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Neuroblastoma of the lumbosacral canal in an adult: a case report and literature review
Neuroblastoma (NB) is a leading cause of death in children. It usually occurs in the adrenal gland and rarely in the spinal canal. Here, we report the case of a 48-year-old male patient with abnormal thickening of the cauda equina nerve as revealed by lumbosacral magnetic resonance imaging. The patient’s main clinical manifestations were numbness and pain in both lower limbs. The patient underwent surgical treatment; however, intraoperatively, an unclear border was observed between the cauda equina nerve and the tumor; therefore, the tumor was not forcibly excised. The postoperative pathological results were reported as ...
Source: Frontiers in Neurology - August 3, 2023 Category: Neurology Source Type: research
Chemotherapy-induced toxic epidermal necrolysis in a patient with multiple myeloma, a case report and literature review
Rationale and patient concernsToxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are severe drug-induced skin reactions associated with a high mortality rate. The patient in this case report developed TEN after receiving the Velcade-lenalidomide-dexamethasone (VRD) regimen for the treatment of multiple myeloma (MM). The patient’s concerns included the progression of the rash, pain, itching, and potential long-term complications. TEN is a life-threatening condition that requires prompt medical intervention and hospitalization.InterventionsThe treatment approach for the patient included discontinuation of ...
Source: Frontiers in Oncology - August 2, 2023 Category: Cancer & Oncology Source Type: research
Morphine decreases cytotoxicity and mutagenicity of doxorubicin in vitro: Implications for cancer chemotherapy
In conclusion, morphine decreased Dox cytotoxicity in both neuronal and non-neuronal cells and showed antimutagenic effects in the TA102 strain which detects mutagens inducing DNA oxidative damages. However, morphine decreased frameshift mutations induced by Dox in non-cytotoxic concentrations, an effect suggesting interference of Dox intercalation activity that could decrease its chemotherapeutic efficacy. These compelling findings highlight the importance of conducting further studies to explore the potential implications of co-administering morphine and Dox during cancer chemotherapy.PMID:37524295 | DOI:10.1016/j.cbi.2023.110652
Source: Chemico-Biological Interactions - July 31, 2023 Category: Molecular Biology Authors: Jayne Torres de Sousa Rafael Rodrigues Dihl Fernanda Bri ão Menezes Boaretto Ana Leticia Hil ário Garcia Ivana Grivicich Juliana da Silva Jaqueline Nascimento Picada Source Type: research
Effect of definitive hypo-fractionated radiotherapy concurrent with weekly cisplatin in locally advanced squamous cell carcinoma of the head and neck
In this study, we aimed to determine whether hypo-fractionated intensity-modulated radiotherapy (hypo-IMRT) with concurrent chemotherapy was practical, effective, and could achieve acceptable tumor control rates for squamous cell carcinoma of the head and neck (SCCHN). We enrolled 62 patients with high-risk stage II, stage III, and IVA SCCHN who received hypo-IMRT (62.5 Gy in 25 fractions over 5 weeks 2.5Gy/fraction with weekly cisplatin 40 mg/m2). Our primary endpoint was to assess acute toxicity, while our secondary endpoints were late toxicity, loco-regional control, disease-free survival, and overall survival. The perc...
Source: Journal of Medicine and Life - July 31, 2023 Category: General Medicine Authors: Nora Abdelhafiz Doaa Mahmoud Mohamed Gad Hoda Essa Aiat Morsy Source Type: research
Morphine decreases cytotoxicity and mutagenicity of doxorubicin in vitro: Implications for cancer chemotherapy
In conclusion, morphine decreased Dox cytotoxicity in both neuronal and non-neuronal cells and showed antimutagenic effects in the TA102 strain which detects mutagens inducing DNA oxidative damages. However, morphine decreased frameshift mutations induced by Dox in non-cytotoxic concentrations, an effect suggesting interference of Dox intercalation activity that could decrease its chemotherapeutic efficacy. These compelling findings highlight the importance of conducting further studies to explore the potential implications of co-administering morphine and Dox during cancer chemotherapy.PMID:37524295 | DOI:10.1016/j.cbi.2023.110652
Source: Chemico-Biological Interactions - July 31, 2023 Category: Molecular Biology Authors: Jayne Torres de Sousa Rafael Rodrigues Dihl Fernanda Bri ão Menezes Boaretto Ana Leticia Hil ário Garcia Ivana Grivicich Juliana da Silva Jaqueline Nascimento Picada Source Type: research
Effect of definitive hypo-fractionated radiotherapy concurrent with weekly cisplatin in locally advanced squamous cell carcinoma of the head and neck
In this study, we aimed to determine whether hypo-fractionated intensity-modulated radiotherapy (hypo-IMRT) with concurrent chemotherapy was practical, effective, and could achieve acceptable tumor control rates for squamous cell carcinoma of the head and neck (SCCHN). We enrolled 62 patients with high-risk stage II, stage III, and IVA SCCHN who received hypo-IMRT (62.5 Gy in 25 fractions over 5 weeks 2.5Gy/fraction with weekly cisplatin 40 mg/m2). Our primary endpoint was to assess acute toxicity, while our secondary endpoints were late toxicity, loco-regional control, disease-free survival, and overall survival. The perc...
Source: Journal of Medicine and Life - July 31, 2023 Category: General Medicine Authors: Nora Abdelhafiz Doaa Mahmoud Mohamed Gad Hoda Essa Aiat Morsy Source Type: research
Morphine decreases cytotoxicity and mutagenicity of doxorubicin in vitro: Implications for cancer chemotherapy
In conclusion, morphine decreased Dox cytotoxicity in both neuronal and non-neuronal cells and showed antimutagenic effects in the TA102 strain which detects mutagens inducing DNA oxidative damages. However, morphine decreased frameshift mutations induced by Dox in non-cytotoxic concentrations, an effect suggesting interference of Dox intercalation activity that could decrease its chemotherapeutic efficacy. These compelling findings highlight the importance of conducting further studies to explore the potential implications of co-administering morphine and Dox during cancer chemotherapy.PMID:37524295 | DOI:10.1016/j.cbi.2023.110652
Source: Chemico-Biological Interactions - July 31, 2023 Category: Molecular Biology Authors: Jayne Torres de Sousa Rafael Rodrigues Dihl Fernanda Bri ão Menezes Boaretto Ana Leticia Hil ário Garcia Ivana Grivicich Juliana da Silva Jaqueline Nascimento Picada Source Type: research
Effectiveness of physiotherapy interventions on improving quality of life, total neuropathy score, strength and reducing pain in cancer survivors suffering from chemotherapy-induced peripheral neuropathy - a systematic review
CONCLUSIONS: Physical therapy has additional benefits for enhancing the quality of life of patients with peripheral neuropathy brought on by chemotherapy.PMID:37522184 | DOI:10.1080/0284186X.2023.2238890
Source: Acta Oncologica - July 31, 2023 Category: Cancer & Oncology Authors: Nikita H Seth Irshad Qureshi Source Type: research
Effect of definitive hypo-fractionated radiotherapy concurrent with weekly cisplatin in locally advanced squamous cell carcinoma of the head and neck
In this study, we aimed to determine whether hypo-fractionated intensity-modulated radiotherapy (hypo-IMRT) with concurrent chemotherapy was practical, effective, and could achieve acceptable tumor control rates for squamous cell carcinoma of the head and neck (SCCHN). We enrolled 62 patients with high-risk stage II, stage III, and IVA SCCHN who received hypo-IMRT (62.5 Gy in 25 fractions over 5 weeks 2.5Gy/fraction with weekly cisplatin 40 mg/m2). Our primary endpoint was to assess acute toxicity, while our secondary endpoints were late toxicity, loco-regional control, disease-free survival, and overall survival. The perc...
Source: Journal of Medicine and Life - July 31, 2023 Category: General Medicine Authors: Nora Abdelhafiz Doaa Mahmoud Mohamed Gad Hoda Essa Aiat Morsy Source Type: research
Effectiveness of physiotherapy interventions on improving quality of life, total neuropathy score, strength and reducing pain in cancer survivors suffering from chemotherapy-induced peripheral neuropathy - a systematic review
CONCLUSIONS: Physical therapy has additional benefits for enhancing the quality of life of patients with peripheral neuropathy brought on by chemotherapy.PMID:37522184 | DOI:10.1080/0284186X.2023.2238890
Source: Acta Oncologica - July 31, 2023 Category: Cancer & Oncology Authors: Nikita H Seth Irshad Qureshi Source Type: research
Effect of definitive hypo-fractionated radiotherapy concurrent with weekly cisplatin in locally advanced squamous cell carcinoma of the head and neck
In this study, we aimed to determine whether hypo-fractionated intensity-modulated radiotherapy (hypo-IMRT) with concurrent chemotherapy was practical, effective, and could achieve acceptable tumor control rates for squamous cell carcinoma of the head and neck (SCCHN). We enrolled 62 patients with high-risk stage II, stage III, and IVA SCCHN who received hypo-IMRT (62.5 Gy in 25 fractions over 5 weeks 2.5Gy/fraction with weekly cisplatin 40 mg/m2). Our primary endpoint was to assess acute toxicity, while our secondary endpoints were late toxicity, loco-regional control, disease-free survival, and overall survival. The perc...
Source: Journal of Medicine and Life - July 31, 2023 Category: General Medicine Authors: Nora Abdelhafiz Doaa Mahmoud Mohamed Gad Hoda Essa Aiat Morsy Source Type: research
