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Therapy: Stem Cell Therapy
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Total 3267 results found since Jan 2013.
An Analysis of how Herpes Zoster Pain affects Health Related Quality of Life of Placebo subjects from Three Randomized Phase III Studies
DISCUSSION: Moderate and severe HZ pain had a substantial negative impact on all aspects of HRQoL and ADL. This impact was independent of age and immunosuppression.PMID:37166199 | DOI:10.1097/AJP.0000000000001129
Source: Herpes - May 11, 2023 Category: Infectious Diseases Authors: Sean Matthews Desmond Curran Eliazar Sabater Cabrera C éline Boutry Nicolas Lecrenier Anthony L Cunningham Kenneth Schmader Source Type: research
Cannabidiol for musculoskeletal regenerative medicine
Exp Biol Med (Maywood). 2023 May 9:15353702231162086. doi: 10.1177/15353702231162086. Online ahead of print.ABSTRACTChronic musculoskeletal (MSK) pain is one of the most prevalent causes, which lead patients to a physician's office. The most common disorders affecting MSK structures are osteoarthritis, rheumatoid arthritis, back pain, and myofascial pain syndrome, which are all responsible for major pain and physical disability. Although there are many known management strategies currently in practice, phytotherapeutic compounds have recently begun to rise in the medical community, especially cannabidiol (CBD). This natura...
Source: Pain Physician - May 9, 2023 Category: Anesthesiology Authors: Gabriel Ohana Marques Azzini Vitor Ohana Marques Azzini Gabriel Silva Santos Silvia Visoni Maria Alice Fusco Natascha Szumsztajn Beker Ansar Mahmood Jo ão Vitor Bizinotto Lana Madhan Jeyaraman Arulkumar Nallakumarasamy Naveen Jeyaraman Lucas Furtado da F Source Type: research
Paeoniflorin promotes intestinal stem cell-mediated epithelial regeneration and repair via PI3K-AKT-mTOR signalling in ulcerative colitis
In this study, we investigated how PF could regulate the renewal and differentiation of intestinal stem cells (ISCs) to improve the regeneration and repair of the intestinal epithelium in UC. Our experimental results showed that PF significantly alleviated colitis induced by dextran sulfate sodium (DSS) and ameliorated intestinal mucosal injury by regulating the renewal and differentiation of ISCs. The mechanism by which PF regulates ISCs was confirmed to be through PI3K-AKT-mTOR signalling. In vitro, we found that PF not only improved the growth of TNF-α-induced colon organoids but also increased the expression of genes ...
Source: International Immunopharmacology - May 9, 2023 Category: Allergy & Immunology Authors: Yujing Ma Xiaomeng Lang Qian Yang Yan Han Xin Kang Run Long Jingxia Du Mengmeng Zhao Longhui Liu Peitong Li Jianping Liu Source Type: research
Exosome-mediated repair of intervertebral disc degeneration: The potential role of miRNAs
This article reviews the current status of research on intervertebral disc repair, especially with regard to the latest research findings on the molecular biological mechanisms of miRNAs in MSC-derived exosomes in intervertebral disc repair.PMID:37150986 | DOI:10.2174/1574888X18666230504094233
Source: Current Stem Cell Research and Therapy - May 8, 2023 Category: Stem Cells Authors: Hanshi Wang Shu Lin Haiming Yu Source Type: research
Kartogenin-loaded hydrogel promotes intervertebral disc repair via protecting MSCs against reactive oxygen species microenvironment by Nrf2/TXNIP/NLRP3 axis
In this study, a kartogenin (KGN)@PLGA-GelMA/PRP composite hydrogel was designed and used as a carrier of ADSCs-based therapies in disc repair. Injectable composite hydrogel act as a carrier for controlled release of KGN and deliver ADSCs to the degenerative disc. The released KGN can stimulate the differentiation of ADSCs into a nucleus pulposus (NP) -like phenotype and boost antioxidant capacity of ADSCs via activating Nrf2/TXNIP/NLRP3 axis. Furthermore, the composite hydrogel combined with ADSCs attenuated the in vivo degeneration of rat IVDs, maintained IVD tissue integrity and accelerated the synthesis of NP-like extr...
Source: Free Radical Biology and Medicine - May 6, 2023 Category: Biology Authors: Feng Wang Kai Guo Liping Nan Shuguang Wang Jiawei Lu Qiang Wang Zhaoyu Ba Yufeng Huang Desheng Wu Source Type: research
Fight Aging! Newsletter, May 1st 2023
In conclusion, frailty progression accelerates in males with one LTCs and females with two LTCs or more. Health providers should be aware of planning a suitable intervention once the elderly have two or more health conditions.
Plasma Transfer Lowers Epigenetic Age and Mortality in Rats
https://www.fightaging.org/archives/2023/04/plasma-transfer-lowers-epigenetic-age-and-mortality-in-rats/
Plasma transfer from young to old individuals has produced mixed results in animals and little to no benefit in humans where assessed rigorously. These studies were driven by the hypothesis that young plasma contains me...
Source: Fight Aging! - April 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Enhancement of mesenchymal stem cells' chondrogenic potential by type II collagen-based bioscaffolds
CONCLUSIONS: Our data support that type II collagen contributes as a natural bioscaffold enhancing chondrogenesis in both MSC models, thus enhancing the commitment of MSC-based therapeutic approaches in regenerative medicine to target OA and bring therapy closer to the clinical use.PMID:37118382 | DOI:10.1007/s11033-023-08461-x
Source: Molecular Biology Reports - April 28, 2023 Category: Molecular Biology Authors: Zoi Piperigkou Dimitra Bainantzou Nadia Makri Eleni Papachristou Aglaia Mantsou Theodora Choli-Papadopoulou Achilleas D Theocharis Nikos K Karamanos Source Type: research
