Filtered By:
Specialty: Physiology
This page shows you your search results in order of date. This is page number 6.
Order by Relevance | Date
Total 180 results found since Jan 2013.
IL-6 production of C2C12 cells is enhanced in the presence of macrophages and pravastatin
Gen Physiol Biophys. 2021 Jul;40(4):307-315. doi: 10.4149/gpb_2021017.ABSTRACTSkeletal muscle secrets several bioactive molecules known as myokines. Interleukin-6 (IL-6) has been described as a myokine secreted in response to skeletal muscle injury as well as to macrophage invasion in inflammation. To our knowledge no connection between macrophages and skeletal muscle regarding IL-6 secretion has been described so far. Here we report that co-culturing of C2C12 cells with RAW macrophages enhances IL-6 secretion of the cells cultured together. However, this is not seen in cross-feeding experiments, where culture medium of RA...
Source: General Physiology and Biophysics - August 5, 2021 Category: Physiology Authors: Karolina Cseri P éter Szentesi L ászló Csernoch Source Type: research
The impact of hindlimb disuse on sepsis ‐induced myopathy in mice
This study shows the impact of skeletal muscle disuse on sepsis-induced myopathy in mice. Developed with Biorender software. AbstractSepsis induces a myopathy characterized by loss of muscle mass and weakness. Septic patients undergo prolonged periods of limb muscle disuse due to bed rest. The contribution of limb muscle disuse to the myopathy phenotype remains poorly described. To characterize sepsis-induced myopathy with hindlimb disuse, we combined the classic sepsis model via cecal ligation and puncture (CLP) with the disuse model of hindlimb suspension (HLS) in mice. Male C57bl/6j mice underwent CLP or SHAM surgeries....
Source: Physiological Reports - July 27, 2021 Category: Physiology Authors: Orlando Laitano,
Jose Pindado,
Isela Valera,
Ray A. Spradlin,
Kevin O. Murray,
Katelyn R. Villani,
Jamal M. Alzahrani,
Terence E. Ryan,
Philip A. Efron,
Leonardo F. Ferreira,
Elisabeth R. Barton,
Thomas L. Clanton Tags: ORIGINAL ARTICLE Source Type: research
Differential Expression of Myogenic and Calcium Signaling-Related Genes in Broilers Affected With White Striping
White Striping (WS) has been one of the main issues in poultry production in the last years since it affects meat quality. Studies have been conducted to understand WS and other myopathies in chickens, and some biological pathways have been associated to the prevalence of these conditions, such as extracellular calcium level, oxidative stress, localized hypoxia, possible fiber-type switching, and cellular repairing. Therefore, to understand the genetic mechanisms involved in WS, 15 functional candidate genes were chosen to be analyzed by quantitative PCR (qPCR) in breast muscle of normal and WS-affected chickens. To this, ...
Source: Frontiers in Physiology - July 26, 2021 Category: Physiology Source Type: research
Blood Plasma Biomarkers for Woody Breast Disease in Commercial Broilers
Woody breast (WB) myopathy results in poor muscle quality. The increasing incidence of WB over the last several years indicates a need for improved prediction or early diagnosis. We hypothesized that the use of body fluids, including blood, may be more suitable than breast muscle tissue in developing a minimally invasive diagnostic tool for WB detection. To identify potential early-age-biomarkers that may represent the potential onset of WB, blood samples were collected from 100, 4 wks old commercial male broilers. At 8 wks of age, WB conditions were scored by manual palpation. A total of 32 blood plasma samples (eight for...
Source: Frontiers in Physiology - July 22, 2021 Category: Physiology Source Type: research
Insights Into Transcriptome Profiles Associated With Wooden Breast Myopathy in Broilers Slaughtered at the Age of 6 or 7 Weeks
Transcriptomes associated with wooden breast (WB) were characterized in broilers at two different market ages. Breasts (Pectoralis major) were collected, 20-min postmortem, from male Ross 308 broilers slaughtered at 6 and 7 weeks of age. The breasts were classified as “non-WB” or “WB” based on palpation hardness scoring (non-WB = no abnormal hardness, WB = consistently hardened). Total RNA was isolated from 16 samples (n = 3 for 6 week non-WB, n = 3 for 6 week WB; n = 5 for 7 week non-WB, n = 5 for 7 week WB). Transcriptome was profiled using a chicken gene expression microarray with one-color hybridization techniq...
Source: Frontiers in Physiology - June 28, 2021 Category: Physiology Source Type: research
Skeletal myopathy in CKD: a comparison of adenine-induced nephropathy and 5/6 nephrectomy models in mice
The objective of the present study was to compare the adenine diet and 5/6 nephrectomy (5/6 Nx) models in mice. Male and female 10-week-old C57BL/6J mice (N=5-9/sex/group) were randomly allocated to CKD groups (0.2-0.15% adenine-supplemented diet or 5/6 Nx surgery) or corresponding control groups (casein diet or sham surgery). Glomerular filtration rate was reduced to a similar level in adenine and 5/6 Nx mice (adenine male: 81.1 ± 41.9 µL/min vs. 5/6 Nx male: 160 ± 80.9 µL/min, P=0.5875; adenine female: 112.9 ± 32.4 µL/min vs. 5/6 Nx female: 107.0 ± 45.7 µL/min, P=0.9995). Serum metabolomics analysis indicated tha...
Source: American Journal of Physiology. Renal Physiology - June 14, 2021 Category: Physiology Authors: Kyoungrae Kim Erik M Anderson Trace Thome Guanyi Lu Zachary R Salyers Tomas A Cort Kerri A O'Malley Salvatore T Scali Terence E Ryan Source Type: research
