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Infectious Disease: Hepatitis B

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Total 38 results found since Jan 2013.

Unexpected SARS-CoV-2 cardiorespiratory arrest in a myopathy patient undergoing immunosuppressive treatment: A case report
We present an unique circumstance whereas a patient with a 5 year history of inflammatory muscle disease, diagnosed by clinical history and muscle biopsy with elevated creatine kinase levels, suffered a hypoxemic cardiopulmonary arrest due to asymptomatic SARS-CoV-2 after receiving advanced immunosuppressive therapy. Diagnoses: The patient presented with an acute exacerbation of inflammatory muscle disease with dysphagia, muscle weakness, and elevated creatine kinase. Interventions: After no improvement with intravenous immunoglobulin the patient received mycophenolate and plasma exchange therapy. Outcomes: Subseq...
Source: Medicine - July 24, 2020 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

ATI-2173, A Novel Liver-Targeted Non-Chain Terminating Nucleotide for HBV Cure Regimens.
Abstract ATI-2173 is a novel liver-targeted molecule designed to deliver the 5'-monophosphate of clevudine for the treatment of chronic hepatitis B. Unlike other nucleos(t)ides, the active clevudine-5'-triphosphate is a noncompetitive, non-chain terminating inhibitor of HBV polymerase that delivers prolonged reduction of viremia in both a woodchuck HBV model and in humans up to six months after cessation of treatment. However, long-term clevudine treatment was found to exhibit reversible skeletal myopathy in a small subset of patients and was subsequently discontinued from development. ATI-2173 was designed by mod...
Source: Antimicrobial Agents and Chemotherapy - June 14, 2020 Category: Microbiology Authors: Squires KE, Mayers DL, Bluemling GR, Kolykhalov AA, Guthrie DB, Reddy P, Mitchell DG, Saindane MT, Sticher ZM, Edpuganti V, De La Rosa A Tags: Antimicrob Agents Chemother Source Type: research

EP.17Vaccination as possible trigger of anti-SRP mediated necrotizing myopathy - a case report
Immunomediated necrotizing myopathy (IMNM) belongs to a heterogeneous group of inflammatory myopathies caused by myositis-specific autoantibodies including anti –3-hydroxy-3- methylglutaryl-coenzyme A (anti-HMGCR) and anti–single recognition particle (anti-SRP). IMNM anti-SRP typically presents with proximal weakness, myalgia, elevated CK and necrosis with absence of inflammation on muscle biopsy. Objective: to describe a case of IMNM anti-SRP positive after vaccination. A 42-year-old female complained of myalgia and muscle weakness affecting the neck and shoulder girdle 2 weeks after vaccination for Yellow fever, Teta...
Source: Neuromuscular Disorders - September 30, 2019 Category: Neurology Authors: J. Cavalcanti, W. Lima, K. Turke, L. Silva, A. Carvalho Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Dermatomyositis as an extrahepatic manifestation of hepatitis B virus-related hepatocellular carcinoma: A case report and literature review
We reported a case of dermatomyositis with hepatitis B virus (HBV) infection. He incidentally found his lower limbs little weakness accompanied with his wrist erythema. He was found HBsAg positive for forty years with slightly positive of α-fetal protein (AFP). Diagnoses: A dermapathology from his hand-wrist lesions demonstrated a scattered inflammatory infiltrate around the capillaries of the dermis. Abdominal enhanced computer tomography (CT) revealed infiltrative HCC affecting the whole liver, accompanied by liver metastasis and liver cirrhosis. Liver tumor needle biopsy pathology showed HCC with moderate differenti...
Source: Medicine - August 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

The Ca(2+) / CaMKK2 Axis Mediates the Telbivudine Induces Upregulation of Creatine Kinase: Implications for mechanism of Antiviral Nucleoside Analogs Side Effect.
Abstract Telbivudine (LdT), a widely prescribed anti-hepatitis B virus (HBV) drug for the treatment of chronic Hepatitis B (CHB), causes adverse reactions ranging from creatine kinase (CK) elevation to myopathy. The purpose of this study was to explore the mechanism(s) of LdT induced CK elevation. The effects of LdT on mitochondrial morphology and proteins (TK2 and β-actin), oxidative stress, intracellular Ca(2+) levels, Ca(2+)-related signaling pathway (CaMKK2/AMPK), and Ca(2+)-related biomarkers such as superoxide dismutase (SOD) and malondialdehyde (MDA) were assessed in human skeletal muscle cells (HSKMCs). T...
Source: Biochemical Pharmacology - October 13, 2017 Category: Drugs & Pharmacology Authors: Jianfei L, Min W, Chunlai M, Bicui C, Jiming Z, Bin W Tags: Biochem Pharmacol Source Type: research

Clevudine Induced Mitochondrial Myopathy.
Authors: Park SH, Park KS, Kim NH, Cho JY, Koh MS, Lee JH Abstract Clevudine was approved as an antiviral agent for hepatitis B virus, which showed marked, rapid inhibition of virus replication without significant toxicity. However, several studies have reported myopathy associated with clevudine therapy. Also, we experienced seven patients who suffered from myopathy during clevudine therapy. To characterize clevudine-induced myopathy, we collected previously reported cases of clevudine myopathy and analyzed all the cases including our cases. We searched electronic databases that were published in English or Korean...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Dermatomyositis Induced by Hepatitis B Virus-related Hepatocellular Carcinoma: A Case Report and Review of the Literature.
Authors: Chou JW, Lin YL, Cheng KS, Wu PY, Reanne Ju T Abstract Dermatomyositis or polymyositis as a paraneoplastic syndrome of hepatocellular carcinoma (HCC) is an uncommon event. Few cases have been reported in the literature. We herein report the case of a 55-year-old man with chronic hepatitis B and alcoholism who presented with skin rash. Abdominal computed tomography revealed multiple hypervascular liver tumors consistent with HCC. He subsequently developed dysphagia with proximal limb weakness. Laboratory tests and electromyography demonstrated inflammatory myopathy. We therefore diagnosed the patient with H...
Source: Internal Medicine - July 20, 2017 Category: Internal Medicine Tags: Intern Med Source Type: research

Necrotizing myopathy in two patients after the use of Moringa (P2.137)
Conclusions:Analogous to statins, Moringa may be associated with necrotizing myopathy.Disclosure: Dr. Treidler has nothing to disclose. Dr. Arya has nothing to disclose. Dr. Seidman has nothing to disclose. Dr. Somasundaram has nothing to disclose. Dr. Anziska has received research support from Pfizer. Dr. Marchidann has nothing to disclose. Dr. Maccabee has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Treidler, S., Arya, K., Seidman, R., Somasundaram, M., Anziska, Y., Marchidann, A., Maccabee, P. Tags: Myopathies & amp;amp; Myasthenia Gravis II Source Type: research

Adverse effects of oral antiviral therapy in chronic hepatitis B.
Authors: Kayaaslan B, Guner R Abstract Oral nucleoside/nucleotide analogues (NAs) are currently the backbone of chronic hepatitis B (CHB) infection treatment. They are generally well-tolerated by patients and safe to use. To date, a significant number of patients have been treated with NAs. Safety data has accumulated over the years. The aim of this article is to review and update the adverse effects of oral NAs. NAs can cause class adverse effects (i.e., myopathy, neuropathy, lactic acidosis) and dissimilar adverse effects. All NAs carry a "Black Box" warning because of the potential risk for mitochondrial dysfunc...
Source: World Journal of Hepatology - March 8, 2017 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Childhood Macrophagic Myofasciitis: A series from the Indian subcontinent
Conclusion: MMF is a rare inflammatory myopathy that should be considered in the differential diagnosis of congenital myopathies in children. This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - November 10, 2016 Category: Internal Medicine Authors: Aanchal Kakkar, Madhu Rajeshwari, Aasma Nalwa, Vaishali Suri, Chitra Sarkar, Biswaroop Chakrabarty, Sheffali Gulati, Mehar C Sharma Tags: Research Article Source Type: research

Delayed-onset Clevudine-induced myopathy: A case report
Clevudine is one of oral anti-viral agents for chronic hepatitis B patients, which is introduced as a nucleoside analogue inhibiting viral reverse transcriptase. Previous case reports described that 4 –15% of patients with long-term treatment of clevudine developed drug-induced myopathy within 6–24 months from the administration. Pathologic evidence supporting mitochondrial cytotoxicity, clevudine-induced myopathy is recovered by discontinuation of causative agents within 4 months in most cas es. In contrast to the precedent cases, we reported a patient of exceptionally delayed myotoxicity after 6 years of clevudine therapy.
Source: Neuromuscular Disorders - September 10, 2016 Category: Neurology Authors: D. Yoo, J. Shin Source Type: research

Telbivudine in liver transplant recipients: Renal protection does not overcome the risk of polyneuropathy and myopathy
In conclusion, although it seems to have a favorable effect in the improvement of renal function and to be effective in the prevention of HBV recurrence, the high risk of polyneuropathy and myopathy hamper the use of telbivudine in LT recipients. This article is protected by copyright. All rights reserved.
Source: Liver Transplantation - April 2, 2015 Category: Transplant Surgery Authors: Ilker Turan, Suna Yapali, Fikret Bademkiran, Timur Kose, Soner Duman, Murat Sozbilen, Fulya Gunsar, Galip Ersoz, Ulus Salih Akarca, Omer Ozutemiz, Zeki Karasu Tags: Original Articles Source Type: research

Lamivudine/telbivudine-associated neuromyopathy: neurogenic damage, mitochondrial dysfunction and mitochondrial DNA depletion
Conclusions MtDNA depletion results in mitochondrial dysfunction in the lamivudine/telbivudine-associated neuromyopathy. Myopathy was characterised by mitochondrial dysfunction accompanied with neurogenic damage due to axonal neuropathy. Ultrastructure changes of mitochondria included vacuolisation, simplification of the cristae and homogenised matrix.
Source: Journal of Clinical Pathology - October 16, 2014 Category: Pathology Authors: Xu, H., Wang, Z., Zheng, L., Zhang, W., Lv, H., Jin, S., Yuan, Y. Tags: Liver disease, Open access, Hepatitis and other GI infections, Muscle disease, Musculoskeletal syndromes, Hepatitis (sexual health), Clinical diagnostic tests Original article Source Type: research

Continuous Venovenous Hemodiafiltration for Hyperlactatemia Caused by Telbivudine in a Patient with Chronic Hepatitis B: A Case Report and Update Review
Abstract Though telbivudine has been reported causing myopathy and elevating creatine kinase (CK), there is still few reports on telbivudine and hyperlactatemia in patients with chronic hepatitis B. Here we report the case of hyperlactaemia during telbivudine treatment. A 26‐year‐old Chinese origin man has been received telbivudine antiviral treatment for chronic hepatitis B since 3 July, 2011, and found the CK was 68 U/L before the anti‐viral treatment. After 3 months of therapy, he generally felt nausea and vomited frequently. The CK checked in local clinic was up to 222 U/L (upper limit of normal 170 U/L). However...
Source: Chinese Journal of Digestive Diseases - June 1, 2014 Category: Gastroenterology Authors: Yan‐Hong Wang, Ben‐Quan Wu, Hui Liu Tags: Case Report Source Type: research