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Infectious Disease: Hepatitis B

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Total 38 results found since Jan 2013.

Insights into the mechanisms of telbivudine-induced myopathy associated with mitochondrial dysfunction
In conclusion, our study provides compelling evidence suggesting that telbivudine-induced myopathy is associated with mitochondrial toxicity and impaired energy metabolism. The observed muscle pathology, depletion of mtDNA, elevation of oxidative stress and altered mitochondrial function support the hypothesis that telbivudine disrupts mitochondrial homeostasis, ultimately leading to muscle damage. This may be also a common mechanism for NAs to cause neuromyopathy.PMID:37659625 | DOI:10.1016/j.cbi.2023.110692
Source: Chemico-Biological Interactions - September 2, 2023 Category: Molecular Biology Authors: Wenfei Yu Zhuxvn Li Wenjing Wu Dandan Zhao Chuanzhu Yan Pengfei Lin Source Type: research

Telbivudine-Induced Myopathy: Clinical Features, Histopathological Characteristics, and Risk Factors
CONCLUSIONS: Mitochondrial abnormalities are characteristic histopathological features, and impaired renal function and HBeAg positivity are risk factors for TIM. Telbivudine-induced mitochondrial dysfunction and immune activation related to mitochondrial damage and HBeAg serostatus changes may underlie TIM. Constant clinical surveillance of myopathy during telbivudine treatment is needed due to the significant latency of its development. Dose adjustment for impaired renal function does not eliminate the risk of TIM occurrence.PMID:36606646 | DOI:10.3988/jcn.2023.19.1.52
Source: Journal of Clinical Neurology - January 6, 2023 Category: Neurology Authors: Min-Yu Lan Hui-Chen Lin Tsung-Hui Hu Shu-Fang Chen Chien-Hung Chen Yung-Yee Chang King-Wah Chiu Tsu-Kung Lin Shun-Sheng Chen Source Type: research

Respiratory failure as the prominent manifestation of entecavir-associated mitochondrial myopathy: a case report
Mitochondrial myopathy caused by the long-term use of nucleos(t)ide analogue in patients with chronic hepatitis B (CHB) is mostly characterized by myasthenia and myalgia. Cases with respiratory failure as the ...
Source: BMC Infectious Diseases - February 24, 2022 Category: Infectious Diseases Authors: Xiao Lin, Aixin Song, Sujun Zheng and Xinyue Chen Tags: Case report Source Type: research

Efficacy and Safety of Statin for Hepatocellular Carcinoma Prevention Among Chronic Liver Disease Patients: A Systematic Review and Meta-analysis
Conclusion: Statin use was safe and associated with a lower pooled risk of HCC development among adults with CLD. Given the bias with observation studies, prospective randomised trial is needed to confirm this finding.
Source: Journal of Clinical Gastroenterology - July 15, 2021 Category: Gastroenterology Tags: Liver, Pancreas & Biliary Tract: Original Articles Source Type: research

P039  Muscle wasting & amp; weakness: a rare presentation of sarcoidosis
Conclusion Symptomatic myopathy is present in only 0.5-2.5% of sarcoidosis patients. This unique case highlights the heterogeneity of this disease and the vital role different diagnostic modalities play in achieving the correct diagnosis. It is also pertinent that the lymphadenopathy, found incidentally via imaging, led to the diagnosis. Although notoriously a diagnosis of exclusion, this case emphasises the importance of considering sarcoidosis even in the absence of respiratory symptoms, a raised ACE or hypercalcaemia.Disclosure C. Tomlinson: None.A. Khan: None.D. Mukerjee: None.N. Bhadauria: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Necrotizing Myopathy Resulting In Myocarditis And Sudden Death
Necrotizing myopathy (NM), a type of idiopathic inflammatory myopathy (IIM), is an autoimmune disorder in which immune cells target skeletal muscle, resulting in muscle breakdown and weakness. Cardiac involvement in this disorder is rare. We highlight a case of autoantibody-negative NM complicated by myocarditis and sudden cardiac death.Case Report: A 45-year-old male with a history of hypertension, previous hepatitis B, and obesity presented with 6 months of progressive proximal lower extremity weakness.
Source: Journal of Cardiac Failure - September 30, 2020 Category: Cardiology Authors: Reynaldo Homero Sanchez, Jeremy Slivnick, Ashly Cordero Rivera, Ajay Vallakati Tags: 120 Source Type: research