reduced intracellular lipid droplet formation, decreased the levels of intracellular triacylglycerol, total cholesterol and 7 types of fatty acid and downregulated the expression of lipogenic genes FAS, ACC, and DGAT1 in bovine mammary epithelial cells (BMECs). In addition, we found that S. aureus intracellular infection attenuated mTORC1 activation resulting in Lipin 1 nuclear localization. Remarkablely, S. aureus infection-mediated repression of lipid synthesis related to the mTORC1 signaling and Lipin 1 nuclear localization can be alleviated by CGA. Thus, our findings prov...
Source: Mol Biol Cell - September 17, 2023 Category: Molecular Biology Authors: Ruiyuan Yao Manshulin Wang Yue Zhao Qiang Ji Xue Feng Linfeng Bai Lili Bao Yanfeng Wang Huifang Hao Xihe Li Zhigang Wang Source Type: research
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Mol Biol Rep. 2023 Sep 17. doi: 10.1007/s11033-023-08791-w. Online ahead of print.ABSTRACTThe unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and ...
Source: Mol Biol Cell - September 17, 2023 Category: Molecular Biology Authors: Asrarunissa Kalmatte Punchappady Devasya Rekha Chandrahas Koumar Ratnacaram Source Type: research
Regulation of sexually dimorphic placental adaptation in LPS exposure-induced intrauterine growth restriction
CONCLUSIONS: Our results present the sexually dimorphic responses of placental physiology in intrauterine growth restriction model and provide tentative relationship further to be elucidated between sex-biased placental functional change and long-term effects on the offspring's later life.PMID:37718409 | DOI:10.1186/s10020-023-00688-5
Source: Molecular Medicine - September 17, 2023 Category: Molecular Biology Authors: Da Som Jeong Ji-Yeon Lee Myoung Hee Kim Ji Hoon Oh Source Type: research
Medical education empowered by generative artificial intelligence large language models
Trends Mol Med. 2023 Sep 15:S1471-4914(23)00211-3. doi: 10.1016/j.molmed.2023.08.012. Online ahead of print.ABSTRACTGenerative artificial intelligence (GAI) large language models (LLMs), like ChatGPT, have become the world's fastest growing applications. Here, we provide useful strategies for educators in medical and health science (M&HS) to integrate GAI-LLMs into learning and teaching practice, ultimately enhancing students' digital capability.PMID:37718142 | DOI:10.1016/j.molmed.2023.08.012
Source: Molecular Medicine - September 17, 2023 Category: Molecular Biology Authors: Tanisha Jowsey Jessica Stokes-Parish Rachelle Singleton Michael Todorovic Source Type: research
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Mol Biol Rep. 2023 Sep 17. doi: 10.1007/s11033-023-08791-w. Online ahead of print.ABSTRACTThe unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and ...
Source: Molecular Biology Reports - September 17, 2023 Category: Molecular Biology Authors: Asrarunissa Kalmatte Punchappady Devasya Rekha Chandrahas Koumar Ratnacaram Source Type: research
Chlorogenic acid enhances PPAR γ-mediated lipogenesis through preventing Lipin 1 nuclear translocation in Staphylococcus aureus-exposed bovine mammary epithelial cells
In this study, the internalization of S. aureus reduced intracellular lipid droplet formation, decreased the levels of intracellular triacylglycerol, total cholesterol and 7 types of fatty acid and downregulated the expression of lipogenic genes FAS, ACC, and DGAT1 in bovine mammary epithelial cells (BMECs). In addition, we found that S. aureus intracellular infection attenuated mTORC1 activation resulting in Lipin 1 nuclear localization. Remarkablely, S. aureus infection-mediated repression of lipid synthesis related to the mTORC1 signaling and Lipin 1 nuclear localization can be alleviated by CGA. Thus, our findings prov...
Source: Mol Biol Cell - September 17, 2023 Category: Molecular Biology Authors: Ruiyuan Yao Manshulin Wang Yue Zhao Qiang Ji Xue Feng Linfeng Bai Lili Bao Yanfeng Wang Huifang Hao Xihe Li Zhigang Wang Source Type: research
Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
Mol Biol Rep. 2023 Sep 17. doi: 10.1007/s11033-023-08791-w. Online ahead of print.ABSTRACTThe unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and poor survival outcomes of oral cancer. This review summarizes the prior research and recent advancements on the influence of dysregulated non-coding RNA (ncRNA) on cell cycle and their employability as diagnostic and prognostic biomarkers of oral cancer. The literature search was performed using the following keywords: 'serum/saliva non-coding RNAs' and 'serum/saliva non-coding RNAs and ...
Source: Mol Biol Cell - September 17, 2023 Category: Molecular Biology Authors: Asrarunissa Kalmatte Punchappady Devasya Rekha Chandrahas Koumar Ratnacaram Source Type: research
Modulation of paraoxonase-2 in human dermal fibroblasts by UVA-induced oxidative stress: A new potential marker of skin photodamage
Chem Biol Interact. 2023 Sep 15:110702. doi: 10.1016/j.cbi.2023.110702. Online ahead of print.ABSTRACTParaoxonase-2 (PON2) is an intracellular protein widely expressed in many cell types and tissues, whose levels are known to be modulated by oxidative stress and apoptosis induced by genetic and environmental factors. However, an environmental factor that has not been previously explored is the effect of ultraviolet A radiation (UVA), the oxidizing component of sunlight, on the modulation of PON2 in human dermal fibroblasts (HuDe). Excessive UVA radiation is known to cause direct and indirect skin damage by influencing intr...
Source: Chemico-Biological Interactions - September 17, 2023 Category: Molecular Biology Authors: Camilla Morresi Alessia Luccarini Fabio Marcheggiani Gianna Ferretti Elisabetta Damiani Tiziana Bacchetti Source Type: research
Medical education empowered by generative artificial intelligence large language models
Trends Mol Med. 2023 Sep 15:S1471-4914(23)00211-3. doi: 10.1016/j.molmed.2023.08.012. Online ahead of print.ABSTRACTGenerative artificial intelligence (GAI) large language models (LLMs), like ChatGPT, have become the world's fastest growing applications. Here, we provide useful strategies for educators in medical and health science (M&HS) to integrate GAI-LLMs into learning and teaching practice, ultimately enhancing students' digital capability.PMID:37718142 | DOI:10.1016/j.molmed.2023.08.012
Source: Trends in Molecular Medicine - September 17, 2023 Category: Molecular Biology Authors: Tanisha Jowsey Jessica Stokes-Parish Rachelle Singleton Michael Todorovic Source Type: research
