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Frequently Asked Questions on Coronavirus Disease 2019 Vaccination for Hematopoietic Cell Transplant and Chimeric Antigen Receptor T-Cell Recipients From the American Society for Transplantation and Cellular Therapy and the American Society of Hematology
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may now be endemic in the United States and worldwide.1 Hematopoietic cell transplant (HCT) and chimeric antigen receptor T (CAR T)-cell recipients remain at higher risk for severe complications from the virus, including hospitalization, (intensive care unit) admission, and death from coronavirus disease 2019 (COVID-19).2-5 HCT and CAR T-cell recipients also have other comorbidities associated with COVID-19 –related mortality, including older age, cardiovascular disease, chronic lung disease, diabetes, renal dysfunction, and high-level immunosuppression.
Source: Biology of Blood and Marrow Transplantation - October 20, 2022 Category: Hematology Authors: Fareed Khawaja, Genovefa Papanicolaou, Sanjeet Dadwal, Steven A. Pergam, John R. Wingard, Zeinab El Boghdadly, Maheen Z. Abidi, Alpana Waghmare, Zainab Shahid, Laura Michaels, Joshua A. Hill, Mini Kamboj, Michael Boeckh, Jeffery J. Auletta, Roy F. Chemaly Source Type: research

Clinical course and outcomes of COVID-19 in kidney transplant recipients
Conclusion: COVID-19 in kidney transplant recipients is associated with a high risk of AKI and significant mortality.
Source: Indian Journal of Nephrology - October 12, 2022 Category: Urology & Nephrology Authors: Divya Bajpai Satarupa Deb Sreyashi Bose Chintan P Gandhi Tulsi Modi Abhinav Katyal Nikhil Saxena Ankita Patil Sunil Patil Sayali Thakare Atim Pajai Ashwathy Haridas Vaibhav S Keskar Sunil Y Jawale Amar G Sultan Gita Nataraj Nayana Ingole Tukaram E Jamale Source Type: research

Correspondence on 'Lung involvement in macrophage activation syndrome and severe COVID-19: results from a cross-sectional study to assess clinical, laboratory and artificial intelligence-radiological differences by Ruscitti et al
Our research team read Ruscitti et al’s article regarding lung involvement in coronavirus disease 2019 (COVID-19) and macrophage activation syndrome (MAS) with great interest.1 This topic not only addresses the current pandemic, but also is of concern in our team’s expertise—rheumatology. As we thoroughly examined the details of this research study, we noticed a few points we would like to address and discuss: the definition of patient selection criteria, the necessity of differentiating among COVID-19 CT patterns, the pathogenic mechanism differences between MAS and COVID-19, and the potential relationsh...
Source: Annals of the Rheumatic Diseases - October 12, 2022 Category: Rheumatology Authors: Chen, A. I.-H., Lin, S.-C., Wei, J. C.-C. Tags: ARD, COVID-19 Correspondence Source Type: research

Response to: 'Correspondence on 'Lung involvement in macrophage activation syndrome and severe COVID-19: results from a cross-sectional study to assess clinical, laboratory and artificial intelligence-radiological differences by Ruscitti et al by Chen et al
Dear Editor, We read with interest the correspondence by Chen et al1 about our recent article on the comparison of clinical, laboratory and artificial intelligence–radiological findings in patients with lung involvement either from macrophage activation syndrome (MAS), a secondary form of haemophagocytic lymphohistiocytosis (HLH) or severe coronavirus disease 2019 (COVID-19).2 Age is one of the most common confounding factors in any observational study since it is associated with an increased risk of comorbidities, which may influence the outcome. In our study, the matching for age was not reliable because of higher ...
Source: Annals of the Rheumatic Diseases - October 12, 2022 Category: Rheumatology Authors: Ruscitti, P., Bruno, F., Berardicurti, O., Acanfora, C., Pavlych, V., Palumbo, P., Conforti, A., Carubbi, F., Di Cola, I., Di Benedetto, P., Cipriani, P., Grassi, D., Masciocchi, C., Iagnocco, A., Barile, A., Giacomelli, R. Tags: ARD, COVID-19 Correspondence response Source Type: research

Heart transplantation for COVID-19 myopathy in the United States
Evidence on characteristics and outcomes of patients undergoing heart transplantation for coronavirus disease 2019 (COVID-19) associated cardiomyopathy is limited to case reports. Of all 6332 patients aged ≥18 years undergoing heart transplant from July 2020 through May 2022 in the United Network for Organ Sharing database, 12 (0.2%) patients had COVID-19 myocarditis and 98 (1.6%) patients with the same level of care had non-COVID-19 myocarditis. Their median age was 49 (range 19-74) years. All pati ents were hospitalized in the intensive care unit and 92.7% (n=102) were on life support prior to transplantation.
Source: The Journal of Heart and Lung Transplantation - October 5, 2022 Category: Transplant Surgery Authors: George Gill, Amy Roach, Georgina Rowe, Dominic Emerson, Jon Kobashigawa, Errol P. Lobo, Fardad Esmailian, Michael E. Bowdish, Joanna Chikwe Tags: Brief Communication Source Type: research

Viruses, Vol. 14, Pages 2017: Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection Kinetics
sek Tuna Toptan Some of the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are less susceptible to neutralization with post-vaccine sera and monoclonal antibodies targeting the viral spike glycoprotein. This raises concerns of disease control, transmissibility, and severity. Numerous substitutions have been identified to increase viral fitness within the nucleocapsid and nonstructural proteins, in addition to spike mutations. Therefore, we sought to generate infectious viruses carrying only the variant-specific spike mutations in an identical backbone to evaluate the impact of spike an...
Source: Viruses - September 12, 2022 Category: Virology Authors: Andrei Veleanu Maximilian A. Kelch Chengjin Ye Melanie Flohr Alexander Wilhelm Marek Widera Luis Martinez-Sobrido Sandra Ciesek Tuna Toptan Tags: Article Source Type: research

Outcome of lung transplant recipients infected with SARS-CoV-2/Omicron/B.1.1.529: a Nationwide German study
ConclusionCOVID-19 due to Omicron remains an important threat for lung transplant recipients. In particular, elderly patients and patients with impaired kidney function are at risk for worse outcome. Prophylaxis and therapy in highly immunocompromised individuals need further improvement.
Source: Infection - September 9, 2022 Category: Infectious Diseases Source Type: research

Clinical relevance of lung transplantation for COVID-19 ARDS: a nationwide study
Conclusions Early referral of ECMO patients to a LTx centre is pivotal in order to select patients eligible for LTx. Transplantation offers excellent midterm outcomes and should be incorporated in the treatment algorithm of post-COVID-19 ARDS.
Source: European Respiratory Journal - September 7, 2022 Category: Respiratory Medicine Authors: Lang, C., Ritschl, V., Augustin, F., Lang, G., Moser, B., Taghavi, S., Murakoezy, G., Lambers, C., Flick, H., Koestenberger, M., Brooks, R., Muhr, T., Knotzer, J., Mydza, D., Kaufmann, M., Staudinger, T., Zauner, C., Krenn, C., Schaden, E., Bacher, A., Ro Tags: Respiratory infections and tuberculosis Original Articles: Respiratory infection and COVID-19 Source Type: research

Incidence of Coronavirus Infection in Patients Undergoing Kidney Transplant During the Pandemic Period in Uzbekistan
CONCLUSIONS: The Ministry of Health of the Republic of Uzbekistan indicated the possibility of treatment of patients with moderate and severe COVID-19 disease with monoclonal antibodies that block interleukin 6 receptors (tocilizumab and sarilumab). With timely detection of symptoms of COVID-19infection, treatment, and the use of prevention methods, kidney transplant recipients of living related donors had fewer complications of the disease than expected.PMID:36018027 | DOI:10.6002/ect.DonorSymp.2022.O15
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - August 26, 2022 Category: Transplant Surgery Authors: Fazlitdin Sh Bakhritdinov Ravshan A Ibadov Marguba T Azimova Zokhidjon T Matkarimov Dildora N Komilova Nigina B Elmurodova Source Type: research

Sensors, Vol. 22, Pages 6312: Database and AI Diagnostic Tools Improve Understanding of Lung Damage, Correlation of Pulmonary Disease and Brain Damage in COVID-19
The objective of this paper is to perform a systematic review to summarize the electroencephalogram (EEG) findings in patients with coronavirus disease (COVID-19) and databases and tools used in artificial intelligence algorithms, supporting the diagnosis and correlation between lung disease and brain damage, and lung damage. Available search tools containing scientific publications, such as PubMed and Google Scholar, were comprehensively evaluated and searched with open databases and tools used in AI algorithms. This work aimed to collect papers from the period of January 2019–May 2022 including in their res...
Source: Sensors - August 22, 2022 Category: Biotechnology Authors: Ilona Karpiel Ana Starcevic Mirella Urzeniczok Tags: Review Source Type: research

Acute Kidney Injury and Mortality among Patients with Coronavirus Disease-2019 in Pakistan
Saudi J Kidney Dis Transpl. 2021 Nov-Dec;32(6):1764-1774. doi: 10.4103/1319-2442.352439.ABSTRACTThe kidney is the most vulnerable organ in coronavirus disease-2019 (COVID-19) patients besides the lungs, with evidence of acute kidney injury (AKI). We aimed to find the prevalence of AKI among COVID-19 patients and further evaluate the association of between COVID-19 and AKI along with an understanding of mortality. A prospective observational study was conducted among COVID-19 patients admitted to a tertiary care hospital, Hayatabad Medical Complex, between March 2020 and June 2020. Chi-square test was applied for comparativ...
Source: Saudi Journal of Kidney Diseases and Transplantation - August 10, 2022 Category: Urology & Nephrology Authors: Raheel Ahmed Khaola Fazle Maula Zahid Ali Mohammad Ismail Inayat Ur Rehman Sedra Fazle Maula Samina Masood Ali Tahir Mehmood Khan Source Type: research