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Procedure: Lung Transplant

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Total 1013 results found since Jan 2013.

The Potential Importance of CXCL1 in the Physiological State and in Noncancer Diseases of the Cardiovascular System, Respiratory System and Skin
Int J Mol Sci. 2022 Dec 22;24(1):205. doi: 10.3390/ijms24010205.ABSTRACTIn this paper, we present a literature review of the role of CXC motif chemokine ligand 1 (CXCL1) in physiology, and in selected major non-cancer diseases of the cardiovascular system, respiratory system and skin. CXCL1, a cytokine belonging to the CXC sub-family of chemokines with CXC motif chemokine receptor 2 (CXCR2) as its main receptor, causes the migration and infiltration of neutrophils to the sites of high expression. This implicates CXCL1 in many adverse conditions associated with inflammation and the accumulation of neutrophils. The aim of th...
Source: Atherosclerosis - January 8, 2023 Category: Cardiology Authors: Jan Korbecki Agnieszka Maruszewska Mateusz Bosiacki Dariusz Chlubek Irena Baranowska-Bosiacka Source Type: research

Respiratory Viruses and Cystic Fibrosis
This article reviews the epidemiology, diagnosis, and treatment of respiratory virus infection in the context of CF as well as the current understanding of interactions between viruses and other microorganisms in the CF lung. The incidence of respiratory virus infection in CF varies by age with young children typically experiencing more frequent episodes than adolescents and adults. At all ages, respiratory viruses are very common in CF and are associated with pulmonary exacerbations. Respiratory viruses are identified at up to 69% of exacerbations, while viruses are also frequently detected during clinical stability. The ...
Source: Seminars in Respiratory and Critical Care Medicine - December 19, 2022 Category: Respiratory Medicine Authors: Brackenborough, Kate Ellis, Huw Flight, William G. Tags: Review Article Source Type: research

Sensors, Vol. 22, Pages 9983: Detection of COVID-19 in X-Ray Images Using Densely Connected Squeeze Convolutional Neural Network (DCSCNN): Focusing on Interpretability and Explainability of the Black Box Model
In this study, a state-of-the-art CNN model densely connected squeeze convolutional neural network (DCSCNN) has been developed for the classification of X-ray images of COVID-19, pneumonia, normal, and lung opacity patients. Data were collected from different sources. We applied different preprocessing techniques to enhance the quality of images so that our model could learn accurately and give optimal performance. Moreover, the attention regions and decisions of the AI model were visualized using the Grad-CAM and LIME methods. The DCSCNN combines the strength of the Dense and Squeeze networks. In our experiment, seven kin...
Source: Sensors - December 18, 2022 Category: Biotechnology Authors: Sikandar Ali Ali Hussain Subrata Bhattacharjee Ali Athar Abdullah Hee-Cheol Kim Tags: Article Source Type: research

Fight Aging! Newsletter, December 12th 2022
In conclusion, selective removal of senescent dermal fibroblasts can improve the skin aging phenotype, indicating that BPTES may be an effective novel therapeutic agent for skin aging. Non-Dividing Neurons Do In Fact Become Senescent, Impairing Brain Function https://www.fightaging.org/archives/2022/12/non-dividing-neurons-do-in-fact-become-senescent-impairing-brain-function/ Cellular senescence is generally thought of as a characteristic of replicating cells; it is an end state reached when telomeres, reduced in length with each cell division, become too short. This is followed by programmed cell death ...
Source: Fight Aging! - December 11, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Incidence, Risk Factors, and Outcomes of COVID-19 Infection in a Large Cohort of Solid Organ Transplant Recipients
Background. Solid organ transplant recipients (SOTr) are at increased risk for severe disease from coronavirus disease 2019 (COVID-19) compared with non-SOTr. Methods. We performed a retrospective cohort study between March 1, 2020, and March, 30, 2021, in an integrated healthcare system with 4.3 million members aged ≥18 y including 5126 SOTr. Comparisons in COVID-19 mortality, hospitalization, and incidence were made between SOTr and non-SOTr, and between different SOTr organs. Multivariate analysis was performed to identify risk factors for COVID-19 mortality and hospitalization. Results. There were 6...
Source: Transplantation - December 1, 2022 Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

Insights into the lung microenvironment after severe COVID-19
The SARS-CoV-2 is the betacoronavirus responsible for the coronavirus disease 2019 (COVID-19) pandemic. Severe COVID-19 affects approximately 10-15% of patients and results in prolonged morbidity and mortality. Little is known about the immunophenotypic changes of the lung parenchyma driven by the viral infection in patients who die of severe COVID-19.Ultrasound-guided lung biopsies (LB) were collected (IRB approval#1561/21) within few hours from death in 15 severe COVID-19 patients between November 2020 and January 2021, in two patients who underwent lung transplantation after COVID-19 and in one patient who had surg...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Vaira, V., Storaci, A. M., Pitasi, M., Gentile, F., Blasi, F., Morlacchi, L. C., Pesenti, A., Grasselli, G., Tagliabue, P., Clerici, M. S., Malvestiti, F., Valenti, L., Aliberti, S., Gualtierotti, R., Ferrero, S., Nosotti, M., Bandera, A., Gori, A., Peyva Tags: 03.02 - Airway cell biology and immunopathology Source Type: research

Serological response following second and third SARS-CoV-2 vaccines in lung transplant recipients
Conclusion: Immunosuppression therapy may induce weaker SARS-CoV-2 response in LuTX recipients. Our data confirm that non-mRNA vaccines could be safe and effective, however immunity decreases over time, therefore third dose vaccine is a priority in transplanted patients. Further data are needed to evaluate cellular responses after all type of SARS-CoV-2 vaccinations.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Barczi, E., Varga, V., Nagy, A., Eszes, N., Jaky-Kovats, Z., Müller, V., Bohacs, A. Tags: 08.02 - Transplantation Source Type: research

Covid-19 in lung allograft recipients - better outcomes after vaccination?
Vaccination remains a main weapon against Coronavirus Disease 2019 (Covid-19). Although its efficacy is reduced in the immunocompromised population, we felt empirically that outcomes of Covid-19 in lung transplant recipients (LTRs) were better after widespread vaccination than in earlier phases of the pandemic. We aimed to compare outcomes of unvaccinated and vaccinated LTRs infected with SARS-CoV-2. All LTRs followed in our hospital were reviewed and those with a positive polymerase chain reaction test were included. We analysed disease severity (using World Health Organization criteria) and mortality rates in unvacc...
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Oliveira Pinto, M. A., Rodrigues, J., Santos, A. S., Semedo, L. Tags: 08.02 - Transplantation Source Type: research

Impact of COVID-19 social distancing measures on lung transplant recipients: decline in overall respiratory virus infections is associated with stabilisation of lung function
Conclusions During COVID-19 social distancing the strong reduction in respiratory virus circulation coincided with markedly less FEV1 decline, fewer episodes of TDLF and possibly less CLAD. Effect modification by respiratory virus circulation suggests an important role for respiratory viruses in lung function decline in LTRs.
Source: European Respiratory Journal - November 24, 2022 Category: Respiratory Medicine Authors: de Zwart, A. E. S., Riezebos-Brilman, A., Lunter, G. A., Neerken, E. C. U., van Leer-Buter, C. C., Alffenaar, J.-W. C., van Gemert, A. P., Erasmus, M. E., Gan, C. T., Kerstjens, H. A. M., Vonk, J. M., Verschuuren, E. A. M. Tags: Respiratory infections and tuberculosis Original Articles: Lung transplantation and COVID-19 Source Type: research

Lung Transplantation in Coronavirus-19 Patients
Coronavirus-19 (COVID-19) can result in irrecoverable acute respiratory distress syndrome (ARDS) or life-limiting fibrosis for which lung transplantation is currently the only viable treatment. COVID-19 lung transplantation has transformed the field of lung transplantation, as before the pandemic, few transplants had been performed in the setting of infectious disease or ARDS. Given the complexities associated with COVID-19 lung transplantation, it requires strict patient selection with an experienced multidisciplinary team in a high-resource hospital setting. Current short-term outcomes of COVID-19 lung transplantation ar...
Source: Clinics in Chest Medicine - November 21, 2022 Category: Respiratory Medicine Authors: Emily Cerier, Kalvin Lung, Chitaru Kurihara, Ankit Bharat Source Type: research

Association of major postoperative wound and anastomotic complications in thoracic surgery with COVID-19 infection
CONCLUSIONS: COVID-19 infection should be included in differential diagnosis in postoperative patients with major wound or anastomosis complications.PMID:36373161 | PMC:PMC9637540 | DOI:10.1016/j.sopen.2022.10.008
Source: Cancer Control - November 14, 2022 Category: Cancer & Oncology Authors: Kajetan Kie łbowski Ma łgorzata Wojtyś Konstantinos Kostopanagiotou Henryk Janowski Janusz W ójcik Source Type: research

Lung transplantation in patients with lung disease secondary to coronavirus disease 2019 infection
Purpose of review In this article, we describe preoperative patient selection and outcomes of patients with lung disease secondary to infection from COVID-19 who receive lung transplantation. Recent findings Lung transplants for patients with lung disease secondary to infection from COVID-19 have been performed successfully in over 200 patients in the United States. The preoperative course of these patients is somewhat atypical in comparison with patients who have had lung transplants related to chronic lung diseases, where there are more traditional indications for lung transplants. COVID-19 patients have more ...
Source: Current Opinion in Critical Care - November 3, 2022 Category: Nursing Tags: ICU EXPERIENCES FROM COVID 19: Edited by Luigi Camporota Source Type: research

Lung Transplantation for Coronavirus Disease-2019 Patients and Coronavirus Disease-2019 in Lung Transplant Recipients
Lung transplant is a life-saving treatment for carefully selected patients with respiratory failure related to the infection with coronavirus disease-2019. Despite a complex pretransplant medical course, the posttransplant outcomes are excellent when performed by experienced centers.
Source: Clinics in Chest Medicine - November 3, 2022 Category: Respiratory Medicine Authors: Diego Avella, Henry Neumann, Ankit Bharat Source Type: research

Efficacy and safety of the SARS-CoV-2 mRNA vaccine in lung transplant recipients: a possible trigger of rejection
ConclusionsThe antibody response to the SARS-CoV-2 mRNA vaccine was quite poor in lung transplant recipients. We experienced cases that developed clinical CLAD or AMR that was likely related to SARS-CoV-2 vaccination.
Source: General Thoracic and Cardiovascular Surgery - October 26, 2022 Category: Cardiovascular & Thoracic Surgery Source Type: research

Automated diagnosis of COVID-19 using radiological modalities and Artificial Intelligence functionalities: A retrospective study based on chest HRCT database
CONCLUSION: : Typical multifocal, bilateral, and peripheral distributions of GGO are the main characteristics related to COVID-19 pneumonia. Chest HRCT can be considered a standard method for timely and efficient assessment of disease progression and management severity. With its fusion with AI tools, chest HRCT can be used as a one-stop platform for radiological investigation and automated diagnosis system.PMID:36275840 | PMC:PMC9576693 | DOI:10.1016/j.bspc.2022.104297
Source: Cancer Control - October 24, 2022 Category: Cancer & Oncology Authors: Upasana Bhattacharjya Kandarpa Kumar Sarma Jyoti Prakash Medhi Binoy Kumar Choudhury Geetanjali Barman Source Type: research