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Therapy: Stem Cell Therapy
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Total 3267 results found since Jan 2013.
What is the optimal dose of adipose-derived mesenchymal stem cells treatment for knee osteoarthritis? A conventional and network meta-analysis of randomized controlled trials
CONCLUSIONS: Both cell doses reduced pain and improved knee function in KOA patients. The effect surpassed in the high-dose group than in the moderate-dose, low-dose and control groups. However, adverse events also increase with the increase in dose, which should be carefully considered in clinical application, and the side effects still need to be paid attention to. Considering the limitations of this meta-analysis, future studies need to further explore the efficacy and safety of different doses of treatment, and carry out large sample, multi-center, randomized controlled trials to ensure the reliability and promotion va...
Source: Cell Research - September 12, 2023 Category: Cytology Authors: Zongyuan Huang Shuai Zhang Mingde Cao Zhujian Lin Ling Kong Xin Wu Qianshi Guo Yuxiang Ouyang Yancheng Song Source Type: research
Lgr5-expressing secretory cells form a Wnt inhibitory niche in cartilage critical for chondrocyte identity
Cell Stem Cell. 2023 Sep 7;30(9):1179-1198.e7. doi: 10.1016/j.stem.2023.08.004.ABSTRACTOsteoarthritis is a degenerative joint disease that causes pain, degradation, and dysfunction. Excessive canonical Wnt signaling in osteoarthritis contributes to chondrocyte phenotypic instability and loss of cartilage homeostasis; however, the regulatory niche is unknown. Using the temporomandibular joint as a model in multiple species, we identify Lgr5-expressing secretory cells as forming a Wnt inhibitory niche that instruct Wnt-inactive chondroprogenitors to form the nascent synovial joint and regulate chondrocyte lineage and identit...
Source: Cell Stem Cell - September 8, 2023 Category: Stem Cells Authors: Angela Ruscitto Peng Chen Ikue Tosa Ziyi Wang Gan Zhou Ingrid Safina Ran Wei Mallory M Morel Alia Koch Michael Forman Gwendolyn Reeve Michael K Lecholop Marshall Wilson Daniel Bonthius Mo Chen Mitsuaki Ono Timothy C Wang Hai Yao Mildred C Embree Source Type: research
The clinical outcomes of intra-articular injection of human umbilical cord blood-derived mesenchymal stem cells vs. bone marrow aspirate concentrate in cartilage regeneration: a systematic review
CONCLUSIONS: This systematic review presents evidence that compared with BMAC injection, intra-articular hUCB-MSCs can induce significantly better tissue repair at 1 year after surgery, as assessed by the ICRS grade. Although there is only short-term follow-up evidence and a lack of histochemical evidence, our systematic review supports the recommendation to use hUCB-MSCs as the source of pluripotent stem cells for treating ICRS III cartilage lesions.PMID:37667930 | DOI:10.26355/eurrev_202308_33405
Source: European Review for Medical and Pharmacological Sciences - September 5, 2023 Category: Drugs & Pharmacology Authors: P-F Wang J Xing Source Type: research
Mesenchymal stem cell licensing: enhancing MSC function as a translational approach for the treatment of tendon injury
This article details current evidence on the effects of licensed MSCs in both in vitro and in vivo disease models of different species and provides commentary on how those effector functions identified may be translated to the treatment of tendon injuries.PMID:37669745 | DOI:10.2460/ajvr.23.07.0154
Source: American Journal of Veterinary Research - September 5, 2023 Category: Veterinary Research Authors: Drew W Koch Lauren V Schnabel Source Type: research
The clinical outcomes of intra-articular injection of human umbilical cord blood-derived mesenchymal stem cells vs. bone marrow aspirate concentrate in cartilage regeneration: a systematic review
CONCLUSIONS: This systematic review presents evidence that compared with BMAC injection, intra-articular hUCB-MSCs can induce significantly better tissue repair at 1 year after surgery, as assessed by the ICRS grade. Although there is only short-term follow-up evidence and a lack of histochemical evidence, our systematic review supports the recommendation to use hUCB-MSCs as the source of pluripotent stem cells for treating ICRS III cartilage lesions.PMID:37667930 | DOI:10.26355/eurrev_202308_33405
Source: Pharmacological Reviews - September 5, 2023 Category: Drugs & Pharmacology Authors: P-F Wang J Xing Source Type: research
Hypoxia-treated adipose mesenchymal stem cell-derived exosomes attenuate lumbar facet joint osteoarthritis
CONCLUSIONS: Our results show that hypoxia is an effective method to improve the therapeutic effect of ADSC-Exos on ameliorating spinal pain and LFJ OA progression.PMID:37670256 | DOI:10.1186/s10020-023-00709-3
Source: Molecular Medicine - September 5, 2023 Category: Molecular Biology Authors: Jinyun Zhao Yi Sun Xiaolong Sheng Jiaqi Xu Guoyu Dai Rundong He Yuxin Jin Zhide Liu Yong Xie Tianding Wu Yong Cao Jianzhong Hu Chunyue Duan Source Type: research
Mesenchymal stem cell licensing: enhancing MSC function as a translational approach for the treatment of tendon injury
This article details current evidence on the effects of licensed MSCs in both in vitro and in vivo disease models of different species and provides commentary on how those effector functions identified may be translated to the treatment of tendon injuries.PMID:37669745 | DOI:10.2460/ajvr.23.07.0154
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Drew W Koch Lauren V Schnabel Source Type: research
