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IJERPH, Vol. 17, Pages 2388: The Relationship Exploration between Public Migration Attention and Population Migration from a Perspective of Search Query
Duan Rapid population migration has been viewed as a critical factor impacting urban network construction and regional sustainable development. The supervision and analysis of population migration are necessary for guiding the optimal allocation of urban resources and for attaining the high efficiency development of region. Currently, the explorations of population migration are often restricted by the limitation of data. In the information era, search engines widely collect public attention, implying potential individual actions, and freely provide open, timelier, and large-scope search query data for helping explore...
Source: International Journal of Environmental Research and Public Health - March 31, 2020 Category: Environmental Health Authors: Chun Li Jianhua He Xingwu Duan Tags: Article Source Type: research

Impact of a health campaign on Chinese public awareness of stroke: evidence from internet search data
Conclusions The WSD campaign increased internet search activity. These research techniques can be applied to evaluation of other health campaigns. Advancing understanding of public demand will enable tailoring of the campaign and strengthen health management.
Source: BMJ Open - December 14, 2021 Category: General Medicine Authors: Cao, M., Guan, T., Han, X., Shen, B., Chao, B., Liu, Y. Tags: Open access, Public health Source Type: research

Auranofin, an Anti-rheumatic Gold Drug, Aggravates the Radiation-Induced Acute Intestinal Injury in Mice
Conclusion In this study, we found that a non-toxic dose of auranofin significantly aggravated the severity of the radiation-induced intestinal injury. This suggests that auranofin treatment can be an independent factor that influences the risk of intestinal complications after pelvic or abdominal radiotherapy. Ethics Statement All the protocols used in this study were approved by the Institutional Animal Care and Use Committee of the Korean Institute of Radiological and Medical Sciences (IACUC permit number: KIRAMS217-0007). Author Contributions H-JL, JS, and Y-BL designed the experiments. EL and JK conducted the exp...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

Designing potential siRNA molecule for the nucleocapsid(N) gene silencing of different SARS-CoV-2 strains of Bangladesh: Computational approach
In this study, we attempted to design a siRNA molecule to silence the most suitable nucleocapsid(N) gene of SARS-CoV-2, which play a major role during viral pathogenesis, replication, encapsidation and RNA packaging. At first, 270 complete N gene sequences of different strains in Bangladesh of these viruses were retrieved from the NCBI database. Different computational methods were used to design siRNA molecules. A siRNA molecule was built against these strains using the SiDirect 2.0 server. Using Mfold and the OligoCalc server, the siRNA molecule was tested for its secondary structure and GC material. The Clustal Omega to...
Source: Computational Biology and Chemistry - May 13, 2021 Category: Bioinformatics Authors: Syed Shahariar Bappy Abu Zaffar Shibly Sorna Sultana A K M Mohiuddin Yearul Kabir Source Type: research

Naringenin Produces Neuroprotection Against LPS-Induced Dopamine Neurotoxicity via the Inhibition of Microglial NLRP3 Inflammasome Activation
Conclusions: This study demonstrated that NAR targeted microglial NLRP3 inflammasome to protect DA neurons against LPS-induced neurotoxicity. These findings suggest NAR might hold a promising therapeutic potential for PD. Background Parkinson's disease (PD) is the second most prevalent central nervous system (CNS) degenerative disease. It is characterized by slow and progressive loss of dopamine (DA) neurons in the midbrain substantia nigra (SN) with the accumulation of α-synuclein in Lewy bodies and neuritis (1). Although the etiology of PD remains unclear, amounts of studies have suggested that ne...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells
Conclusions: We propose that the inhibition of chromatin assembly represents a novel mechanism of cell transformation induced by the environmental and occupational chemical carcinogen FA. https://doi.org/10.1289/EHP1275 Received: 25 October 2016 Revised: 19 May 2017 Accepted: 23 May 2017 Published: 21 September 2017 Address correspondence to C. Jin, Dept. of Environmental Medicine, New York University School of Medicine, 57 Old Forge Rd., Tuxedo Park, NY 10987 USA. Telephone: (845) 731-3602. Email: Chunyuan.jin@nyumc.org *Current affiliation: Medical School of Nanjing University, Nanjing, China. †Current affiliatio...
Source: EHP Research - September 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Small interfering RNA targeting of keratin 17 reduces inflammation in imiquimod-induced psoriasis-like dermatitis.
CONCLUSIONS: Inhibition of K17 expression by its specific siRNA significantly alleviated inflammation in mice with IMQ-induced psoriasis-like dermatitis. Thus, gene therapy targeting K17 may be a potential treatment approach for psoriasis. PMID: 33237695 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - November 20, 2020 Category: General Medicine Authors: Xiao CY, Zhu ZL, Zhang C, Fu M, Qiao HJ, Wang G, Dang EL Tags: Chin Med J (Engl) Source Type: research

Advances in quantum dot-mediated siRNA delivery
Publication date: Available online 13 July 2017 Source:Chinese Chemical Letters Author(s): Zhi-Yao He, Zhao-Hui Jin, Mei Zhan, Zhou Qin, Zhi Li, Ting Xu Nano-sized quantum dots (QDs) exhibit uniquely optical properties that are tunable with different sizes and shapes. QDs can emit narrow symmetric bands under a wide excitation range, possess anti-photobleaching stability, and be bio-functionalized on the large surface area. Therefore, QDs are attractive vectors for imaging-guided therapy. Small-interfering RNA (siRNAs)-based therapeutics hold great potential to target a large part of the currently undruggable genes, but o...
Source: Chinese Chemical Letters - July 14, 2017 Category: Chemistry Source Type: research

Xuefu Zhuyu Oral Liquid ( 血府逐瘀口服液) Prevents Apoptosis of Ischemic Myocardium Cells in Rats by Regulating SIRT1 and Its Pathway-Related Genes
ConclusionXFZY could prevent myocardial cells apoptosis probably by increasing the mRNA and protein expressions of SIRT1 and inhibiting the mRNA and protein expressions of P53, NF- K B, FoxO1, FoxO3 and FoxO4.
Source: Chinese Journal of Integrative Medicine - December 22, 2019 Category: Internal Medicine Source Type: research

siRNA Mediated Silencing of NIN1/RPN12 Binding Protein 1 Homolog Inhibits Proliferation and Growth of Breast Cancer Cells
Authors: Huang WY, Chen DH, Ning L, Wang LW Abstract Retraction: Retracted: siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells Asian Pacific Journal of Cancer Prevention has retracted the article titled “siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells”(1) for reason of similarity with a series of articles identified by Byrne and Labbé (2). 1. Huang WY1, Chen DH, Ning L, Wang LW. siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation ...
Source: Asian Pacific Journal of Cancer Prevention - November 14, 2017 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Retracted: Silencing of the COPS3 Gene by siRNA Reduces Proliferation of Lung Cancer Cells Most Likely via Induction of Cell Cycle Arrest and Apoptosis
Authors: Abstract Retraction: Retracted: siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells Asian Pacific Journal of Cancer Prevention has retracted the article titled “siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells”(1) for reason of similarity with a series of articles identified by Byrne and Labbé (2). 1. Huang WY1, Chen DH, Ning L, Wang LW. siRNA mediated silencing of NIN1/RPN12 binding protein 1 homolog inhibits proliferation and growth of breast cancer cells. A...
Source: Asian Pacific Journal of Cancer Prevention - November 19, 2017 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

The Influence of College Students' Core Self-evaluation on Job Search Outcomes: Chain Mediating Effect of Career Exploration and Career Adaptability
Curr Psychol. 2022 Feb 23:1-12. doi: 10.1007/s12144-022-02923-4. Online ahead of print.ABSTRACTThe study of college students' job search and influencing factors has been an important topic in college students' career development. The degree of satisfaction with the results of a college student's perceived job search directly affects the sustainability of his or her future career. Although the importance of core self-evaluation in the job search process has been confirmed by a large body of literature, very little literature has focused on the mechanism of action between core self-evaluation and job search outcomes. Therefo...
Source: Current Psychology - March 1, 2022 Category: Psychiatry & Psychology Authors: Huaruo Chen Fei Liu Ya Wen Source Type: research