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Perioperative Pain Management for Distal Radius Fractures
Orthop Clin North Am. 2023 Oct;54(4):463-470. doi: 10.1016/j.ocl.2023.05.006. Epub 2023 Jun 26.ABSTRACTDistal radius fractures have a high incidence among both young and elderly patients, and in many instances require operative intervention. When operative intervention is employed, adequate pain management is essential to decrease postoperative complications, such as chronic pain and disability, while minimizing the risk of prolonged opioid use and dependence. Strategies to optimize pain management include regional anesthesia, preoperative dosing of medication, multimodal regimens, long-acting selective opioids at the time...
Source: The Orthopedic Clinics of North America - September 17, 2023 Category: Orthopaedics Authors: Nolan Farrell Paul T Greenfield Paul T Rutkowski William Jacob Weller Source Type: research

Management of Acute Cerebral Infarction by Intravenous Thrombolysis with Recombinant T Cell Receptor and Plasminogen Activator and Association of Emergency Nursing Route in the Prognosis
In this study, 100 patients were randomly selected that were equally divided into experimental and control groups. The period of hospital admission, the results of the Montreal Cognitive Assessment (MoCA) and the Mini-mental State Examination (MMSE), the results of the Glasgow Outcome Scale (GOS), and the results of the Activities of Daily Living were all analysed before and after the intervention.. Both the amount of time it took to get a diagnosis after being admitted and the amount of time it took to receive specialised therapy after receiving a diagnosis were significantly reduced in the observation group (both P value...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: None Yuqi Liu None Chengyong Wang None Yuanpeng Han Source Type: research

Accommodating Students with Disabilities: Fieldwork Educators' Experiences
Conclusion. Fieldwork educators can work with students to align their accommodations with required learning outcomes for professional practice and use their occupational therapy skills to assist with implementation. Fieldwork educators require time and other supports to work effectively with all students.PMID:37715626 | DOI:10.1177/00084174231201703
Source: Canadian Journal of Occupational Therapy - September 16, 2023 Category: Occupational Health Authors: Shaminder K Dhillon Sandra E Moll Magda Stroinska Patricia E Solomon Source Type: research

A Model of the Home Literacy Environment and Family Risk of Reading Difficulty in Relation to Children's Preschool Emergent Literacy
This study extends the research on the preschool home literacy environment (HLE) in the context of the family risk (FR) of reading disability (RD) by examining a multiple-deficit model of RD. A total of 1171 six-year-old children were assessed at school entry, the onset of formal reading instruction in Norway. Their parents completed a questionnaire regarding their own RD, education, and the HLE. The final sample after applying the inclusion criteria was 794 children and their parents. The findings suggest, first, that two HLE factors (access to print and reading-related activities) should be distinguished rather than trea...
Source: Journal of Learning Disabilities - September 16, 2023 Category: Disability Authors: Sara Esmaeeli Source Type: research

Reliability and validation of the Chinese version of the epilepsy surgery satisfaction questionnaire
CONCLUSIONS: The C-ESSQ-19 has proven to be a reliable and valid self-rated questionnaire for assessing the satisfaction of Chinese mainland epilepsy patients with surgery.PMID:37716327 | DOI:10.1016/j.yebeh.2023.109438
Source: Epilepsy and Behaviour - September 16, 2023 Category: Neurology Authors: Qun Yu Yu-Qi Ying Si-Xuan Jiang Zheng-Yan-Ran Xu Mei-Juan Lan Yi Guo Source Type: research

Genetic diagnostic yield in an 11-year cohort of craniosynostosis patients
Eur J Med Genet. 2023 Sep 14:104843. doi: 10.1016/j.ejmg.2023.104843. Online ahead of print.ABSTRACTCraniosynostosis may present in isolation, 'non-syndromic', or with additional congenital anomalies/neurodevelopmental disorders, 'syndromic'. Clinical focus shifted from confirming classical syndromic cases to offering genetic testing to all craniosynostosis patients. This retrospective study assesses diagnostic yield of molecular testing by investigating prevalences of chromosomal and monogenic (likely) pathogenic variants in an 11-year cohort of 1020 craniosynostosis patients. 502 children underwent genetic testing. Patho...
Source: European Journal of Medical Genetics - September 16, 2023 Category: Genetics & Stem Cells Authors: Linda Gaillard Anne Goverde Marjolein J A Weerts Annelies de Klein Irene M J Mathijssen Marieke F Van Dooren Source Type: research

Home-based exercise improves subclinical atherosclerosis marker in multiple sclerosis
CONCLUSION: The EX group had modest, yet significant, increases in aerobic capacity over the 12-week period, coupled with improvements in T25FW speed and vasodilatory reactivity. A home-based exercise intervention can improve outcomes of a subclinical marker of atherosclerosis, which provides a basis for examining these outcomes in persons prescreened for CVD-related comorbidities and/or mobility issues.PMID:37716212 | DOI:10.1016/j.msard.2023.105002
Source: Atherosclerosis - September 16, 2023 Category: Cardiology Authors: Tracy Baynard Garett J Griffith Sang Ouk Wee Neil J McMillan Rachel E Bollaert Robert W Motl Bo Fernhall Source Type: research

Contribution and therapeutic value of mitophagy in cerebral ischemia-reperfusion injury after cardiac arrest
Biomed Pharmacother. 2023 Sep 14;167:115492. doi: 10.1016/j.biopha.2023.115492. Online ahead of print.ABSTRACTCardiopulmonary resuscitation and related life support technologies have improved substantially in recent years; however, mortality and disability rates from cardiac arrest (CA) remain high and are closely associated with the high incidence of cerebral ischemia-reperfusion injury (CIRI), which is explained by a "double-hit" model (i.e., resulting from both ischemia and reperfusion). Mitochondria are important power plants in the cell and participate in various biochemical processes, such as cell differentiation and...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Zheng Li Jihong Xing Source Type: research

A Model of the Home Literacy Environment and Family Risk of Reading Difficulty in Relation to Children's Preschool Emergent Literacy
This study extends the research on the preschool home literacy environment (HLE) in the context of the family risk (FR) of reading disability (RD) by examining a multiple-deficit model of RD. A total of 1171 six-year-old children were assessed at school entry, the onset of formal reading instruction in Norway. Their parents completed a questionnaire regarding their own RD, education, and the HLE. The final sample after applying the inclusion criteria was 794 children and their parents. The findings suggest, first, that two HLE factors (access to print and reading-related activities) should be distinguished rather than trea...
Source: Journal of Learning Disabilities - September 16, 2023 Category: Disability Authors: Sara Esmaeeli Source Type: research

Home-based exercise improves subclinical atherosclerosis marker in multiple sclerosis
CONCLUSION: The EX group had modest, yet significant, increases in aerobic capacity over the 12-week period, coupled with improvements in T25FW speed and vasodilatory reactivity. A home-based exercise intervention can improve outcomes of a subclinical marker of atherosclerosis, which provides a basis for examining these outcomes in persons prescreened for CVD-related comorbidities and/or mobility issues.PMID:37716212 | DOI:10.1016/j.msard.2023.105002
Source: Atherosclerosis - September 16, 2023 Category: Cardiology Authors: Tracy Baynard Garett J Griffith Sang Ouk Wee Neil J McMillan Rachel E Bollaert Robert W Motl Bo Fernhall Source Type: research

The cell-specific roles of Nrf2 in acute and chronic phases of ischemic stroke
CNS Neurosci Ther. 2023 Sep 16. doi: 10.1111/cns.14462. Online ahead of print.ABSTRACTIschemic stroke refers to the sudden loss of blood flow in a specific area of the brain. It is the fifth leading cause of mortality and the leading cause of permanent disability. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) controls the production of several antioxidants and protective proteins and it has been investigated as a possible pharmaceutical target for reducing harmful oxidative events in brain ischemia. Each cell type exhibits different roles and behaviors in different phases post-stroke, which is...
Source: CNS Neuroscience and Therapeutics - September 16, 2023 Category: Neuroscience Authors: George Fadoul Milos Ikonomovic Feng Zhang Tuo Yang Source Type: research

Contribution and therapeutic value of mitophagy in cerebral ischemia-reperfusion injury after cardiac arrest
Biomed Pharmacother. 2023 Sep 14;167:115492. doi: 10.1016/j.biopha.2023.115492. Online ahead of print.ABSTRACTCardiopulmonary resuscitation and related life support technologies have improved substantially in recent years; however, mortality and disability rates from cardiac arrest (CA) remain high and are closely associated with the high incidence of cerebral ischemia-reperfusion injury (CIRI), which is explained by a "double-hit" model (i.e., resulting from both ischemia and reperfusion). Mitochondria are important power plants in the cell and participate in various biochemical processes, such as cell differentiation and...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 16, 2023 Category: Drugs & Pharmacology Authors: Zheng Li Jihong Xing Source Type: research

Omega-3 polyunsaturated fatty acids and the psychiatric post-acute sequelae of COVID-19: A one-year retrospective cohort analysis of 33,908 patients
CONCLUSION: Omega-3 PUFAs may require re-evaluation as a preventive strategy against adverse mental health outcomes post-COVID-19 in placebo-controlled clinical trials.PMID:37716377 | DOI:10.1016/j.bbi.2023.09.008
Source: Brain, Behavior, and Immunity - September 16, 2023 Category: Neurology Authors: Ting-Hui Liu Chung-Han Ho Daniel Tzu-Li Chen Jheng-Yan Wu Po-Yu Huang Chih-Cheng Lai Kuang-Yang Hsieh Kuan-Pin Su Source Type: research

Management of Acute Cerebral Infarction by Intravenous Thrombolysis with Recombinant T Cell Receptor and Plasminogen Activator and Association of Emergency Nursing Route in the Prognosis
In this study, 100 patients were randomly selected that were equally divided into experimental and control groups. The period of hospital admission, the results of the Montreal Cognitive Assessment (MoCA) and the Mini-mental State Examination (MMSE), the results of the Glasgow Outcome Scale (GOS), and the results of the Activities of Daily Living were all analysed before and after the intervention.. Both the amount of time it took to get a diagnosis after being admitted and the amount of time it took to receive specialised therapy after receiving a diagnosis were significantly reduced in the observation group (both P value...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: None Yuqi Liu None Chengyong Wang None Yuanpeng Han Source Type: research

The cell-specific roles of Nrf2 in acute and chronic phases of ischemic stroke
CNS Neurosci Ther. 2023 Sep 16. doi: 10.1111/cns.14462. Online ahead of print.ABSTRACTIschemic stroke refers to the sudden loss of blood flow in a specific area of the brain. It is the fifth leading cause of mortality and the leading cause of permanent disability. The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) controls the production of several antioxidants and protective proteins and it has been investigated as a possible pharmaceutical target for reducing harmful oxidative events in brain ischemia. Each cell type exhibits different roles and behaviors in different phases post-stroke, which is...
Source: CNS Neuroscience and Therapeutics - September 16, 2023 Category: Neuroscience Authors: George Fadoul Milos Ikonomovic Feng Zhang Tuo Yang Source Type: research