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Rhodium(II)-catalyzed transannulation approach to N-fluoroalkylated indoles
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Olga Bakhanovich, Blanka Klepetarova, Petr Beier Copper(I)-catalyzed cycloaddition of substituted cyclohexenyl acetylenes with azido(per)fluoroalkanes afforded 4-cyclohexenyl-substituted N-(per)fluoroalkylated 1,2,3-triazoles. Their rhodium(II)-catalyzed transannulation led to fused N-(per)fluoroalkyl pyrroles and subsequent oxidation provided N-(per)fluoroalkyl indoles. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 21, 2023 Category: Molecular Biology Authors: Olga Bakhanovich Source Type: research
Efficient approach to 1,1 ′-bisindoles via copper(I)-catalyzed double domino reaction
Org. Biomol. Chem., 2023, Accepted Manuscript DOI: 10.1039/D3OB01231J, PaperAnn-Kathrin Bauer, J ürgen Conrad, Uwe Beifuss A highly efficient copper(I)-catalyzed approach for the synthesis of 1,1 ′-bisindoles that is based on the formation of four bonds in one step has been developed. The unprecedented three component reaction... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 21, 2023 Category: Molecular Biology Authors: Ann-Kathrin Bauer Source Type: research
A reaction-based scenario for fluorescence probing of Au(III) ions in human cells and plants
Org. Biomol. Chem., 2023, Advance Article DOI: 10.1039/D3OB01081C, CommunicationMerve Çevik Eren, Ahmet Eren, Suay Dartar, Beraat Umur Kaya, Muhammed Üçüncü, Canan Varlikli, Hüseyin Çağlar Karakaya, Mustafa Emrullahoğlu In the presence of gold ions, a BODIPY construct with an extended π-conjugation transforms into a new structure with a relatively short π-system, which can be monitored as distinct changes in the color of the emission in plants and human cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - September 21, 2023 Category: Molecular Biology Authors: Merve Çevik Eren Source Type: research
Distinct subtypes of spatial brain metabolism patterns in Alzheimer's disease identified by deep learning-based FDG PET clusters
CONCLUSION: We identified distinct subtypes of AD with different clinicopathologic features. The deep learning-based approach to distinguish AD subtypes on FDG PET could have implications for predicting individual outcomes and provide a clue to understanding the heterogeneous pathophysiology of AD.PMID:37735259 | DOI:10.1007/s00259-023-06440-9
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Hyun Gee Ryoo Hongyoon Choi Kuangyu Shi Axel Rominger Dong Young Lee Dong Soo Lee Alzheimer ’s Disease Neuroimaging Initiative Source Type: research
Patterns of PET-positive residual tissue at interim restaging and risk of treatment failure in advanced-stage Hodgkin's lymphoma: an analysis of the randomized phase III HD18 trial by the German Hodgkin Study Group
CONCLUSION: PET-2-positive residuals of AS-HL are mostly located in the mediastinum, and a majority of patients have few affected regions. The risk of progression was twofold higher in patients with more than two positive regions in PET-2.PMID:37735258 | DOI:10.1007/s00259-023-06431-w
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Justin Ferdinandus Lutz van Heek Katrin Roth Markus Dietlein Hans-Theodor Eich Christian Baues Peter Borchmann Carsten Kobe Source Type: research
Bioelectronic medicine potentiates endogenous NSCs for neurodegenerative diseases
Trends Mol Med. 2023 Sep 19:S1471-4914(23)00190-9. doi: 10.1016/j.molmed.2023.08.005. Online ahead of print.ABSTRACTNeurodegenerative diseases (NDs) are commonly observed and while no therapy is universally applicable, cell-based therapies are promising. Stem cell transplantation has been investigated, but endogenous neural stem cells (eNSCs), despite their potential, especially with the development of bioelectronic medicine and biomaterials, remain understudied. Here, we compare stem cell transplantation therapy with eNSC-based therapy and summarize the combined use of eNSCs and developing technologies. The rapid developm...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Maifu Yu Pin Sun Changkai Sun Wei-Lin Jin Source Type: research
Retracted IQGAP1 ‑siRNA inhibits proliferation and metastasis of U251 and U373 glioma cell lines
Mol Med Rep. 2023 Nov;28(5):207. doi: 10.3892/mmr.2023.13094. Epub 2023 Sep 21.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the GAPDH control western blotting data shown in Fig. 1C, and other western blotting data included in Figs. 2D and 7C and D, were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes. Owing to the fact that the contentious data in the above article were already under consideration for publication, or had already been published elsewhere, prior to its s...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Bo Diao Ying Liu Yi Zhang Jing Yu Jun Xie Guo-Zheng Xu Source Type: research
Britanin inhibits titanium wear particle ‑induced osteolysis and osteoclastogenesis
Mol Med Rep. 2023 Nov;28(5):205. doi: 10.3892/mmr.2023.13092. Epub 2023 Sep 21.ABSTRACTWear particle‑induced osteolysis is a serious complication that occurs in individuals with titanium (Ti)‑based implants following long‑term usage due to loosening of the implants. The control of excessive osteoclast differentiation and inflammation is essential for protecting against wear particle‑induced osteolysis. The present study evaluated the effect of britanin, a pseudoguaianolide sesquiterpene isolated from Inula japonica, on osteoclastogenesis in vitro and Ti particle‑induced osteolysis in vivo. The effect of britanin ...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Ju Ang Kim Soomin Lim Hye Jung Ihn Jung-Eun Kim Kyungmoo Yea Jimin Moon Hyukjae Choi Eui Kyun Park Source Type: research
Oxalate ‑induced renal pyroptotic injury and crystal formation mediated by NLRP3‑GSDMD signaling < em > in vitro < /em > and < em > in vivo < /em >
Mol Med Rep. 2023 Nov;28(5):209. doi: 10.3892/mmr.2023.13096. Epub 2023 Sep 21.ABSTRACTCalcium oxalate kidney stone has become an urgent issue due to its high incidence and recurrence rate. Thus, it is necessary to explore for mechanisms of calcium oxalate stones formation. Previous studies demonstrated that oxalate crystals could induce the activation of nucleotide‑binding domain and leucine‑rich repeat‑containing family pyrin domain‑containing 3 (NLRP3) inflammasome and change the renal tubular epithelium adhesion. However, the type and molecular mechanism of NLRP3 inflammasome‑mediated calcium oxalate stones f...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Yue Chen Shushuai Yang Hailong Kong Qi Wang Shiqun Chen Xingyu Wang Liqun Chen Shiyong Qi Source Type: research
Alteration of relative telomere length and telomerase reverse transcriptase expression in the granulosa cells of women during aging and assessment of < em > in vitro < /em > fertilization outcomes
Mol Med Rep. 2023 Nov;28(5):206. doi: 10.3892/mmr.2023.13093. Epub 2023 Sep 21.ABSTRACTTelomere attrition plays a critical role in the reproductive aging process in humans. Telomere length (TL) is typically regulated by telomerase, the main component of which is telomerase reverse transcriptase (TERT). The aim of the present study was to investigate the changes of relative TL (RTL) and TERT expression in granulosa cells (GCs) during aging and its association with reproduction. Clinical data on the frozen‑thawed embryo transfer cycles of older (>35 year old) and younger (≤35 year old) women from a single center over ...
Source: Molecular Medicine - September 21, 2023 Category: Molecular Biology Authors: Yan Hao Mingrong Lv Jing Peng Dan Kuang Zhihua Zhang Zhou Zhang Tingting Wang Bo Yang Zhaolian Wei Ping Zhou Zhiguo Zhang Yunxia Cao Source Type: research
Hyperbaric oxygen therapy suppresses hypoxia and reoxygenation injury to retinal pigment epithelial cells through activating peroxisome proliferator activator receptor-alpha signalling
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17963. Online ahead of print.ABSTRACTRetinal ischemia followed by reperfusion (IR) is a common cause of many ocular disorders, such as age-related macular degeneration (AMD), which leads to blindness in the elderly population, and proper therapies remain unavailable. Retinal pigment epithelial (RPE) cell death is a hallmark of AMD. Hyperbaric oxygen (HBO) therapy can improve IR tissue survival by inducing ischemic preconditioning responses. We conducted an in vitro study to examine the effects of HBO preconditioning on oxygen-glucose deprivation (OGD)-induced IR-injured RPE ce...
Source: J Cell Mol Med - September 21, 2023 Category: Molecular Biology Authors: Tzong-Bor Sun Kuo-Feng Huang Ko-Chi Niu Cheng-Hsien Lin Wen-Pin Liu Chao-Hung Yeh Shu-Chun Kuo Ching-Ping Chang Source Type: research
Transcriptome analysis of six tissues obtained post-mortem from sepsis patients
J Cell Mol Med. 2023 Sep 20. doi: 10.1111/jcmm.17938. Online ahead of print.ABSTRACTSeptic shock is a life-threatening clinical condition characterized by a robust immune inflammatory response to disseminated infection. Little is known about its impact on the transcriptome of distinct human tissues. To address this, we performed RNA sequencing of samples from the prefrontal cortex, hippocampus, heart, lung, kidney and colon of seven individuals who succumbed to sepsis and seven uninfected controls. We identified that the lungs and colon were the most affected organs. While gene activation dominated, strong inhibitory signa...
Source: J Cell Mol Med - September 21, 2023 Category: Molecular Biology Authors: Fabiano Pinheiro da Silva Andr é Nicolau Aquime Gonçalves Amaro Nunes Duarte-Neto Thomaz L üscher Dias Hermes Vieira Barbeiro Cristiane Naffah Souza Breda Leandro Carvalho Dantas Breda Niels Olsen Saraiva C âmara Helder I Nakaya Source Type: research
Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRA < sup > + < /sup > Myofibroblast
In this study, FGFR2 signaling was inhibited by temporal expression of a secreted dominant-negative FGFR2b (dnFGFR2) by AT2 cells from E16.5 to E18.5. Fibroblast and epithelial differentiation were analyzed at E18.5, PN7, and PN21. At all time points, the number of myofibroblasts was reduced and the number lipo/matrix fibroblasts was increased. AT2 cells are increased and AT1 cells are reduced postnatally, but not at E18.5. Similarly, in organoids made with PDGFRA+ fibroblasts from dnFGFR2 lungs, increased AT2 cells and reduced AT1 cells were observed. In vitro treatment of primary wild-type E16.5 adherent saccular lung fi...
Source: Mol Biol Cell - September 21, 2023 Category: Molecular Biology Authors: Matthew R Riccetti Jenna Green Thomas J Taylor Anne-Karina T Perl Source Type: research
Oestrogen receptor-independent actions of oestrogen in cancer
Mol Biol Rep. 2023 Sep 20. doi: 10.1007/s11033-023-08793-8. Online ahead of print.ABSTRACTOestrogen, the primary female sex hormone, plays a significant role in tumourigenesis. The major pathway for oestrogen is via binding to its receptor [oestrogen receptor (ERα or β)], followed by nuclear translocation and transcriptional regulation of target genes. Almost 70% of breast tumours are ER + , and endocrine therapies with selective ER modulators (tamoxifen) have been successfully applied. As many as 25% of tamoxifen-treated patients experience disease relapse within 5 years upon completion of chemotherapy. In such cases, t...
Source: Molecular Biology Reports - September 21, 2023 Category: Molecular Biology Authors: Prarthana Gopinath Revathi Paramasivam Oviya Gopal Gopisetty Source Type: research
Genome-wide identification and gene expression analysis of GHMP kinase gene family in banana cv. Rasthali
CONCLUSION: Our findings suggested that MaGHMP kinase1 (MaHSK) and MaGHMP kinase3 (MaGlcAK) could be considered promising candidates for thwarting the abiotic stresses in banana.PMID:37731027 | DOI:10.1007/s11033-023-08743-4
Source: Molecular Biology Reports - September 21, 2023 Category: Molecular Biology Authors: Siddhant Chaturvedi Shahirina Khan Neha Thakur Alka Jangra Siddharth Tiwari Source Type: research
