Skeletal Muscle Bioenergetics in Critical Limb Ischemia and Diabetes

Mitochondrial dysfunction is implicated in the metabolic myopathy accompanying peripheral artery disease (PAD) and critical limb ischemia (CLI). Type-2 diabetes mellitus (T2DM) is a major risk factor for PAD development and progression to CLI and may also independently be related to mitochondrial dysfunction. We set out to determine the effect of T2DM in the relationship between CLI and muscle mitochondrial respiratory capacity and coupling control.

Source: Journal of Surgical Research - March 22, 2023 Category: Surgery Authors: Victoria G. Rontoyanni, Elizabeth Blears, Omar Nunez Lopez, John Ogunbileje, Tatiana Moro, Nisha Bhattarai, Amanda C. Randolph, Christopher S. Fry, Grant T. Fankhauser, Zulfiqar F. Cheema, Andrew J. Murton, Elena Volpi, Blake B. Rasmussen, Porter Craig Tags: Vascular Surgery Source Type: research