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Total 174 results found since Jan 2013.

Axial muscle weakness and the rimmed vacuoles in muscle histology in inflammatory myopathy with anti-ku antibody: a case report
Scand J Rheumatol. 2021 May 5:1-3. doi: 10.1080/03009742.2021.1894825. Online ahead of print.NO ABSTRACTPMID:33949908 | DOI:10.1080/03009742.2021.1894825
Source: Scandinavian Journal of Rheumatology - May 5, 2021 Category: Rheumatology Authors: L Qiao R Ban Q Shi Source Type: research

P047  An unusual case of dermatomyositis with co-existent anti-GAD and anti-NXP2 antibody positivity
Conclusion GAD antibodies are known to be associated with many disorders including diabetes and stiff person syndrome and can recognise different epitopes in various diseases. This is the first documented case of GAD occurring in a DM patient, in the presence of NXP2 antibodies. IVIG is used to treat both s tiff man syndrome and refractory DM. It is possible that the combination of GAD and NXP2 contributed to the pathogenesis and severity of the clinical presentation in this case.Disclosure K. Beharry: None.G. Barminski: None.D. De Lord: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

P035  Inflammatory myopathy and metabolic disorders causing myopathies
Conclusion This lady was initially managed as inflammatory myopathy but did not respond to high dose methylprednisolone. There were atypical features including normal inflammatory markers, MRI thighs showing predominantly fatty infiltration and muscle atrophy and the muscle biopsy with abundant lipid accumu lation suggestive of a metabolic disorder. We are awaiting full results of genetic testing. This case is a reminder of the importance of tissue diagnosis and reassessing the initial diagnosis if the clinical picture changes or patients do not respond as expected to treatment.Disclosure M. Malik: None.A. Mason: None....
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Clinical Characteristics of Myositis Associated with Graft-Versus-Host Disease
AbstractPurpose of ReviewRecipients of allogeneic hematopoietic stem cell transplantation (HSCT) are at increased risk for inflammatory myositis; histological subsets reported include dermatomyositis, necrotising myopathy and chronic graft-versus-host disease (cGVHD) –related myositis. Though corticosteroids and various immunosuppressive therapies have been used, there is a lack of consensus guidelines dictating therapy.Recent FindingsRecent evidence suggests the fascia as a preferential target in cGVHD myositis, with conditioning regimens promoting fascial microtrauma. Positron emission tomography (PET) can be a useful ...
Source: Current Rheumatology Reports - April 24, 2021 Category: Rheumatology Source Type: research

Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1
CONCLUSION: Statin causes skeletal injury through induction of miR-1a excessive expression to decrease MAP3K1 gene expression.PMID:33864447 | DOI:10.18632/aging.202839
Source: Aging - April 17, 2021 Category: Biomedical Science Authors: Chang-Ning Fu Jia-Wen Song Zhi-Peng Song Qian-Wen Wang Wen-Wu Bai Tao Guo Peng Li Chao Liu Shuang-Xi Wang Bo Dong Source Type: research

Fatal interstitial lung disease and pneumocystis during dermatomyositis associated with anti-MDA5  antibodies.
DISCUSSION: Anti-MDA5 antibodies are associated with a specific clinical phenotype and a high degree of risk that should alert the dermatologist to the high likelihood of ILD having a poor prognosis. Associated clinical signs are erythematous, hyperkeratotic or ulcerated papules on the palm creases, as well as fingertip or periungual ulcerations or digital necrosis. This situation is associated with a high risk of pneumocystosis. However, no recommendations concerning prophylaxis are currently available. PMID: 33131899 [PubMed - as supplied by publisher]
Source: Annales de Dermatologie et de Cenereologie - October 29, 2020 Category: Dermatology Authors: Seiller H, Schmutz JL, Poreaux C, Bursztejn AC Tags: Ann Dermatol Venereol Source Type: research

A novel application of tau PET in the diagnosis of sporadic inclusion body myositis: A case report
We presented a 46-year-old woman who suffered from progressive lower limb weakness for one and a half year. Diagnoses: Needle electromyography showed myogenic damage. Characteristic myopathological changes of sIBM were discovered, and abnormal tau protein deposits were identified by tau immunostaining. Genetic testing ruled out the GNE myopathy, a hereditary distal myopathy with rimmed vacuoles. The patient was finally diagnosed as sIBM. Interventions: We performed [18F] THK5317 PET/MRI on the patient. Outcomes: There were significantly increased tau uptake levels in the quadriceps muscles of sIBM patient. The upt...
Source: Medicine - July 31, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Diagnostic Value of Muscle 11C PIB-PET in Inclusion Body Myositis
Conclusions: Muscle PIB-PET may help to make a diagnosis of s-IBM.
Source: Frontiers in Neurology - January 16, 2020 Category: Neurology Source Type: research

Anti-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibody in necrotizing myopathy: treatment outcomes, cancer risk, and role of autoantibody level.
Conclusion: HMGCR Ab-positive NM patients are associated with statin exposure, have severe muscle weakness and high CK at presentation, lack other organ manifestations, and generally have favourable outcomes from immunosuppression. Anti-HMGCR Abs should be assessed in MSA-negative NM patients, particularly those with a history of statin exposure. PMID: 31801390 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - December 4, 2019 Category: Rheumatology Authors: Aggarwal R, Moghadam-Kia S, Lacomis D, Malik A, Qi Z, Koontz D, Burlingame RW, Oddis CV Tags: Scand J Rheumatol Source Type: research

PET Scan: Nuclear Medicine Imaging in Myositis
AbstractPurpose of ReviewPositron emission tomography (PET) combined with computed tomography (CT) has proven useful as a cancer screening technique in patients with inflammatory myopathy, mainly dermatomyositis. In this review, we focus on advances in this direction and other potential applications of PET/CT in patients with inflammatory myopathy.Recent FindingsCancer screening by PET/CT seems suitable and cost-effective in patients with myositis. It has also shown value as a hybrid technique for diagnosing myositis versus controls and could be of interest for differentiating between polymyositis and sporadic inclusion bo...
Source: Current Rheumatology Reports - November 20, 2019 Category: Rheumatology Source Type: research

Regional brain atrophy in gray and white matter is associated with cognitive impairment in Myotonic Dystrophy type 1
ConclusionsIn this study, we describe the structural brain signatures that delineate the involvement of the CNS in DM1. We show that specific sensory and multi-sensory — as well as frontal cortical areas — display potential vulnerability associated with the hypothesized neurodegenerative nature of DM1 brain abnormalities.
Source: NeuroImage: Clinical - November 7, 2019 Category: Radiology Source Type: research

Anti-signal Recognition Particle Antibody-positive Necrotizing Myopathy with Secondary Cardiomyopathy: The First Myocardial Biopsy- and Multimodal Imaging-proven Case.
Authors: Takeguchi-Kikuchi S, Hayasaka T, Katayama T, Kano K, Takahashi K, Saito T, Sawada J, Minoshima A, Sakamoto N, Akasaka K, Miyokawa N, Nishino I, Ishibashi-Ueda H, Hasebe N Abstract A 69-year-old Japanese woman was admitted to our hospital with progressive muscle weakness and dysphagia. She was taking pitavastatin for dyslipidemia. Her serum creatine kinase was 6,300 U/L. Pitavastatin was stopped, but her symptoms deteriorated, and cardiac congestion appeared. A muscle biopsy showed necrotizing myopathy (NM), and anti-signal recognition particle (SRP) antibody was positive. 18F-fluorodeoxyglucose-positron em...
Source: Internal Medicine - July 13, 2019 Category: Internal Medicine Tags: Intern Med Source Type: research