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Surgical treatment of < em > Candida albicans < /em > spondylodiscitis
CONCLUSION: In summary, evaluation for fungal infection is essential in all cases of unexplained spinal infection in immunocompromised patients, regardless of presentation. If the antifungal treatment proves ineffective, a surgical approach is typically employed for the management of fungal spondylodiscitis. Our report details a successful case of fungal spondylodiscitis treated with a surgical approach and highlights the potential for a fungal infection to be a causative factor in noncompressive myelopathy, which may be sometimes mistaken for radiation myelitis.PMID:37663715 | PMC:PMC10473295 | DOI:10.1097/MS9.0000000000001114
Source: Annals of Medicine - September 4, 2023 Category: Internal Medicine Authors: Prashant Adhikari Nishma Pokharel Sulochana Khadka Ishwar Lohani Prakash Kafle Sandeep Bhandari Bhaskar Raj Pant Pradeep Raj Regmi Emre Acaro ğlu Source Type: research
Osteolytic bone lesions as an initial presenting manifestation of adult acute lymphoblastic leukemia: a mini review
Ann Med Surg (Lond). 2023 Jul 20;85(9):4404-4409. doi: 10.1097/MS9.0000000000001065. eCollection 2023 Sep.ABSTRACTHematological malignancies can lead to bone lesions, and the most common example is the osteolytic lesions found in multiple myeloma. Cases of osteolytic lesions have been rarely reported in acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma, Waldenström macroglobulinemia, chronic lymphocytic leukemia, acute myeloid leukemia, and myeloproliferative neoplasms. This review sheds light on the association between ALL and osteolytic bone lesions. To our knowledge, we found 15 cases of patients with ALL who de...
Source: Annals of Medicine - September 4, 2023 Category: Internal Medicine Authors: Abdulrahman F Al-Mashdali Hussam N Al-Dubai Mohamed A Yassin Source Type: research
Surgical treatment of < em > Candida albicans < /em > spondylodiscitis
CONCLUSION: In summary, evaluation for fungal infection is essential in all cases of unexplained spinal infection in immunocompromised patients, regardless of presentation. If the antifungal treatment proves ineffective, a surgical approach is typically employed for the management of fungal spondylodiscitis. Our report details a successful case of fungal spondylodiscitis treated with a surgical approach and highlights the potential for a fungal infection to be a causative factor in noncompressive myelopathy, which may be sometimes mistaken for radiation myelitis.PMID:37663715 | PMC:PMC10473295 | DOI:10.1097/MS9.0000000000001114
Source: Annals of Medicine - September 4, 2023 Category: Internal Medicine Authors: Prashant Adhikari Nishma Pokharel Sulochana Khadka Ishwar Lohani Prakash Kafle Sandeep Bhandari Bhaskar Raj Pant Pradeep Raj Regmi Emre Acaro ğlu Source Type: research
Transcriptome Profiling of miRNA-mRNA Interactions and Associated Mechanisms in Chemotherapy-Induced Neuropathic Pain
AbstractChemotherapy-induced neuropathic pain (CINP) is a dose-limiting adverse event affecting 40% of chemotherapy patients. MiRNA-mRNA interaction plays an important role in various processes. However, detailed profiling of miRNA-mRNA interactions in CINP remains unclear. Here, a rat-based CINP model was established using paclitaxel, followed by nociceptive behavioral tests related to mechanical allodynia, thermal hyperalgesia, and cold allodynia. The landscape of miRNA-mRNA interaction in the spinal dorsal horn was investigated through mRNA transcriptomics and small RNA sequencing. Under CINP condition, 86 differentiall...
Source: Molecular Neurobiology - September 1, 2023 Category: Neurology Source Type: research
The Long-Term and Late Effects of the Diagnosis and Treatment of Colorectal Cancer
CONCLUSION: Insight gained into long-term and late effects and their treatment, indicated that many participants suffered because of their after-effects and had unmet health needs. It adds a qualitative insight into an area where quantitative research has already been conducted. Improvements in cancer follow-up could offer opportunities to effectively identify, manage and monitor these effects. Further interventional studies are required to develop effective care pathways to achieve optimal care.PMID:37649914 | PMC:PMC10464626
Source: The Ulster Medical Journal - August 31, 2023 Category: General Medicine Authors: Andrew Carlile Tim McAdam Source Type: research
Interventions for the treatment of oral cavity and oropharyngeal cancers: surgical treatment
CONCLUSIONS: We found moderate-certainty evidence based on five trials that elective neck dissection of clinically negative neck nodes at the time of removal of the primary oral cavity tumour is superior to therapeutic neck dissection, with increased survival and disease-free survival, and reduced locoregional recurrence. There was moderate-certainty evidence from one trial of no difference between positron emission tomography (PET-CT) following chemoradiotherapy versus planned neck dissection in terms of overall survival or locoregional recurrence. The evidence for each of the other seven comparisons came from only one or...
Source: Cochrane Database of Systematic Reviews - August 31, 2023 Category: General Medicine Authors: Helen V Worthington Vishal M Bulsara Anne-Marie Glenny Janet E Clarkson David I Conway Michaelina Macluskey Source Type: research
The Long-Term and Late Effects of the Diagnosis and Treatment of Colorectal Cancer
CONCLUSION: Insight gained into long-term and late effects and their treatment, indicated that many participants suffered because of their after-effects and had unmet health needs. It adds a qualitative insight into an area where quantitative research has already been conducted. Improvements in cancer follow-up could offer opportunities to effectively identify, manage and monitor these effects. Further interventional studies are required to develop effective care pathways to achieve optimal care.PMID:37649914 | PMC:PMC10464626
Source: The Ulster Medical Journal - August 31, 2023 Category: General Medicine Authors: Andrew Carlile Tim McAdam Source Type: research
