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Total 12483 results found since Jan 2013.
Effect of definitive hypo-fractionated radiotherapy concurrent with weekly cisplatin in locally advanced squamous cell carcinoma of the head and neck
In this study, we aimed to determine whether hypo-fractionated intensity-modulated radiotherapy (hypo-IMRT) with concurrent chemotherapy was practical, effective, and could achieve acceptable tumor control rates for squamous cell carcinoma of the head and neck (SCCHN). We enrolled 62 patients with high-risk stage II, stage III, and IVA SCCHN who received hypo-IMRT (62.5 Gy in 25 fractions over 5 weeks 2.5Gy/fraction with weekly cisplatin 40 mg/m2). Our primary endpoint was to assess acute toxicity, while our secondary endpoints were late toxicity, loco-regional control, disease-free survival, and overall survival. The perc...
Source: Journal of Medicine and Life - July 31, 2023 Category: General Medicine Authors: Nora Abdelhafiz Doaa Mahmoud Mohamed Gad Hoda Essa Aiat Morsy Source Type: research
Efficacy of metformin in prevention of paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled trial
Conclusion: The use of metformin in breast cancer patients offered a marked protection against paclitaxel-induced PN, which translated to better patient QoL.Clinical Trial Registration: https://classic.clinicaltrials.gov/ct2/show/NCT05351021, identifier NCT05351021.
Source: Frontiers in Pharmacology - July 31, 2023 Category: Drugs & Pharmacology Source Type: research
Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity.
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Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Safety and Efficacy of Oxaliplatin Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC) in Colorectal and Appendiceal Cancer with Peritoneal Metastases: Results of a Multicenter Phase I Trial in the USA
CONCLUSIONS: This phase I trial in the USA demonstrated safety, feasibility, and early efficacy signal of PIPAC with oxaliplatin and chemotherapy in patients with PM from AC or CRC who are refractory to standard lines of systemic chemotherapy.PMID:37501051 | DOI:10.1245/s10434-023-13941-2
Source: Ann Oncol - July 27, 2023 Category: Cancer & Oncology Authors: Mustafa Raoof Richard L Whelan Kevin M Sullivan Christopher Ruel Paul H Frankel Sarah E Cole Raechelle Tinsley Melissa Eng Marwan Fakih Joseph Chao Dean Lim Yanghee Woo Isaac Benjamin Paz Michael Lew Michaela Cristea Lorna Rodriguez-Rodriguez Yuman Fong R Source Type: research
A Case of Histologically Proven Recurrent Synovitis after Nivolumab Treatment
Intern Med. 2023 Jul 26. doi: 10.2169/internalmedicine.2221-23. Online ahead of print.ABSTRACTA 58-year-old woman with rheumatoid arthritis was diagnosed with methotrexate-associated Hodgkin lymphoma. After receiving several chemotherapy regimens, she started nivolumab treatment. Two weeks later, she was hospitalized with worsening finger, wrist, and elbow joint pain. A synovial biopsy of the wrist joint showed villous synovial proliferation and linear infiltration of CD68-/CD3-positive T cells (with more CD8 than CD4 T cells) but no CD20-positive B cells or CD138-positive macrophages. These findings corresponded to synovi...
Source: Internal Medicine - July 26, 2023 Category: Internal Medicine Authors: Yuki Nakayama Naoki Sawa Tatsuya Suwabe Masayuki Yamanouchi Daisuke Ikuma Hiroki Mizuno Eiko Hasegawa Akinari Sekine Yuki Oba Kazuya Ishiwata Atsushi Wake Masaki Hatano Izuru Kitajima Kei Kono Keiichi Kinowaki Yutaka Takazawa Tamiko Takemura Yoshifumi Uba Source Type: research
