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Total 180 results found since Jan 2013.

Evaluation of Bone Marrow Adipose Tissue and Bone Mineralization on Broiler Chickens Affected by Wooden Breast Myopathy
In humans, alterations in bone metabolism have been associated with myopathies. We postulate the hypothesis that perhaps similar pathologies can also be associated with modern chickens. Hence, this study aimed to assess the fat infiltration in bone marrow and its repercussion on broiler chicken affected by Wooden Breast (WB) myopathy. Ten Cobb 500 live birds with extreme rigidity of the Pectoralis major (PM) muscle were selected as WB affected chickens by physical examination of the muscle at 49 days of age, whereas ten chickens healthy with no physical signs of hardness in the breast muscle were considered to be unaffecte...
Source: Frontiers in Physiology - May 28, 2019 Category: Physiology Source Type: research

Neuromuscular and Muscle Metabolic Functions in MELAS Before and After Resistance Training: A Case Study
Conclusion To conclude, this study suggests a preserved plasticity in the skeletal muscle of a patient with MELAS. More importantly, Resistance Training appears to be a safe and effective method to increase skeletal muscle function in this patient population, and this effect is mediated by both neuromuscular and mitochondrial adaptations. However, particular attention and caution is needed in the interpretation of the data of this single case study and further studies are warranted including larger sample of patients. Ethics Statement For this case study the participant caregiver provided written informed consent. Auth...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Cellular and molecular signatures of alcohol-induced myopathy in women.
Abstract Alcoholic myopathy is characterized by the reduction in cross-sectional area (CSA) of muscle fibers and impaired anabolic signaling. The goal of the current study was to investigate the causes and compare the changes in CSA and fiber type composition with the modifications of anabolic and catabolic signaling pathways at the early stages of chronic alcohol consumption in women.Skeletal muscle samples from 5 female patients with alcohol abuse (AL; 43 ± 5 years old; alcohol abuse duration 5,6±0,6 years) were compared with the muscle from the control group of 8 healthy women (C; 35±4 years old). The averag...
Source: American Journal of Physiology. Endocrinology and Metabolism - March 25, 2019 Category: Physiology Authors: Shenkman BS, Zinovyeva OE, Belova SP, Mirzoev TM, Vilchinskaya NA, Vikhlyantsev IM, Ulanova AD, Turtikova O, Samkhaeva ND, Parfenov VA, Barinov AN, Nemirovskaya TL Tags: Am J Physiol Endocrinol Metab Source Type: research

Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle.
Abstract An impaired capacity of muscle to regenerate after critical illness results in long-term functional disability. We previously described in a long-term rat peritonitis model that gastrocnemius displays near-normal histology whereas soleus demonstrates a necrotizing phenotype. We thus investigated the link between the necrotizing phenotype of critical illness myopathy and proteasome activity in these two limb muscles. We studied male Wistar rats that underwent an intraperitoneal injection of the fungal cell wall constituent, zymosan, or n-saline as a sham-treated control. Rats (n=74) were killed at 2, 7, an...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 21, 2019 Category: Physiology Authors: Preau S, Ambler M, Sigurta A, Kleyman A, Dyson A, Hill NE, Boulanger E, Singer M Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Chronic exercise mitigates disease mechanisms and improves muscle function in myotonic dystrophy type 1 mice.
This article is protected by copyright. All rights reserved. PMID: 30628727 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - January 10, 2019 Category: Physiology Authors: Manta A, Stouth DW, Xhuti D, Chi L, Rebalka IA, Kalmar JM, Hawke TJ, Ljubicic V Tags: J Physiol Source Type: research

Molecular Consequences of the Myopathy-Related D286G Mutation on Actin Function
Jun Fan, Chun Chan, Elyshia L. McNamara, Kristen J. Nowak, Hiroyuki Iwamoto, Julien Ochala
Source: Frontiers in Physiology - December 4, 2018 Category: Physiology Source Type: research

Lipin1 is required for skeletal muscle development by regulating MEF2c and MyoD expression.
This study using cell type-specific Myf5-cre;Lipin1fl/fl conditional knockout mice (Lipin1Myf5cKO ) shows that lipin1 is a major determinant of SM development. Lipin1 deficiency induced reduced muscle mass and myopathy. Our results from lipin1-deficient myoblasts suggested that lipin1 regulates myoblast differentiation through the protein kinase Cμ (PKCμ)/histone deacetylase 5 (HDAC5)/myocyte-specific enhancer factor 2C (MEF2c):MyoD-mediated pathway. Lipin1 deficiency leads to the suppression of PKC isoform activities, as well as the inhibition of the downstream target of PKCμ, class II deacetylase HDAC5 nuclear export,...
Source: The Journal of Physiology - December 4, 2018 Category: Physiology Authors: Jama A, Huang D, Alshudukhi AAA, Chrast R, Ren H Tags: J Physiol Source Type: research

Lack of sexual dimorphism on the inhibitory effect of alcohol on muscle protein synthesis in rats under basal conditions and after anabolic stimulation
These data demonstrate that muscle protein synthesis does not vary with different phases of the estrus cycle and that there is no sexual dimorphism related to the inhibitory effect of alcohol on protein synthesis in rats under basal conditions and after anabolic stimulation. As alcohol ‐induced skeletal muscle myopathy is clinically relevant in both men and women, and the current data indicate no marked sex differences in MPS, there is strong justification for the inclusion of both male and female rats in future studies examining the underlying mechanisms. AbstractPrevious studies indicate women have a higher blood alcoh...
Source: Physiological Reports - December 4, 2018 Category: Physiology Authors: Charles H. Lang Tags: Original Research Source Type: research

Critical illness myopathy: Glucocorticoids revisited?
Acta Physiologica, EarlyView.
Source: Acta Physiologica - November 3, 2018 Category: Physiology Authors: Werner J. Z ’Graggen, Joerg C. Schefold Source Type: research

ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain.
This article is protected by copyright. All rights reserved. PMID: 30382595 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - November 1, 2018 Category: Physiology Authors: Bulla M, Gyimesi G, Kim JH, Bhardwaj R, Hediger MA, Frieden M, Demaurex N Tags: J Physiol Source Type: research

Editorial: Critical Illness Myopathy: Glucocorticoids revisited?
Acta Physiologica,Volume 0, Issue ja, -Not available-.
Source: Acta Physiologica - October 19, 2018 Category: Physiology Authors: Werner J. Z'Graggen, Joerg C. Schefold Source Type: research

Vamorolone Treatment Improves Skeletal Muscle Outcome in a Critical Illness Myopathy Rat Model
Acta Physiologica,Volume 0, Issue ja, -Not available-.
Source: Acta Physiologica - August 18, 2018 Category: Physiology Authors: Hazem Akkad , Nicola Cacciani , Monica Llano ‐Diez , Rebeca Corpeno Kalamgi , Tamara Tchkonia , James L. Kirkland , Lars Larsson Source Type: research

Green tea epigallocatechin gallate enhances cardiac function restoration through survival signaling expression in diabetes mellitus rats with autologous adipose tissue-derived stem cells
The present study tests a hypothesis that cardioprotective effects mediated by autologous adipose-derived stem cells (ADSC) in rats afflicted with insulin-dependent diabetes mellitus (IDDM) may be synergistically enhanced by oral treatment with green tea epigallocatechin gallate (EGCG). Wistar rats were divided into sham, DM, DM+ADSC (autologous transplanted 1 x 106 cells per rat), and DM+ADSC+E (E, green tea oral administration EGCG). Heart tissues were isolated from all rats, and investigations were performed after 2-mo treatment. In the sham, DM, and DM+ADSC groups, we found that DM induced cardiac dysfunction (sham and...
Source: Journal of Applied Physiology - November 2, 2017 Category: Physiology Authors: Chen, T.-S., Liou, S.-Y., Kuo, C.-H., Pan, L.-F., Yeh, Y.-L., Liou, J., Padma, V. V., Yao, C.-H., Kuo, W.-W., Huang, C.-Y. Tags: RESEARCH ARTICLE Source Type: research

Impaired excitation-contraction coupling in muscle fibres from the dynamin2(R465W) mouse model of centronuclear myopathy.
This article is protected by copyright. All rights reserved. PMID: 29071728 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - October 26, 2017 Category: Physiology Authors: Kutchukian C, Szentesi P, Allard B, Trochet D, Beuvin M, Berthier C, Tourneur Y, Guicheney P, Csernoch L, Bitoun M, Jacquemond V Tags: J Physiol Source Type: research