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IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research
