Filtered By:
Education: Grants

This page shows you your search results in order of date.

Order by Relevance | Date

Total 22 results found since Jan 2013.

Skeletal Muscle Bioenergetics in Critical Limb Ischemia and Diabetes
Mitochondrial dysfunction is implicated in the metabolic myopathy accompanying peripheral artery disease (PAD) and critical limb ischemia (CLI). Type-2 diabetes mellitus (T2DM) is a major risk factor for PAD development and progression to CLI and may also independently be related to mitochondrial dysfunction. We set out to determine the effect of T2DM in the relationship between CLI and muscle mitochondrial respiratory capacity and coupling control.
Source: Journal of Surgical Research - March 22, 2023 Category: Surgery Authors: Victoria G. Rontoyanni, Elizabeth Blears, Omar Nunez Lopez, John Ogunbileje, Tatiana Moro, Nisha Bhattarai, Amanda C. Randolph, Christopher S. Fry, Grant T. Fankhauser, Zulfiqar F. Cheema, Andrew J. Murton, Elena Volpi, Blake B. Rasmussen, Porter Craig Tags: Vascular Surgery Source Type: research

The Impact of Resistance Exercise on Muscle Mass in Glioblastoma in Survivors (RESIST): Protocol for a Randomized Controlled Trial
CONCLUSIONS: This study will inform how individualized circuit-based resistance training may improve functional independence and overall QOL of glioblastoma patients.TRIAL REGISTRATION: ClinicalTrails.gov NCT05116137; https://www.clinicaltrials.gov/ct2/show/NCT05116137.INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/37709.PMID:35507403 | DOI:10.2196/37709
Source: Cancer Control - May 4, 2022 Category: Cancer & Oncology Authors: Melanie R Keats Scott A Grandy Christopher Blanchard Jonathon R Fowles Heather F Neyedli Adrienne C Weeks Mary V MacNeil Source Type: research

An autopsy case of anti-hydroxy-3-methylglutaryl-coenzyme A reductase myopathy with involvement of the heart, lungs and respiratory muscles
Intramural Research Grant (2 –5) for Neurological and Psychiatric Disorders of the National Center of Neurology and Psychiatry
Source: Rheumatology - March 25, 2021 Category: Rheumatology Source Type: research

Inborn errors of mitochondrial acyl-coenzyme a metabolism: acyl-CoA biology meets the clinic
Publication date: Available online 9 May 2019Source: Molecular Genetics and MetabolismAuthor(s): Hao Yang, Chen Zhao, Marie-Christine Tang, Youlin Wang, Shu Pei Wang, Pierre Allard, Alexandra Furtos, Grant A. MitchellAbstractThe last decade saw major advances in understanding the metabolism of Coenzyme A (CoA) thioesters (acyl-CoAs) and related inborn errors (CoA metabolic diseases, CAMDs). For diagnosis, acylcarnitines and organic acids, both derived from acyl-CoAs, are excellent markers of most CAMDs. Clinically, each CAMD is unique but strikingly, three main patterns emerge: first, systemic decompensations with combinat...
Source: Molecular Genetics and Metabolism - May 10, 2019 Category: Genetics & Stem Cells Source Type: research

Blood Levels of Co-inhibitory-Receptors: A Biomarker of Disease Prognosis in Multiple Sclerosis
Discussion Our main finding is that LAG-3 and TIM-3 expression levels in the PBMCs of MS patients can aid to predict disease outcome. Lower LAG-3 and TIM-3 expression were associated with the worst outcome and increased likelihood to progress to SPMS, while higher LAG-3 and TIM-3 expression correlated significantly with benign prognosis, persisting RRMS, and lower EDSS score at 10 years after blood sampling. Analysis of the paraclinical and clinical parameters baseline brain MRI T2LV, EDSS at diagnosis, and 1-year progression index combined with LAG-3 and TIM-3 expression levels resulted in superior ability to identify pa...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Comparison of Three Immunoassays for the Detection of Myositis Specific Antibodies
Conclusion: The data hold promise for advancements in standardization of MSA assays as well as for the potential inclusion of MSA in future classification criteria. Introduction Myositis specific (MSA) and myositis associated antibodies (MAA) have been used as an aid in the diagnosis of idiopathic inflammatory myopathies (IIM) for decades (1). Since many of the MSA (e.g., anti-synthetase antibodies), partly depending on the screening dilution, are accompanied by limited sensitivity of the indirect immunofluorescence (IIF) test, this method has limited utility as a screening test for suspected myositis (2–6)...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Scurfy Mice Develop Features of Connective Tissue Disease Overlap Syndrome and Mixed Connective Tissue Disease in the Absence of Regulatory T Cells
Discussion Treg represent a lineage of T cells which play a fundamental role in maintaining humoral tolerance in the periphery. This subset of “suppressor T cells” is identified as FoxP3-expressing CD4+ T cells (16, 17). The unrestrained expression of FoxP3 is essential for the development and function of Treg (4). Accordingly, a disruption of the Foxp3 gene in scurfy mice results in an autoimmune lymphoproliferative disorder with fatal multi-organ inflammation (18). Since the causative mutation occurs in orthologous genes, the scurfy phenotype is indicated as the murine equivalent of the human IPEX sy...
Source: Frontiers in Immunology - April 23, 2019 Category: Allergy & Immunology Source Type: research

A Chinese Family With Adult-Onset Leigh-Like Syndrome Caused by the Heteroplasmic m.10191T > C Mutation in the Mitochondrial MTND3 Gene
Conclusion The m.10191T>C mutation in the mtDNA of the complex I (CI) subunit of MTND3 results in the substitution of a highly conserved amino acid (p.Ser45Pro) within the ND3 protein, leading to CI dysfunction through impaired enzyme catalysis rather than impaired stability or assembly, causing a broad clinical spectrum of disorders (26). Patients with the m.10191T>C mutation are rare. In the present study, we report on a family of patients with the extremely rare adult-onset Leigh-like syndrome with the m.10191T>C mutation. Including the two patients from our reported family, the m.10191T...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research

Corticospinal Tract Integrity and Long-Term Hand Function Prognosis in Patients With Stroke
Conclusions: The present study showed that CST integrity (at 6 months after onset) in patients with chronic stroke was related to functional hand status. In addition, the mid-pons FA value was more predictive of functional restoration of the hand than the FN or FA value at the pontomedullary junction. These results may be useful in predicting the functional restoration of the hand and understanding the functional prognosis of stroke. Introduction Restoration of hand function is one of the most important goals for patients with stroke (1). Thus, techniques that aid in predicting restoration of hand function are also i...
Source: Frontiers in Neurology - April 14, 2019 Category: Neurology Source Type: research

Influenza A Virus Infection Damages Zebrafish Skeletal Muscle and Exacerbates Disease in Zebrafish Modeling Duchenne Muscular Dystrophy
DISCUSSION Here, we investigated the effects of an infectious disease on skeletal muscle tissue alone and in combination with a genetic muscle disease. We found that human IAV can infect zebrafish muscle fibers and cause fiber damage via loss of sarcolemma integrity and/or loss of ECM adhesion external to the sarcolemma. Additionally, we showed that molecular and cellular markers of inflammation are present in muscle tissue in response to IAV infection. Finally, we showed that an infectious disease in combination with a genetic muscle disease greatly worsens the severity of muscle tissue degeneration. Taken together, our r...
Source: PLOS Currents Muscular Dystrophy - October 25, 2017 Category: Neurology Authors: Clarissa Henry Source Type: research

Genome-wide Association Study of Susceptibility to Particulate Matter –Associated QT Prolongation
Conclusions: The findings suggest that biologically plausible genetic factors may alter susceptibility to PM10-associated QT prolongation in populations protected by the U.S. Environmental Protection Agency’s National Ambient Air Quality Standards. Independent replication and functional characterization are necessary to validate our findings. https://doi.org/10.1289/EHP347 Received: 11 April 2016 Revised: 07 September 2016 Accepted: 19 September 2016 Published: 08 June 2017 Address correspondence to R. Gondalia, Department of Epidemiology, University of North Carolina, 137 E. Franklin St., Chapel Hill, NC 27514. Te...
Source: EHP Research - June 8, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Mitochondrial Bioenergetics in the Metabolic Myopathy Accompanying Peripheral Artery Disease
Victoria G. Rontoyanni, Omar Nunez Lopez, Grant T. Fankhauser, Zulfiqar F. Cheema, Blake B. Rasmussen, Craig Porter
Source: Frontiers in Physiology - March 13, 2017 Category: Physiology Source Type: research

Establishment of a new human muscle microvascular endothelial cell line (P3.368)
CONCLUSION: We successfully established a conditionally immortalized human muscle microvascular endothelial cell line. This cell line might facilitate analyses for pathophysiology of inflammatory myopathy such as DM and would be useful in the study of drug delivery targeting the skeletal muscle. Study Supported by: Research grant (26461271) from the Japan Society for the Promotion of Science, Tokyo, Japan.Disclosure: Dr. Sano has nothing to disclose. Dr. Sano has nothing to disclose. Dr. Omoto has nothing to disclose. Dr. Kanda has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Sano, Y., Sano, H., Omoto, M., Kanda, T. Tags: General Neurology Source Type: research

Complex sarcolemmal invaginations mimicking myotendinous junctions in a case of Laing early‐onset distal myopathy
Distal myopathies are a group of clinically and pathologically overlapping muscle diseases that are genetically complex and can represent a diagnostic challenge. Laing early‐onset distal myopathy (MPD1) is a form of distal myopathy caused by mutations in the MYH7 gene, which encodes the beta myosin heavy chain protein expressed in type 1 skeletal muscle fibers and cardiac myocytes. Here, we present a case of genetically confirmed MPD1 with a typical clinical presentation but distinctive light microscopic and ultrastructural findings on muscle biopsy. A 39‐year‐old professional male cellist presented with a bilateral ...
Source: Neuropathology - June 10, 2015 Category: Neurology Authors: Gerald F. Reis, Grant Motte, Rebecca Gooding, Nigel G. Laing, Marta Margeta Tags: Case Report Source Type: research

A new muscle glycogen storage disease associated with Glycogenin-1 deficiency (S34.002)
CONCLUSIONS: In summary, we have described a new muscle glycogen storage disorder that is due to deficiency of glycogenin-1, and that binding of glycogen synthase to the C-terminal of glycogenin-1 is essential for glycogen synthase activity. Study Supported by: Supported by a grant 7122, from the Swedish Research Council.Disclosure: Dr. Malfatti has nothing to disclose. Dr. Nilsson has nothing to disclose. Dr. Hedberg-Oldfors has nothing to disclose. Dr. Hernandez-Lain has nothing to disclose. Dr. Viennet has nothing to disclose. Dr. Dominguez-Gonzalez has nothing to disclose. Dr. Michel has nothing to disclose. Dr. Ackman...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Malfatti, E., Nilsson, J., Hedberg-Oldfors, C., Hernandez-Lain, A., Viennet, G., Dominguez-Gonzalez, C., Michel, F., Ackman, H., Kornblum, C., Van den Bergh, P., Romero, N., Engel, A., DiMauro, S., Oldfors, A. Tags: Neuromuscular Update Platform Blitz Source Type: research