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Core-Shell type lipid/rPAA-Chol polymer hybrid nanoparticles for in vivo siRNA delivery.
In this study, the core-shell type lipid/rPAA-Chol hybrid nanoparticles (PEG-LP/siRNA NPs and T7-LP/siRNA NPs) were developed for improving in vivo siRNA delivery by modifying the surface of rPAA-Chol/siRNA nanoplex core with a lipid shell, followed by post-insertion of polyethylene glycol phospholipid (DSPE-PEG) and/or peptide (HAIYPRH, named as T7) modified DSPE-PEG-T7. The integrative hybrid nanostructures of LP/siRNA NPs were evidenced by dynamic light scattering (DLS), confocal laser scanning microscope (CLSM), cryo-transmission electron microscope (Cryo-TEM) and surface plasmon resonance (SPR) assay. It was demonstr...
Source: Biomaterials - December 5, 2013 Category: Materials Science Authors: Gao LY, Liu XY, Chen CJ, Wang JC, Feng Q, Yu MZ, Ma XF, Pei XW, Niu YJ, Qiu C, Pang WH, Zhang Q Tags: Biomaterials Source Type: research

Evaluation of an Integrin αvβ3 Radiotracer, 18FF-FPP-RGD2, for Monitoring Pharmacological Effects of Integrin αv siRNA in the NASH Liver
ConclusionThis study suggests that [18F]F-FPP-RGD2 PET imaging is a promising radiotracer for monitoring hepatic integrin αv protein levels and hepatic function in NASH pathology.
Source: Nuclear Medicine and Molecular Imaging - March 7, 2023 Category: Nuclear Medicine Source Type: research

The effects of array structure and secondary cognitive task demand on processes of visual search.
Abstract Many aspects of our everyday behaviour require that we search for objects. However, in real situations search is often conducted while internal and external factors compete for our attention resources. Cognitive distraction interferes with our ability to search for targets, increasing search times. Here we consider whether effects of cognitive distraction interfere differentially with three distinct phases of search: initiating search, overtly scanning through items in the display, and verifying that the object is indeed the target of search once it has been fixated. Furthermore, we consider whether strat...
Source: Vision Research - September 21, 2018 Category: Opthalmology Authors: Savage SW, CPsychol, Potter DD, Tatler BW Tags: Vision Res Source Type: research

Job search self-regulation during COVID-19: Linking search constraints, health concerns, and invulnerability to job search processes and outcomes.
The COVID-19 pandemic has caused tremendous job loss and made it difficult for unemployed individuals to search for new jobs. Specifically, the pandemic has created numerous job search obstacles, such as increased childcare and community responsibilities, that interfere with job seekers’ ability to search for a job. Yet, the job search literature has scantily examined the implications of such job search constraints for job seekers even in normal times, and the limited studies that do exist have produced mostly null findings. Drawing from self-regulation theories, we position COVID-19 job search constraints as a catalyst ...
Source: Journal of Applied Psychology - August 12, 2021 Category: Psychiatry & Psychology Source Type: research

Seasonal variation in seeking help for domestic violence based on Google search data and Finnish police calls in 2017.
CONCLUSIONS: The study suggests that Google search volumes can be used to study the highest peaks in seeking help for domestic violence in countries with a high level of Internet usage and no available police data. PMID: 30973072 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Public Health - April 10, 2019 Category: International Medicine & Public Health Authors: Koutaniemi EM, Einiö E Tags: Scand J Public Health Source Type: research

The search for extraterrestrial intelligence - podcast
The most intensive ever search for alien lifeThis week it was revealed that astronomers are about to start the most intensive ever search for alien life. The Breakthrough Listen project will scan stars in 100 galaxies for radio and optical signatures that indicate someone, or something, is out there.Until now, the search for extraterrestrial intelligence - or SETI - has been met with an eerie silence. What makes scientists so convinced it's worthwhile looking for alien life? Continue reading...
Source: Guardian Unlimited Science - July 24, 2015 Category: Science Authors: Hannah Devlin Tags: Science Astronomy Seti (Search for Extraterrestrial Intelligence) Source Type: news

Evaluation of an Integrin α < sub > v < /sub > β < sub > 3 < /sub > Radiotracer, < sup > 18 < /sup > FF-FPP-RGD < sub > 2 < /sub > , for Monitoring Pharmacological Effects of Integrin α < sub > v < /sub > siRNA in the NASH Liver
CONCLUSION: This study suggests that [18F]F-FPP-RGD2 PET imaging is a promising radiotracer for monitoring hepatic integrin αv protein levels and hepatic function in NASH pathology.PMID:37483876 | PMC:PMC10359219 | DOI:10.1007/s13139-023-00791-9
Source: Molecular Medicine - July 24, 2023 Category: Molecular Biology Authors: Shuichi Hiroyama Keiko Matsunaga Miwa Ito Hitoshi Iimori Ippei Morita Jun Nakamura Eku Shimosegawa Kohji Abe Source Type: research

Eco-friendly deacetylated chitosan base siRNA biological-nanopesticide loading cyromazine for efficiently controlling Spodoptera frugiperda
Int J Biol Macromol. 2023 Apr 24:124575. doi: 10.1016/j.ijbiomac.2023.124575. Online ahead of print.ABSTRACTSpodoptera frugiperda is a serious threat to various crops, such as corn and rice, and results in severe economic losses. Herein, a chitin synthase sfCHS highly expressed in the epidermis of S. frugiperda was screened, and when interfered by an sfCHS-siRNA nanocomplex, most individuals could not ecdysis (mortality rate 53.3 %) or pupate (abnormal pupation 80.6 %). Based on the results of structure-based virtual screening, cyromazine (CYR, binding free energy -57.285 kcal/mol) could inhibit ecdysis (LC50, 19.599 μg/g...
Source: International Journal of Biological Macromolecules - April 26, 2023 Category: Biochemistry Authors: Changwei Gong Ali Hasnain Qiulin Wang Dan Liu Zhengze Xu Xiaoxu Zhan Xuemei Liu Jian Pu Mengmeng Sun Xuegui Wang Source Type: research

Overcoming the non-kinetic activity of EGFR1 using multi-functionalized mesoporous silica nanocarrier for in vitro delivery of siRNA
Sci Rep. 2022 Oct 14;12(1):17208. doi: 10.1038/s41598-022-21601-w.ABSTRACTTriple-negative breast cancer (TNBC) does not respond to HER2-targeted and hormone-based medicines. Epidermal growth factor receptor 1 (EGFR1) is commonly overexpressed in up to 70% of TNBC cases, so targeting cancer cells via this receptor could emerge as a favored modality for TNBC therapy due to its target specificity. The development of mesoporous silica nanoparticles (MSNs) as carriers for siRNAs remains a rapidly growing area of research. For this purpose, a multi-functionalized KIT-6 containing the guanidinium ionic liquid (GuIL), PEI and PEGy...
Source: Cancer Control - October 14, 2022 Category: Cancer & Oncology Authors: Javad Parnian Leila Ma'mani Mohamad Reza Bakhtiari Maliheh Safavi Source Type: research

A biodegradable stearylated peptide with internal disulfide bonds for efficient delivery of siRNA in vitro and in vivo.
In this study, a stearyl-peptide (SHR) was synthesized using arginine, histidine, cysteine and stearyl moiety. Further, the stearyl-peptides were cross linked by disulfide bonds to obtain cross-linked polypeptides (SHRss) with different molecular weight (SHRss1, SHRss2, SHRss3, SHRss4). The SHRss could effectively condense small interfering RNA (siRNA) into polyplexes with a hydrodynamic size of 100-300 nm and zeta potential of 20-40 mV. Flow cytometry and confocal laser scanning microscope studies revealed high cellular uptake and rapid dissociation behavior of SHRss2/siRNA complexes. Long-lasting high concentration of si...
Source: Biomacromolecules - February 16, 2015 Category: Biochemistry Authors: Tai Z, Wang X, Tian J, Gao Y, Zhang L, Yao C, Wu X, Zhang W, Zhu Q, Gao S Tags: Biomacromolecules Source Type: research

Effects of hydrophobic core components in amphiphilic PDMAEMA nanoparticles on siRNA delivery.
Abstract Due to their biodegradable character, polyesters such as polycaprolactone (PCL), poly(d,l-lactide) (PDLLA), and polylactic-co-glycolic acid (PLGA) were widely used as the hydrophobic cores of amphiphilic cationic nanoparticles (NPs) for siRNA delivery. However, fewer researches focused on facilitating siRNA delivery by adjusting the polyester composition of these nanoparticles. Herein, we investigated the contribution of polyester segments in siRNA delivery in vitro by introducing different ratio of DLLA moieties in PCL segments of mPEG-block-PCL-graft-poly(dimethylamino ethyl methacrylate)(PEG-b-PCL-g-P...
Source: Biomaterials - February 25, 2015 Category: Materials Science Authors: Han S, Cheng Q, Wu Y, Zhou J, Long X, Wei T, Huang Y, Zheng S, Zhang J, Deng L, Wang X, Liang XJ, Cao H, Liang Z, Dong A Tags: Biomaterials Source Type: research

Abstract LB-102: Layer-by-layer engineering of upconversion nanoparticle based siRNA and miRNA delivery system for cancer therapy
Conclusions: In this proof-of-concept study, a layer-by-layer engineered UCNP based siRNA and miRNA delivery system was successfully developed. Our novel delivery system opens up preparation of advanced UCNP based photoresponsive delivery systems that allow remote, precise, and trackable control over therapeutic payload (e.g., drug, gene) release for better cancer theranostics.Citation Format: Lin Min, YAN GAO, Francis J. Hornicek, Mansoor M. Amiji, Zhenfeng Duan. Layer-by-layer engineering of upconversion nanoparticle based siRNA and miRNA delivery system for cancer therapy. [abstract]. In: Proceedings of the 106th Annual...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Min, L., GAO, Y., Hornicek, F. J., Amiji, M. M., Duan, Z. Tags: Cancer Chemistry Source Type: research

Phenylboronic acid-functionalized polyamidoamine-mediated Bcl-2 siRNA delivery for inhibiting the cell proliferation.
In conclusion, the PPP-mediated Bcl-2 siRNA delivery could potentially be an effective platform for solving the drug resistance and further achieving the combined chemotherapy and gene therapy in tumor treatment. PMID: 27371891 [PubMed - as supplied by publisher]
Source: Colloids and Surfaces - June 19, 2016 Category: Biotechnology Authors: Wu D, Yang J, Xing Z, Han H, Wang T, Zhang A, Yang Y, Li Q Tags: Colloids Surf B Biointerfaces Source Type: research