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Total 89913 results found since Jan 2013.
Suspected Legionella Transmission from a Single Donor to Two Lung Transplant Recipients - Pennsylvania, May 2022
MMWR Morb Mortal Wkly Rep. 2023 Sep 15;72(37):1001-1004. doi: 10.15585/mmwr.mm7237a1.ABSTRACTIn July 2022, the Pennsylvania Department of Health received two reports of laboratory-confirmed Legionnaires disease in patients who had recently received lung transplants from the same donor at a single Pennsylvania hospital. The donor's cause of death was freshwater drowning in a river, raising suspicion of potential donor-derived transmission, because Legionella bacteria naturally live in fresh water. Further investigation of patients receiving other organs from the same donor did not identify additional legionellosis cases. He...
Source: MMWR Morb Mortal Wkl... - September 14, 2023 Category: Epidemiology Authors: Shannon McGinnis Rebecca J Free Jacqueline Burnell Sridhar V Basavaraju Trevor Kanaskie Elizabeth J Hannapel Nottasorn Plipat Kimberly Warren Chris Edens Source Type: research
Letermovir and new horizons in prevention of post-transplant CMV
Expert Rev Clin Pharmacol. 2023 Sep 14. doi: 10.1080/17512433.2023.2259308. Online ahead of print.NO ABSTRACTPMID:37706302 | DOI:10.1080/17512433.2023.2259308
Source: Pharmacological Reviews - September 14, 2023 Category: Drugs & Pharmacology Authors: Emily A Siegrist Joseph Sassine Source Type: research
Treg-targeted IL-2/anti-IL-2 complex controls graft- < em > versus < /em > -host disease and supports anti-tumor effect in allogeneic hematopoietic stem cell transplantation
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2022.282653. Online ahead of print.ABSTRACTModulating an immune response in opposite directions represents the holy grail in allogeneic hematopoietic stem cell transplantation (allo-HSCT) to avoid insufficient reactivity of donor T cells and hematologic malignancy relapse while controlling the potential development of graft-versus-host disease (GVHD), in which donor T cells attack the recipient's tissues. IL-2/anti-IL-2 complexes (IL2-Cxs) represents a therapeutic option to selectively accentuate or dampen the immune response. In dedicated experimental models of allo-HSCT, ...
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Allan Thiolat Caroline Pilon Pamela Caudana Audrey Moatti Nhu Hanh To Christine Sedlik Mathieu Leclerc S ébastien Maury Eliane Piaggio Jos é L Cohen Source Type: research
Daratumumab and brentuximab vedotin combination therapy in T-cell acute lymphoblastic leukemia refractory to conventional chemotherapy and allogeneic stem cell transplant
Haematologica. 2023 Sep 14. doi: 10.3324/haematol.2023.283740. Online ahead of print.ABSTRACTNot available.PMID:37706335 | DOI:10.3324/haematol.2023.283740
Source: Haematologica - September 14, 2023 Category: Hematology Authors: Kebede H Begna Nadine H Abdallah Michelle Janania-Martinez Abhishek A Mangaonkar Aruna Rangan Jennifer L Herrick Naseema Gangat Source Type: research
Heart Retransplantation Under the 2018 Adult Heart Allocation Policy
CONCLUSIONS: Heart retransplantation candidates have experienced improved waitlist outcomes following the 2018 adult heart allocation policy without significant changes to post-transplant survival.PMID:37709159 | DOI:10.1016/j.athoracsur.2023.09.001
Source: The Annals of Thoracic Surgery - September 14, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Samuel T Kim Amit Iyengar Mark R Helmers Noah Weingarten David Rekhtman Cindy Song Max Shin Marisa Cevasco Pavan Atluri Source Type: research
Breast Cancer Organoids Derived from Patients: A Platform for Tailored Drug Screening
Biochem Pharmacol. 2023 Sep 12:115803. doi: 10.1016/j.bcp.2023.115803. Online ahead of print.ABSTRACTBreast cancer stands as the most prevalent and heterogeneous malignancy affecting women globally, posing a substantial health concern. Enhanced comprehension of tumor pathology and the development of novel therapeutics are pivotal for advancing breast cancer treatment. Contemporary breast cancer investigation heavily leans on in vivo models and conventional cell culture techniques. Nonetheless, these approaches often encounter high failure rates in clinical trials due to species disparities and tissue structure variations. ...
Source: Biochemical Pharmacology - September 14, 2023 Category: Drugs & Pharmacology Authors: Yen-Dun Tony Tzeng Jui-Hu Hsiao Ling-Ming Tseng Ming-Feng Hou Chia-Jung Li Source Type: research
Activated carbon derived from wood biochar for Amperometric sensing of Ammonia for early screening of chronic kidney disease
In this study, we have elucidated the functionality and usefulness of a wearable microelectronic research prototype integrated with an HTC-activated carbon @RTIL-based electrochemical sensing platform for detecting ammonia levels released from the skin as a marker for chronic kidney disease screening. By enabling early detection and monitoring, these platforms can facilitate timely interventions, such as lifestyle modifications, medication adjustments, or referral to nephrology specialists. This proactive approach can potentially slow down disease progression, minimize the need for dialysis or transplantation, and ultimate...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Ivneet Banga Anirban Paul Vikram Narayanan Dhamu Annapoorna Hochihally Ramasubramanya Sriram Muthukumar Shalini Prasad Source Type: research
Improving liver transplant outcomes with transplant-omics and network biology
Curr Opin Organ Transplant. 2023 Sep 13. doi: 10.1097/MOT.0000000000001100. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Molecular omics data is increasingly ubiquitous throughout medicine. In organ transplantation, recent large-scale research efforts are generating the 'transplant-ome' - the entire set of molecular omics data, including the genome, transcriptome, proteome, and metabolome. Importantly, early studies in anesthesiology have demonstrated how perioperative interventions alter molecular profiles in various patient populations. The next step for anesthesiologists and intensivists will be to tailor perioperat...
Source: Current Opinion in Organ Transplantation - September 14, 2023 Category: Transplant Surgery Authors: Joseph Scarpa Source Type: research
Extracorporeal Life Support in Pulmonary Hypertension: Practical Aspects
Semin Respir Crit Care Med. 2023 Sep 14. doi: 10.1055/s-0043-1772752. Online ahead of print.ABSTRACTExtracorporeal life support (ECLS), in particular veno-arterial extracorporeal membrane oxygenation, has emerged as a potentially life-saving treatment modality in patients presenting with pulmonary hypertension and right heart failure refractory to conventional treatment. Used mainly as a bridge to lung transplantation, ECLS is also being used occasionally as a bridge to recovery in patients with treatable causes of right heart failure. This review article describes indications, contraindications, techniques, and outcomes o...
Source: Respiratory Care - September 14, 2023 Category: Respiratory Medicine Authors: Marius M Hoeper Source Type: research
Renal outcomes in older adults with antineutrophil cytoplasmic autoantibody-associated vasculitis: a new prediction model
CONCLUSION: We established a risk-scoring system based on baseline clinical characteristics to predict composite renal outcomes in patients with AAV. Our results suggest that more attention should be paid to older patients with severe renal impairment and active inflammation.PMID:37708862 | DOI:10.1159/000533512
Source: American Journal of Nephrology - September 14, 2023 Category: Urology & Nephrology Authors: Shuo Zhang Xin Chen Zuoxian Hou Peng Xia Xiaoxiao Shi Haiting Wu Yubing Wen Yan Qin Xinping Tian Limeng Chen Source Type: research
Bortezomib and Vorinostat Therapy as Maintenance Therapy Post Autologous Transplant for Non-Hodgkin's Lymphoma Using R-BEAM or BEAM Transplant Conditioning Regimen
CONCLUSIONS: BV can be given post-ASCT for NHL and produces excellent disease-free and overall survival rates.PMID:37708877 | DOI:10.1159/000533944
Source: Acta Haematologica - September 14, 2023 Category: Hematology Authors: Leona A Holmberg David G Maloney Laura Connelly-Smith Source Type: research
Cladribine, Cytarabine, And Etoposide (CCE)-Based Regimens Are Safe and Tolerable In Relapsed And Refractory AML Patients
Acta Haematol. 2023 Sep 14. doi: 10.1159/000534024. Online ahead of print.ABSTRACTIntensive treatment regimens for relapsed/refractory (R/R) acute myeloid leukemia (AML) generally include an anthracycline, cytarabine, with or without a purine analogue. In patients who cannot tolerate an anthracycline due to comorbidities may consider using etoposide. Given the ongoing fludarabine shortage, it has prompted the switch to other purine analogues, such as cladribine, in combination with cytarabine and etoposide in patients who may be eligible for intensive chemotherapy but not able to tolerate an anthracycline due to comorbidit...
Source: Acta Haematologica - September 14, 2023 Category: Hematology Authors: Jose Tinajero Dat Ngo Amandeep Salhotra Paul Koller Source Type: research
Hyperbaric oxygen mitigates KIM-1 and inflammatory cytokine levels in kidney transplantation
Undersea Hyperb Med. 2023 Third Quarter;50(3):289-300.ABSTRACTThe aim of this study was to investigate the effect of hyperbaric oxygen (HBO2) administration during cold ischemic time to organs removed from donors before kidney transplantation. A total of 24 rats were divided into three groups: Group 1 was the control group, Group 2 received 60 minutes of HBO2 at 2.5 atmospheres absolute, and Group 3 received 120 minutes of 2.5 ATA HBO2. The renal artery was entered with a polyethylene catheter and perfused with a standard organ preservation solution. Falcon tubes containing organs obtained from rats in Groups 2 and 3 were ...
Source: Undersea and Hyperbaric Medicine - September 14, 2023 Category: Sports Medicine Authors: Ba şak Bűyűk Özlem Öztopuz Source Type: research
Breast Cancer Organoids Derived from Patients: A Platform for Tailored Drug Screening
Biochem Pharmacol. 2023 Sep 12:115803. doi: 10.1016/j.bcp.2023.115803. Online ahead of print.ABSTRACTBreast cancer stands as the most prevalent and heterogeneous malignancy affecting women globally, posing a substantial health concern. Enhanced comprehension of tumor pathology and the development of novel therapeutics are pivotal for advancing breast cancer treatment. Contemporary breast cancer investigation heavily leans on in vivo models and conventional cell culture techniques. Nonetheless, these approaches often encounter high failure rates in clinical trials due to species disparities and tissue structure variations. ...
Source: Biochemical Pharmacology - September 14, 2023 Category: Drugs & Pharmacology Authors: Yen-Dun Tony Tzeng Jui-Hu Hsiao Ling-Ming Tseng Ming-Feng Hou Chia-Jung Li Source Type: research
Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies < em > SPP1 < /em > < sup > + < /sup > Macrophage Subpopulation as a Target for Alleviating Fibrosis
CONCLUSIONS: SPP1+ macrophages accumulated in the PVAT surrounding atherosclerotic coronary arteries, and they promoted the migration and proliferation of fibroadipogenic progenitor cells via OPN-CD44/integrin interaction and thus aggravated the fibrosis of coronary PVAT, which was positively correlated to the coronary stenosis burden. Therefore, SPP1+ macrophages in coronary PVAT may participate in the progression of coronary atherosclerosis.PMID:37706320 | DOI:10.1161/ATVBAHA.123.319828
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Mengxia Fu Songren Shu Zhiming Peng Xiaorui Liu Xiao Chen Zhiwei Zeng Yicheng Yang Hao Cui Ruojin Zhao Xiaohu Wang Leilei Du Min Wu Wei Feng Jiangping Song Source Type: research
